Search Results - "Gown, Allen M."

Current issues in ER and HER2 testing by IHC in breast cancer by Gown, Allen M

“…The presence of estrogen receptors (ERs), as detected by immunohistochemistry (IHC), is a weak prognostic marker of clinical outcome in breast cancer, but a…”
Get full text

Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group by Husain, Aliya Noor, Colby, Thomas V, Ordóñez, Nelson G, Allen, Timothy Craig, Attanoos, Richard Luther, Beasley, Mary Beth, Butnor, Kelly Jo, Chirieac, Lucian R, Churg, Andrew M, Dacic, Sanja, Galateau-Sallé, Françoise, Gibbs, Allen, Gown, Allen M, Krausz, Thomas, Litzky, Leslie Anne, Marchevsky, Alberto, Nicholson, Andrew G, Roggli, Victor Louis, Sharma, Anupama K, Travis, William D, Walts, Ann E, Wick, Mark R

“…- Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. - To provide updated, practical guidelines for the pathologic diagnosis…”
Get full text

BAP1 Immunohistochemistry and p16 FISH to Separate Benign From Malignant Mesothelial Proliferations by Sheffield, Brandon S, Hwang, Harry C, Lee, Anna F, Thompson, Kim, Rodriguez, Stephanie, Tse, Christopher H, Gown, Allen M, Churg, Andrew

“…A variety of immunohistochemical (IHC) stains have been proposed to mark either benign or malignant mesothelial proliferations. Loss of the p16 tumor…”
Get full text

Utility of BAP1 Immunohistochemistry and p16 (CDKN2A) FISH in the Diagnosis of Malignant Mesothelioma in Effusion Cytology Specimens by Hwang, Harry C, Sheffield, Brandon S, Rodriguez, Stephanie, Thompson, Kim, Tse, Christopher H, Gown, Allen M, Churg, Andrew

“…The diagnosis of malignant mesothelioma in effusion cytology specimens is controversial. BAP1 immunohistochemistry and p16 fluorescence in situ hybridization…”
Get full text

BAP1 Immunohistochemistry and p16 FISH in the Diagnosis of Sarcomatous and Desmoplastic Mesotheliomas by Hwang, Harry C, Pyott, Shawna, Rodriguez, Stephanie, Cindric, Ashlie, Carr, April, Michelsen, Carmen, Thompson, Kim, Tse, Christopher H, Gown, Allen M, Churg, Andrew

“…The separation of sarcomatous and desmoplastic mesotheliomas from benign organizing pleuritis can be morphologically very difficult. Deletion of p16 (CDKN2A)…”
Get full text

Markers of metastatic carcinoma of breast origin by Gown, Allen M, Fulton, Regan S, Kandalaft, Patricia L

“…This review summarizes the three major breast‐associated markers that can be of assistance in evaluating metastatic carcinomas for which a breast primary…”
Get full text

Optimal Immunohistochemical Markers For Distinguishing Lung Adenocarcinomas From Squamous Cell Carcinomas in Small Tumor Samples by TERRY, Jefferson, LEUNG, Samuel, LASKIN, Janessa, LESLIE, Kevin O, GOWN, Allen M, IONESCU, Diana N

“…The histologic subtype of non-small cell lung carcinoma is important in selecting appropriate chemotherapy for patients with advanced disease. As many of these…”
Get full text

An international study to increase concordance in Ki67 scoring by Polley, Mei-Yin C, Leung, Samuel C Y, Gao, Dongxia, Mastropasqua, Mauro G, Zabaglo, Lila A, Bartlett, John M S, McShane, Lisa M, Enos, Rebecca A, Badve, Sunil S, Bane, Anita L, Borgquist, Signe, Fineberg, Susan, Lin, Ming-Gang, Gown, Allen M, Grabau, Dorthe, Gutierrez, Carolina, Hugh, Judith C, Moriya, Takuya, Ohi, Yasuyo, Osborne, C Kent, Penault-Llorca, Frédérique M, Piper, Tammy, Porter, Peggy L, Sakatani, Takashi, Salgado, Roberto, Starczynski, Jane, Lænkholm, Anne-Vibeke, Viale, Giuseppe, Dowsett, Mitch, Hayes, Daniel F, Nielsen, Torsten O

“…Although an important biomarker in breast cancer, Ki67 lacks scoring standardization, which has limited its clinical use. Our previous study found variability…”
Get full text

Human Epidermal Growth Factor Receptor 2 Overexpression As a Prognostic Factor in a Large Tissue Microarray Series of Node-Negative Breast Cancers by CHIA, Stephen, NORRIS, Brian, SPEERS, Caroline, CHEANG, Maggie, GILKS, Blake, GOWN, Allen M, HUNTSMAN, David, OLIVOTTO, Ivo A, NIELSEN, Torsten O, GELMON, Karen

“…Human epidermal growth factor receptor 2 gene (HER2) is associated with a poorer outcome in node-positive breast cancer, but the results are conflicting in…”
Get full text

Thyroid Transcription Factor-1 Expression in Breast Carcinomas by ROBENS, Judith, GOLDSTEIN, Lynn, GOWN, Allen M, SCHNITT, Stuart J

“…Immunostaining for thyroid transcription factor-1 (TTF-1) is frequently used to help assess the site of origin of metastatic carcinomas. TTF-1 expression is…”
Get full text

IMP3 and GLUT-1 immunohistochemistry for distinguishing benign from malignant mesothelial proliferations by Lee, Anna F, Gown, Allen M, Churg, Andrew

“…Distinguishing malignant mesotheliomas from benign mesothelial proliferations on hematoxylin and eosin-stained sections can be extremely challenging. Various…”
Get full text

Determining True HER2 Gene Status in Breast Cancers With Polysomy by Using Alternative Chromosome 17 Reference Genes: Implications for Anti-HER2 Targeted Therapy by HING TSE, Chun, HWANG, Harry C, GOLDSTEIN, Lynn C, KANDALAFT, Patricia L, WILEY, Jesse C, KUSSICK, Steven J, GOWN, Allen M

“…The ratio of human epidermal growth factor receptor 2 (HER2) to CEP17 by fluorescent in situ hybridization (FISH) with the centromeric probe CEP17 is used to…”
Get full text

Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma by NIELSEN, Torsten O, HSU, Forrest D, AKSLEN, Lars A, RAGAZ, Joseph, GOWN, Allen M, GILKS, C. Blake, VAN DE RIJN, Matt, PEROU, Charles M, JENSEN, Kristin, CHEANG, Maggie, KARACA, Gamze, ZHIYUAN HU, HERNANDEZ-BOUSSARD, Tina, LIVASY, Chad, COWAN, Dave, DRESSLER, Lynn

“…Purpose: Expression profiling studies classified breast carcinomas into estrogen receptor (ER)+/luminal, normal breast-like, HER2 overexpressing, and…”
Get full text

Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group by Husain, Aliya N, Colby, Thomas V, Ordóñez, Nelson G, Krausz, Thomas, Borczuk, Alain, Cagle, Philip T, Chirieac, Lucian R, Churg, Andrew, Galateau-Salle, Francoise, Gibbs, Allen R, Gown, Allen M, Hammar, Samuel P, Litzky, Leslie A, Roggli, Victor L, Travis, William D, Wick, Mark R

“…Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. To develop practical guidelines for the pathologic diagnosis of MM. A…”
Get full text

Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfall by Bahrami, Armita, Gown, Allen M, Baird, Geoffrey S, Hicks, M John, Folpe, Andrew L

“…Alveolar rhabdomyosarcoma may be extremely difficult to distinguish from other primitive round cell neoplasms without ancillary immunohistochemistry and/or…”
Get full text

Human Epidermal Growth Factor Receptor 2 Assessment in a Case-Control Study: Comparison of Fluorescence In Situ Hybridization and Quantitative Reverse Transcription Polymerase Chain Reaction Performed by Central Laboratories by BAEHNER, Frederick L, ACHACOSO, Ninah, MADDALA, Tara, SHAK, Steve, QUESENBERRY, Charles P, GOLDSTEIN, Lynn C, GOWN, Allen M, HABEL, Laurel A

“…The optimal method to assess human epidermal growth factor receptor 2 (HER2) status remains highly controversial. Before reporting patient HER2 results,…”
Get full text

Diagnostic Utility of Galectin-3 in Thyroid Cancer by Chiu, Connie G, Strugnell, Scott S, Griffith, Obi L, Jones, Steven J.M, Gown, Allen M, Walker, Blair, Nabi, Ivan R, Wiseman, Sam M

“…Galectin-3 (Gal-3), which has received significant recent attention for its utility as a diagnostic marker for thyroid cancer, represents the most well-studied…”
Get full text

Cytokeratins 7 and 20 in primary and secondary mucinous tumors of the ovary : Analysis of coordinate immunohistochemical expression profiles and staining distribution in 179 cases by VANG, Russell, GOWN, Allen M, BARRY, Todd S, WHEELER, Darren T, YEMELYANOVA, Anna, SEIDMAN, Jeffrey D, RONNETT, Brigitte M

“…Coordinate expression profiles for cytokeratins 7 and 20 (CK7 and CK20) are useful for distinguishing certain types of adenocarcinomas but use for distinction…”
Get full text

Evaluation of Human Epidermal Growth Factor Receptor 2 (HER2) Gene Status in Human Breast Cancer Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Specimens by Fluorescence In Situ Hybridization (FISH) by Hwang, Harry C, Gown, Allen M

“…Current standard of care requires that HER2 gene testing be performed on all newly diagnosed invasive breast cancers in order to determine eligibility for…”
Get more information

Improved Detection of Apoptotic Cells in Archival Paraffin Sections: Immunohistochemistry Using Antibodies to Cleaved Caspase 3 by Gown, Allen M, Willingham, Mark C

“…Apoptosis has gained central importance in the study of many biological processes, including neoplasia, neurodegenerative diseases, and development. One of the…”
Get full text