Search Results - "Gowing, Emma K"

Combined Ampakine and BDNF Treatments Enhance Poststroke Functional Recovery in Aged Mice via AKT-CREB Signaling by Clarkson, Andrew N, Parker, Kim, Nilsson, Michael, Walker, F Rohan, Gowing, Emma K

“…Cerebral ischemia results in damage to neuronal circuits and lasting impairment in function. We have previously reported that stimulation of…”
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A Novel Rat Model of ADHD-like Hyperactivity/Impulsivity after Delayed Reward Has Selective Loss of Dopaminergic Neurons in the Right Ventral Tegmental Area by Kohe, Sarah E, Gowing, Emma K, Seo, Steve, Oorschot, Dorothy E

“…In attention deficit hyperactivity disorder (ADHD), hyperactivity and impulsivity occur in response to reward. Herein we report a novel animal model in which…”
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Vascular perfusion differs in two distinct PDGFRβ‐positive zones within the ischemic core of male mice 2 weeks following photothrombotic stroke by Morris, Gary P., Gowing, Emma K., Courtney, Jo‐Maree, Coombe, Hannah E., King, Natalie E., Rewell, Sarah S. J., Howells, David W., Clarkson, Andrew N., Sutherland, Brad A.

“…Stroke therapy has largely focused on preventing damage and encouraging repair outside the ischemic core, as the core is considered irreparable. Recently,…”
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The CaMKIIα hub ligand Ph-HTBA promotes neuroprotection after focal ischemic stroke by a distinct molecular interaction by Griem-Krey, Nane, Gauger, Stine J., Gowing, Emma K., Thiesen, Louise, Frølund, Bente, Clarkson, Andrew N., Wellendorph, Petrine

“…Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a potential target for acute neuroprotection due to its key role in physiological and…”
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The Delta-Subunit Selective GABAA Receptor Modulator, DS2, Improves Stroke Recovery via an Anti-inflammatory Mechanism by Neumann, Silke, Boothman-Burrell, Lily, Gowing, Emma K., Jacobsen, Thomas A., Ahring, Philip K., Young, Sarah L., Sandager-Nielsen, Karin, Clarkson, Andrew N.

“…Inflammatory processes are known to contribute to tissue damage in the central nervous system (CNS) across a broad range of neurological conditions, including…”
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Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia by Lie, Maria EK, Gowing, Emma K, Clausen, Rasmus P, Wellendorph, Petrine, Clarkson, Andrew N

“…Brain ischemia triggers excitotoxicity and cell death, yet no neuroprotective drugs have made it to the clinic. While enhancing GABAergic signaling to…”
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Stroke Induces a BDNF-Dependent Improvement in Cognitive Flexibility in Aged Mice by Gowing, Emma K., Barwick, Deanna, Zhou, Lisa Y. Y., Houlton, Josh, Clarkson, Andrew N.

“…Stroke remains a leading cause of disability worldwide. Recently, we have established an animal model of stroke that results in delayed impairment in spatial…”
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Perlecan Domain-V Enhances Neurogenic Brain Repair After Stroke in Mice by Trout, Amanda L., Kahle, Michael P., Roberts, Jill M., Marcelo, Aileen, de Hoog, Leon, Boychuk, Jeffery A., Grupke, Stephen L., Berretta, Antonio, Gowing, Emma K., Boychuk, Carie R., Gorman, Amanda A., Edwards, Danielle N., Rutkai, Ibolya, Biose, Ifechukwude J., Ishibashi-Ueda, Hatsue, Ihara, Masafumi, Smith, Bret N., Clarkson, Andrew N., Bix, Gregory J.

“…The extracellular matrix fragment perlecan domain V is neuroprotective and functionally restorative following experimental stroke. As neurogenesis is an…”
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Sonic hedgehog stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosis by Berretta, Antonio, Gowing, Emma K., Jasoni, Christine L., Clarkson, Andrew N.

“…Although recovery following a stroke is limited, undamaged neurons under the right conditions can establish new connections and take on-board lost functions…”
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GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice by Lie, Maria EK, Gowing, Emma K, Johansen, Nina B, Dalby, Nils Ole, Thiesen, Louise, Wellendorph, Petrine, Clarkson, Andrew N

“…Ischemic stroke triggers an elevation in tonic GABA inhibition that impairs the ability of the brain to form new structural and functional cortical circuits…”
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Effects of nidopallium caudolaterale inactivation on serial-order behavior in pigeons ( Columba livia) by Johnston, Melissa, Clarkson, Andrew N, Gowing, Emma K, Scarf, Damian, Colombo, Michael

“…Serial-order behavior is the ability to complete a sequence of responses in a predetermined order to achieve a reward. In birds, serial-order behavior is…”
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The Gliopeptide ODN, a Ligand for the Benzodiazepine Site of GABAA Receptors, Boosts Functional Recovery after Stroke by Lamtahri, Rhita, Hazime, Mahmoud, Gowing, Emma K, Nagaraja, Raghavendra Y, Maucotel, Julie, Alasoadura, Michael, Quilichini, Pascale P, Lehongre, Katia, Lefranc, Benjamin, Gach-Janczak, Katarzyna, Marcher, Ann-Britt, Mandrup, Susanne, Vaudry, David, Clarkson, Andrew N, Leprince, Jérôme, Chuquet, Julien

“…Following stroke, the survival of neurons and their ability to reestablish connections is critical to functional recovery. This is strongly influenced by the…”
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Age-dependent Disturbances of Neuronal and Glial Protein Expression Profiles in Areas of Secondary Neurodegeneration Post-stroke by Kluge, Murielle G., Jones, Kimberley, Kooi Ong, Lin, Gowing, Emma K., Nilsson, Michael, Clarkson, Andrew N., Walker, Frederick R.

“…•Age exacerbates neurodegeneration after stroke in terms of synaptic protein expression.•Age increases the aggregation and alters the accumulation profile of…”
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GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain by Leurs, Ulrike, Klein, Anders B., McSpadden, Ethan D., Griem-Krey, Nane, Solbak, Sara M. Ø., Houlton, Josh, Villumsen, Inge S., Vogensen, Stine B., Hamborg, Louise, Gauger, Stine J., Palmelund, Line B., Larsen, Anne Sofie G., Shehata, Mohamed A., Kelstrup, Christian D., Olsen, Jesper V., Bach, Anders, Burnie, Robert O., Kerr, D. Steven, Gowing, Emma K., Teurlings, Selina M. W., Chi, Chris C., Gee, Christine L., Frølund, Bente, Kornum, Birgitte R., van Woerden, Geeske M., Clausen, Rasmus P., Kuriyan, John, Clarkson, Andrew N., Wellendorph, Petrine

“…Ca2+/calmodulin-dependent protein kinase II alpha subunit (CaMKIIα) is a key neuronal signaling protein and an emerging drug target. The central hub domain…”
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Neuroprotective activity of new Δ3‐N‐acylethanolamines in a focal ischemia stroke model by Shirazi, Rahau S., Vyssotski, Mikhail, Lagutin, Kirill, Thompson, Dion, MacDonald, Christa, Luscombe, Vincent, Glass, Michelle, Parker, Kim, Gowing, Emma K., Williams, D. Bradley G., Clarkson, Andrew N.

“…N‐acylethanolamines (NAE, also called ethanolamides) are significant lipid signaling molecules with anti‐inflammatory, pain‐relieving, cell‐protective, and…”
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Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke by Evans, Megan A, Lim, Rebecca, Kim, Hyun Ah, Chu, Hannah X, Gardiner-Mann, Chantelle V, Taylor, Kimberly W.E, Chan, Christopher T, Brait, Vanessa H, Lee, Seyoung, Dinh, Quynh Nhu, Vinh, Antony, Phan, Thanh G, Srikanth, Velandai K, Ma, Henry, Arumugam, Thiruma V, Fann, David Y, Poh, Luting, Hunt, Cameron P.J, Pouton, Colin W, Haynes, John M, Selemidis, Stavros, Kwan, William, Teo, Leon, Bourne, James A, Neumann, Silke, Young, Sarah, Gowing, Emma K, Drummond, Grant R, Clarkson, Andrew N, Wallace, Euan M, Sobey, Christopher G, Broughton, Brad R.S

“…BACKGROUND AND PURPOSE—Human amnion epithelial cells (hAECs) are nonimmunogenic, nontumorigenic, anti-inflammatory cells normally discarded with placental…”
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The Gliopeptide ODN, a Ligand for the Benzodiazepine Site of GABA A Receptors, Boosts Functional Recovery after Stroke by Lamtahri, Rhita, Hazime, Mahmoud, Gowing, Emma K, Nagaraja, Raghavendra Y, Maucotel, Julie, Alasoadura, Michael, Quilichini, Pascale P, Lehongre, Katia, Lefranc, Benjamin, Gach-Janczak, Katarzyna, Marcher, Ann-Britt, Mandrup, Susanne, Vaudry, David, Clarkson, Andrew N, Leprince, Jérôme, Chuquet, Julien

“…Following stroke, the survival of neurons and their ability to reestablish connections is critical to functional recovery. This is strongly influenced by the…”
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The flavonoid, 2′-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia by Clarkson, Andrew N, Boothman-Burrell, Lily, Dósa, Zita, Nagaraja, Raghavendra Y, Jin, Liang, Parker, Kim, van Nieuwenhuijzen, Petra S, Neumann, Silke, Gowing, Emma K, Gavande, Navnath, Ahring, Philip K, Holm, Mai M, Hanrahan, Jane R, Nicolazzo, Joseph A, Jensen, Kimmo, Chebib, Mary

“…Tonic inhibitory currents, mediated by extrasynaptic GABAA receptors, are elevated at a delay following stroke. Flavonoids minimise the extent of cellular…”
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Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion by Allan, Philip D, Tzeng, Yu-Chieh, Gowing, Emma K, Clarkson, Andrew N, Fan, Jui-Lin

“…It is known that high blood pressure variability (BPV) in acute ischemic stroke is associated with adverse outcomes, yet there are no therapeutic treatments to…”
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Altered Hippocampal–Prefrontal Dynamics Following Medial Prefrontal Stroke in Mouse by Hillman, Kristin L., Wall, Hannah J., Matthews, Luke O., Gowing, Emma K., Clarkson, Andrew N.

“…Frontal infarcts can produce cognitive impairments that affect an individual’s ability to function in everyday life. However, the precise types of deficits,…”
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