Search Results - "Goyer, Robert A."
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Mineral arsenicals in traditional medicines: orpiment, realgar, and arsenolite
Published in The Journal of pharmacology and experimental therapeutics (01-08-2008)“…Mineral arsenicals have long been used in traditional medicines for various diseases, yet arsenic can be highly toxic and carcinogenic. Arsenic in traditional…”
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Mercury in traditional medicines: is cinnabar toxicologically similar to common mercurials?
Published in Experimental biology and medicine (Maywood, N.J.) (01-07-2008)“…Mercury is a major toxic metal ranked top in the Toxic Substances List. Cinnabar, which contains mercury sulfide, has been used in Chinese traditional…”
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Toxic and essential metal interactions
Published in Annual review of nutrition (01-01-1997)“…Cadmium, lead, mercury, and aluminum are toxic metals that may interact metabolically with nutritionally essential metals. Iron deficiency increases absorption…”
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Cadmium and cancer of prostate and testis
Published in Biometals (01-10-2004)“…Cancer of the prostate is an important and potentially fatal disease in humans but the etiology is yet undefined. Cadmium and cadmium compounds are known to be…”
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Results of Lead Research: Prenatal Exposure and Neurological Consequences
Published in Environmental health perspectives (01-10-1996)“…The history of advances in the understanding of the toxic effects of lead over the past 20 years is an outstanding example of how knowledge learned from…”
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Potential Role of α-Synuclein and Metallothionein in Lead-Induced Inclusion Body Formation
Published in Toxicological sciences (01-09-2009)“…Lead (Pb) produces aggresome-like inclusion bodies (IBs) in target cells as a toxic response. Our prior work shows metallothionein (MT) is required for this…”
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Lead Toxicity: Current Concerns
Published in Environmental health perspectives (01-04-1993)“…Over the 20-year period since the first issue of Environmental Health Perspectives was published, there has been considerable progress in the understanding of…”
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Metallothionein-I/II double knockout mice are hypersensitive to lead-induced kidney carcinogenesis: Role of inclusion body formation
Published in Cancer research (Chicago, Ill.) (01-11-2004)“…Lead is an environmental nephrotoxicant and probable human carcinogen. Elucidating factors predisposing populations to lead toxicity is an important public…”
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Transplacental Transport of Lead
Published in Environmental health perspectives (01-11-1990)“…Neurotoxicity is the major health effect from exposure to lead for infants and young children, and there is current concern regarding possible toxic effects of…”
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Nutrition and metal toxicity
Published in The American journal of clinical nutrition (01-03-1995)“…Lead, cadmium, and mercury are toxic metals that are not essential for nutrition. However, the toxic effects of these metals may be mediated or enhanced by…”
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The Metallothionein-Null Phenotype Is Associated with Heightened Sensitivity to Lead Toxicity and an Inability to Form Inclusion Bodies
Published in The American journal of pathology (01-03-2002)“…Susceptibility to lead toxicity in MT-null mice and cells, lacking the major forms of the metallothionein (MT) gene, was compared to wild-type (WT) mice or…”
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Lead Toxicity: From Overt to Subclinical to Subtle Health Effects
Published in Environmental health perspectives (01-06-1990)“…Although the toxicity of lead was recognized centuries ago, concern was restricted to overt symptoms: colic, encephalopathy, anemia, or renal disease. Two…”
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Metallothionein-I/II Double Knockout Mice Are Hypersensitive to Lead-Induced Kidney Carcinogenesis
Published in Cancer research (Chicago, Ill.) (01-11-2004)“…Lead is an environmental nephrotoxicant and probable human carcinogen. Elucidating factors predisposing populations to lead toxicity is an important public…”
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Non-metallothionein-bound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat
Published in Toxicology and applied pharmacology (01-11-1989)“…Male rats were injected SC with 0.6 mg Cd/kg/day for 5 days per week for 2, 4, 6, and 8 weeks. Liver and kidney were examined morphologically and analyzed for…”
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Concluding Remarks on the Toxicity of Essential Metals
Published in Scandinavian Journal of Work, Environment & Health (01-01-1993)Get full text
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Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals
Published in Toxicological sciences (01-06-2000)“…Metallothionein (MT) is a low-molecular-weight, sulfhydryl-rich, metal-binding protein that can protect against the toxicity of cadmium, mercury, and copper…”
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Cadmium-metallothionein-induced nephropathy
Published in Toxicology and applied pharmacology (01-11-1976)Get more information
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Immunohistochemical evidence of high concentrations of metallothionein in pancreatic hepatocytes induced by cadmium in rats
Published in Toxicologic pathology (01-01-1992)“…A recent study from our laboratory has shown that cadmium, a toxic heavy metal, is one of the most effective agents known for inducing hepatocytic…”
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Recognizable Patterns of Human Malformation: Genetic, Embryologic, and Clinical Aspects
Published in JAMA : the journal of the American Medical Association (28-09-1970)“…The Chromosome Disorders: An Introduction for Clinicians, by G. H. Valentine, ed 2; 172 pp, 86 illus, $8, Philadelphia: J. B. Lippincott Co., 1970.An…”
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Human Genetics
Published in JAMA : the journal of the American Medical Association (26-01-1970)“…The impact of new techniques and knowledge in genetics on medical practice continues to grow. This new edition of McKusick's well-known monograph on human…”
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