Only hydrosalpinges visible on ultrasound are associated with reduced implantation and pregnancy rates after in-vitro fertilization

A retrospective analysis of clinical and laboratory data was made of all in-vitro fertilization (IVF) patients with tubal pathology who had their first ever embryo transfer cycle between January 1st, 1992 and September 1st, 1996. The aim of the study was to determine the effect of the presence of a...

Full description

Saved in:

Bibliographic Details
Published in:	Human reproduction (Oxford) Vol. 13; no. 6; pp. 1696 - 1701
Main Authors:	de Wit, W, Gowrising, C J, Kuik, D J, Lens, J W, Schats, R
Format:	Journal Article
Language:	English
Published:	Oxford Oxford University Press 01-06-1998
Subjects:	Adult Biological and medical sciences Birth control Embryo Transfer Fallopian Tube Diseases - diagnostic imaging Fallopian Tube Diseases - physiopathology Fallopian Tube Diseases - surgery Female Fertilization in Vitro Gynecology. Andrology. Obstetrics Humans Laparoscopy Medical sciences Predictive Value of Tests Pregnancy Pregnancy Rate Sterility. Assisted procreation Ultrasonography Sonography Human Prognosis Hydrosalpinx Toxicity Assisted procreation Female sterility Female genital diseases In vitro fertilization embryo transfer Pregnancy Multiple pregnancy Ovum implantation Echography Female Diagnosis Fallopian tube pathology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A retrospective analysis of clinical and laboratory data was made of all in-vitro fertilization (IVF) patients with tubal pathology who had their first ever embryo transfer cycle between January 1st, 1992 and September 1st, 1996. The aim of the study was to determine the effect of the presence of a hydrosalpinx, whether or not visible by ultrasound, on pregnancy, multiple pregnancy and implantation rates in our patient population. The IVF success rate was also analysed by calculating cumulative ongoing pregnancy rates of the same patient group using the lifetime table approach. In the presence of an ultrasound-visible hydrosalpinx, rates of pregnancy and multiple pregnancy appeared reduced, but the differences were not significant. The rates of implantation, clinical implantation and ongoing implantation were significantly lower in the presence of an ultrasound-visible hydrosalpinx (odds ratios 0.33-0.46, C.I. 0.21-0.96). The cumulative chance of achieving an ongoing pregnancy after one or more IVF cycles was significantly reduced in the presence of an ultrasound-visible hydrosalpinx (relative hazard 0.36, C.I. 0.22-0.59). In the presence of a hydrosalpinx not visible by ultrasound the IVF outcome was not reduced. This retrospective study confirms that patients with hydrosalpinges have an impaired IVF outcome. Unique to this study and previously unobserved is the finding that there is a subgroup of patients with hydrosalpinges, those with ultrasound-visible hydrosalpinges, which is exclusively responsible for this impaired outcome.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0268-1161 1460-2350
DOI:	10.1093/humrep/13.6.1696