Search Results - "Gowland, P."

T2‐weighted placental MRI: basic research tool or emerging clinical test for placental dysfunction? by Sørensen, A., Hutter, J., Seed, M., Grant, P. E., Gowland, P.

Get full text

Maturation of the Human Cerebral Cortex During Adolescence: Myelin or Dendritic Arbor? by Patel, Y, Shin, J, Gowland, P A, Pausova, Z, Paus, T

“…Previous in vivo studies revealed robust age-related variations in structural properties of the human cerebral cortex during adolescence. Neurobiology…”
Get full text

Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the 5‐HT3 receptor antagonist, ondansetron by Gunn, D., Yeldho, C., Hoad, C., Menys, A., Gowland, P., Marciani, L., Spiller, R.

“…Background Lactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of…”
Get full text

Mechanisms underlying the laxative effect of lactulose: A randomized placebo-controlled trial showing increased small bowel water and motility unaltered by the 5-HT 3 receptor antagonist, ondansetron by Gunn, D, Yeldho, C, Hoad, C, Menys, A, Gowland, P, Marciani, L, Spiller, R

“…Lactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to…”
Get full text

Association of placental perfusion, as assessed by magnetic resonance imaging and uterine artery Doppler ultrasound, and its relationship to pregnancy outcome by Derwig, I, Lythgoe, D.J, Barker, G.J, Poon, L, Gowland, P, Yeung, R, Zelaya, F, Nicolaides, K

“…Abstract Purpose To investigate (a) if placental perfusion in the second trimester of pregnancy, measured by two non-invasive magnetic resonance imaging (MRI)…”
Get full text

Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights by Marciani, L, Pritchard, S E, Hellier-Woods, C, Costigan, C, Hoad, C L, Gowland, P A, Spiller, R C

“…Background/Objectives: Postprandial bloating is a common symptom in patients with functional gastrointestinal (GI) diseases. Whole meal bread (WMB) often…”
Get full text

Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea‐predominant irritable bowel syndrome measured using serial MRI by Pritchard, S. E., Marciani, L., Garsed, K. C., Hoad, C. L., Thongborisute, W., Roberts, E., Gowland, P. A., Spiller, R. C.

“…Background Previous assessments of colon morphology have relied on tests which were either invasive or used ionizing radiation. We aimed to measure regional…”
Get full text

4-dimensional local radial basis function interpolation of large, uniformly spaced datasets by Thewlis, J., Stevens, D., Power, H., Giddings, D., Gowland, P., Vloeberghs, M.

“…•sparse data from MRI velocimetry can be interpolated using radial basis functions.•the interpolation is in time as well as 3D space.•sparse data in the…”
Get full text

Demonstration of differences in colonic volumes, transit, chyme consistency, and response to psyllium between healthy and constipated subjects using magnetic resonance imaging by Major, G., Murray, K., Singh, G., Nowak, A., Hoad, C. L., Marciani, L., Silos‐Santiago, A., Kurtz, C. B., Johnston, J. M., Gowland, P., Spiller, R.

“…Background In functional gastrointestinal disorders a lack of objective biomarkers limits evaluation of underlying mechanisms. We aimed to demonstrate the…”
Get full text

Magnetization transfer phenomenon in the human brain at 7 T by Mougin, O.E., Coxon, R.C., Pitiot, A., Gowland, P.A.

“…Magnetization transfer is an important source of contrast in magnetic resonance imaging which is sensitive to the concentration of macromolecules and other…”
Get full text

Effects of various food ingredients on gall bladder emptying by Marciani, L, Cox, E F, Hoad, C L, Totman, J J, Costigan, C, Singh, G, Shepherd, V, Chalkley, L, Robinson, M, Ison, R, Gowland, P A, Spiller, R C

“…Background/objectives: The emptying of the gall bladder in response to feeding is pivotal for the digestion of fat, but the role of various food ingredients in…”
Get full text

13C-magnetic resonance spectroscopy; a viable technique to study overnight liver glycogen depletion and response to feeding in 8–12-year-old children by Simpson, E.J., Horstman, A.M.H., Bawden, S.J., Spicer, A., Darwish, N., Gowland, P., Breuillé, D., Macdonald, I.A.

“…There is a paucity of normative data for liver glycogen concentration ([LGly]) in children to allow comparison with patient cohorts, and time-course assessment…”
Get full text

Measurement of gastric meal and secretion volumes using magnetic resonance imaging by Hoad, C L, Parker, H, Hudders, N, Costigan, C, Cox, E F, Perkins, A C, Blackshaw, P E, Marciani, L, Spiller, R C, Fox, M R, Gowland, P A

“…MRI can assess multiple gastric functions without ionizing radiation. However, time consuming image acquisition and analysis of gastric volume data, plus…”
Get more information

Assessment of motion of colonic contents in the human colon using MRI tagging by Pritchard, S. E., Paul, J., Major, G., Marciani, L., Gowland, P. A., Spiller, R. C., Hoad, C. L.

“…Background We have previously reported a non‐invasive, semi‐automated technique to assess motility of the wall of the ascending colon (AC) using Magnetic…”
Get full text

Genomic architecture of human neuroanatomical diversity by Toro, R, Poline, J-B, Huguet, G, Loth, E, Frouin, V, Banaschewski, T, Barker, G J, Bokde, A, Büchel, C, Carvalho, F M, Conrod, P, Fauth-Bühler, M, Flor, H, Gallinat, J, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Lawrence, C, Lemaître, H, Mann, K, Nees, F, Paus, T, Pausova, Z, Rietschel, M, Robbins, T, Smolka, M N, Ströhle, A, Schumann, G, Bourgeron, T

“…Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect…”
Get full text

Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation by Lam, C., Chaddock, G., Marciani, L., Costigan, C., Paul, J., Cox, E., Hoad, C., Menys, A., Pritchard, S., Garsed, K., Taylor, S., Atkinson, D., Gowland, P., Spiller, R.

“…Background Functional constipation (FC) and irritable bowel syndrome with constipation (IBS‐C) share many symptoms but underlying mechanisms may be different…”
Get full text

Dual registration of abdominal motion for motility assessment in free-breathing data sets acquired using dynamic MRI by Menys, A, Hamy, V, Makanyanga, J, Hoad, C, Gowland, P, Odille, F, Taylor, S A, Atkinson, D

“…At present, registration-based quantification of bowel motility from dynamic MRI is limited to breath-hold studies. Here we validate a dual-registration…”
Get more information

Investigating the effects of an oral fructose challenge on hepatic ATP reserves in healthy volunteers: A (31)P MRS study by Bawden, S J, Stephenson, M C, Ciampi, E, Hunter, K, Marciani, L, Macdonald, I A, Aithal, G P, Morris, P G, Gowland, P A

“…Impaired homeostasis of hepatic ATP has been associated with NAFLD. An intravenous fructose infusion has been shown to be an effective challenge to monitor the…”
Get full text

Association of placental T2 relaxation times and uterine artery Doppler ultrasound measures of placental blood flow by Derwig, I, Barker, G.J, Poon, L, Zelaya, F, Gowland, P, Lythgoe, D.J, Nicolaides, K

“…Abstract Purpose To investigate whether, in the second trimester of pregnancy, placental T2 relaxation time (determined using magnetic resonance imaging (MRI))…”
Get full text

MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans by Khalaf, A., Hoad, C. L., Menys, A., Nowak, A., Taylor, S. A., Paparo, S., Lingaya, M., Falcone, Y., Singh, G., Spiller, R. C., Gowland, P. A., Marciani, L., Moran, G. W.

“…Background Feeding triggers inter‐related gastrointestinal (GI) motor, peptide and appetite responses. These are rarely studied together due to methodological…”
Get full text