Search Results - "Gowrishankar, T.R."

A brief overview of electroporation pulse strength–duration space: A region where additional intracellular effects are expected by Weaver, James C., Smith, Kyle C., Esser, Axel T., Son, Reuben S., Gowrishankar, T.R.

“…Electroporation (EP) of outer cell membranes is widely used in research, biotechnology and medicine. Now intracellular effects by organelle EP are of growing…”
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Mechanisms for the Intracellular Manipulation of Organelles by Conventional Electroporation by Esser, Axel T., Smith, Kyle C., Gowrishankar, T.R., Vasilkoski, Zlatko, Weaver, James C.

“…Conventional electroporation (EP) changes both the conductance and molecular permeability of the plasma membrane (PM) of cells and is a standard method for…”
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Transport lattice approach to describing cell electroporation: use of a local asymptotic model by Stewart, D.A., Gowrishankar, T.R., Weaver, J.C.

“…Electroporation has been widely used to manipulate cells and tissues, but quantitative understanding of electrical behavior in cell membranes has not been…”
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Cylindrical cell membranes in uniform applied electric fields: validation of a transport lattice method by Stewart, D.A., Gowrishankar, T.R., Smith, K.C., Weaver, J.C.

“…The frequency and time domain transmembrane voltage responses of a cylindrical cell in an external electric field are calculated using a transport lattice,…”
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Hidden realities of electrical injuries by McCollum, Kyle, Gowrishankar, T.R., Lee, Raphael C.

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Hidden realities of electrical injuries by McCollum, Kyle, Gowrishankar, T.R., Lee, Raphael C.

“…The clinical spectrum of electrical injury ranges from the absence of any external physical signs to severe and life-threatening trauma. This article discusses…”
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Electrical behavior and pore accumulation in a multicellular model for conventional and supra-electroporation by Gowrishankar, T.R., Weaver, James C.

“…Extremely large but very short (20kV/cm, 300ns) electric field pulses were reported recently to non-thermally destroy melanoma tumors. The stated mechanism for…”
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Emergence of a large pore subpopulation during electroporating pulses by Smith, Kyle C., Son, Reuben S., Gowrishankar, T.R., Weaver, James C.

“…Electroporation increases ionic and molecular transport through cell membranes by creating transient aqueous pores. These pores cannot be directly observed…”
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The Spatially Distributed Dynamic Transmembrane Voltage of Cells and Organelles due to 10 ns Pulses: Meshed Transport Networks by Smith, K.C., Gowrishankar, T.R., Esser, A.T., Stewart, D.A., Weaver, J.C.

“…The authors describe two versions of a two-dimensional (2-D) cell model that contains three circular membranes representing the plasma membrane (PM) and single…”
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Transdermal drug delivery by localized intervention by Gowrishankar, T.R., Herndon, T.O., Weaver, J.C.

“…Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal…”
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Model of a confined spherical cell in uniform and heterogeneous applied electric fields by Gowrishankar, T.R., Stewart, Donald A., Weaver, James C.

“…Cells exposed to electric fields are often confined to a small volume within a solid tissue or within or near a device. Here we report on an approach to…”
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Three dimensional transport lattice model for describing action potentials in axons stimulated by external electrodes by Stewart, Donald A., Gowrishankar, T.R., Weaver, James C.

“…Conditions that stimulate action potentials in one or more nerves is of widespread interest. Axon and nerve models are usually based on two dimensional…”
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Skin Heating and Injury by Prolonged Millimeter-Wave Exposure: Theory Based on a Skin Model Coupled to a Whole Body Model and Local Biochemical Release From Cells at Supraphysiologic Temperatures by Stewart, D.A., Gowrishankar, T.R., Weaver, J.C.

“…Energy dissipation by millimeter-wavelength electromagnetic-radiation (MMW; f~3-300 GHz) exposure to mammalian skin occurs within the outer surface. The…”
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Electroporation of a lipid bilayer as a chemical reaction by Bier, Martin, Gowrishankar, T.R., Chen, Wei, Lee, Raphael C.

“…When a cell's transmembrane potential is increased from a physiological one to more than 370 mV, the transmembrane current increases more than hundredfold…”
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Spatially constrained skin electroporation with sodium thiosulfate and urea creates transdermal microconduits by ILIC, L, GOWRISHANKAR, T. R, VAUGHAN, T. E, HERNDON, T. O, WEAVER, J. C

“…Controlled transport of molecules through the skin's main barrier, the stratum corneum (SC), is a long standing goal of transdermal drug delivery. Traditional,…”
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Microfabrication of Individual 200μm Diameter Transdermal Microconduits Using High Voltage Pulsing in Salicylic Acid and Benzoic Acid by Herndon, Terry O., Ilic, Ljubomir, Gowrishankar, T.R., Vaughan, Timothy E., Weaver, James C.

“…We describe an extension of semiconductor fabrication methods that creates individual ≈ 200;μm diameter aqueous pathways through human stratum corneum at…”
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Spatially constrained localized transport regions due to skin electroporation by Gowrishankar, T.R., Herndon, Terry O., Vaughan, Timothy E., Weaver, James C.

“…Rapid, controlled molecular transport across human skin is of great interest for transdermal drug delivery and minimally invasive chemical sensing. Short,…”
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Fingerprint identification on a massively parallel architecture by Gowrishankar, T.R.

“…A feature-based recognition scheme for fingerprint identification on a massively parallel system is presented. The algorithm provides an…”
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In silico estimates of cell electroporation by electrical incapacitation waveforms by Gowrishankar, T.R., Esser, A.T., Smith, K.C., Burns, S.K., Weaver, J.C.

“…We use a system model of a cell and approximate magnitudes of electrical incapacitation (EI) device waveforms to estimate conditions that lead to responses…”
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Electroporation of a multicellular system: asymptotic model analysis by Gowrishankar, T.R., Stewart, C., Weaver, J.C.

“…Quantitative understanding of electroporation in a multicellular system has been limited. The transient aqueous pore theory describes electroporation as the…”
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