Search Results - "Gowans, Lord J. J."

Rare variants analyses suggest novel cleft genes in the African population by Alade, Azeez, Mossey, Peter, Awotoye, Waheed, Busch, Tamara, Oladayo, Abimbola M., Aladenika, Emmanuel, Olujitan, Mojisola, Wentworth, Emma, Anand, Deepti, Naicker, Thirona, Gowans, Lord J. J., Eshete, Mekonen A., Adeyemo, Wasiu L., Zeng, Erliang, Van Otterloo, Eric, O’Rorke, Michael, Adeyemo, Adebowale, Murray, Jeffrey C., Cotney, Justin, Lachke, Salil A., Romitti, Paul, Butali, Azeez

“…Non-syndromic orofacial clefts (NSOFCs) are common birth defects with a complex etiology. While over 60 common risk loci have been identified, they explain…”
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Perceptions and beliefs of community gatekeepers about genomic risk information in African cleft research by Oladayo, Abimbola M, Odukoya, Oluwakemi, Sule, Veronica, Molobe, Ikenna, Busch, Tamara, Akodu, Babatunde, Adeyemo, Wasiu L, Gowans, Lord J J, Eshete, Mekonen, Alade, Azeez, Awotoye, Waheed, Adeyemo, Adebowale A, Mossey, Peter A, Prince, Anya E R, Murray, Jeffrey C, Butali, Azeez

“…A fundamental ethical issue in African genomics research is how socio-cultural factors impact perspectives, acceptance, and utility of genomic information,…”
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Genome-wide study of gene-by-sex interactions identifies risks for cleft palate by Robinson, Kelsey, Parrish, Randy, Adeyemo, Wasiu Lanre, Beaty, Terri H., Butali, Azeez, Buxó, Carmen J., Gowans, Lord J. J., Hecht, Jacqueline T., Moreno Uribe, Lina, Murray, Jeffrey C., Shaw, Gary M., Weinberg, Seth M., Brand, Harrison, Marazita, Mary L., Cutler, David J., Epstein, Michael P., Yang, Jingjing, Leslie, Elizabeth J.

“…Structural birth defects affect 3–4% of all live births and, depending on the type, tend to manifest in a sex-biased manner. Orofacial clefts (OFCs) are the…”
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Novel GRHL3 Variants in a South African Cohort With Cleft Lip and Palate by Naicker, Thirona, Adeleke, Chinyere C., Alade, Azeez, Mossey, Peter A., Awotoye, Waheed A., Busch, Tamara D., Li, Mary, Olotu, Joy, Gowans, Lord J. J., Aldous, Colleen, Butali, Azeez

“…Objective The etiology of cleft palate (CP) is poorly understood compared with that of cleft lip with or without palate (CL ± P). Recently, variants in…”
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Whole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate by Awotoye, Waheed, Mossey, Peter A., Hetmanski, Jacqueline B., Gowans, Lord J. J., Eshete, Mekonen A., Adeyemo, Wasiu L., Alade, Azeez, Zeng, Erliang, Adamson, Olawale, Naicker, Thirona, Anand, Deepti, Adeleke, Chinyere, Busch, Tamara, Li, Mary, Petrin, Aline, Aregbesola, Babatunde S., Braimah, Ramat O., Oginni, Fadekemi O., Oladele, Ayodeji O., Oladayo, Abimbola, Kayali, Sami, Olotu, Joy, Hassan, Mohaned, Pape, John, Donkor, Peter, Arthur, Fareed K. N., Obiri-Yeboah, Solomon, Sabbah, Daniel K., Agbenorku, Pius, Plange-Rhule, Gyikua, Oti, Alexander Acheampong, Gogal, Rose A., Beaty, Terri H., Taub, Margaret, Marazita, Mary L., Schnieders, Michael J., Lachke, Salil A., Adeyemo, Adebowale A., Murray, Jeffrey C., Butali, Azeez

“…The majority (85%) of nonsyndromic cleft lip with or without cleft palate (nsCL/P) cases occur sporadically, suggesting a role for de novo mutations (DNMs) in…”
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Investigating the relationship between cancer and orofacial clefts using GWAS significant loci for cancers: A case-control and case-triad study by Fashina, Azeez, Busch, Tamara, Young, Mary, Adamson, Olawale, Awotoye, Waheed, Alade, Azeez, Adeleke, Chinyere, Hassan, Mohaned, Oladayo, Abimbola M, Gowans, Lord J J, Eshete, Mekonen, Naicker, Thirona, Olotu, Joy, Adeyemo, Wasiu L, Butali, Azeez

“…Several population-based case-control studies have reported concurrent presentation of cancer and congenital malformations. Many associations have been made…”
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Co‐occurrence of orofacial clefts and clubfoot phenotypes in a sub‐Saharan African cohort: Whole‐exome sequencing implicates multiple syndromes and genes by Gowans, Lord J. J., Al Dhaheri, Noura, Li, Mary, Busch, Tamara, Obiri‐Yeboah, Solomon, Oti, Alexander A., Sabbah, Daniel K., Arthur, Fareed K. N., Awotoye, Waheed O., Alade, Azeez A., Twumasi, Peter, Agbenorku, Pius, Plange‐Rhule, Gyikua, Naicker, Thirona, Donkor, Peter, Murray, Jeffrey C., Sobreira, Nara L. M., Butali, Azeez

“…Background Orofacial clefts (OFCs) are congenital malformations of the face and palate, with an incidence of 1 per 700 live births. Clubfoot or congenital…”
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Genomic analyses in African populations identify novel risk loci for cleft palate by Butali, Azeez, Mossey, Peter A, Adeyemo, Wasiu L, Eshete, Mekonen A, Gowans, Lord J J, Busch, Tamara D, Jain, Deepti, Yu, Wenjie, Huan, Liu, Laurie, Cecelia A, Laurie, Cathy C, Nelson, Sarah, Li, Mary, Sanchez-Lara, Pedro A, Magee, William P, Magee, Kathleen S, Auslander, Allyn, Brindopke, Frederick, Kay, Denise M, Caggana, Michele, Romitti, Paul A, Mills, James L, Audu, Rosemary, Onwuamah, Chika, Oseni, Ganiyu O, Owais, Arwa, James, Olutayo, Olaitan, Peter B, Aregbesola, Babatunde S, Braimah, Ramat O, Oginni, Fadekemi O, Oladele, Ayodeji O, Bello, Saidu A, Rhodes, Jennifer, Shiang, Rita, Donkor, Peter, Obiri-Yeboah, Solomon, Arthur, Fareed Kow Nanse, Twumasi, Peter, Agbenorku, Pius, Plange-Rhule, Gyikua, Oti, Alexander Acheampong, Ogunlewe, Olugbenga M, Oladega, Afisu A, Adekunle, Adegbayi A, Erinoso, Akinwunmi O, Adamson, Olatunbosun O, Elufowoju, Abosede A, Ayelomi, Oluwanifemi I, Hailu, Taiye, Hailu, Abiye, Demissie, Yohannes, Derebew, Miliard, Eliason, Steve, Romero-Bustillous, Miguel, Lo, Cynthia, Park, James, Desai, Shaan, Mohammed, Muiawa, Abate, Firke, Abdur-Rahman, Lukman O, Anand, Deepti, Saadi, Irfaan, Oladugba, Abimibola V, Lachke, Salil A, Amendt, Brad A, Rotimi, Charles N, Marazita, Mary L, Cornell, Robert A, Murray, Jeffrey C, Adeyemo, Adebowale A

“…Abstract Orofacial clefts are common developmental disorders that pose significant clinical, economical and psychological problems. We conducted genome-wide…”
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Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation by Sweat, Yan Yan, Sweat, Mason, Mansaray, Maurisa, Cao, Huojun, Eliason, Steven, Adeyemo, Waisu L., Gowans, Lord J.J., Eshete, Mekonen A., Anand, Deepti, Chalkley, Camille, Saadi, Irfan, Lachke, Salil A., Butali, Azeez, Amendt, Brad A.

“…In this study, we investigated the role of the transcription factor Six2 in palate development. Six2 was selected using the SysFACE tool to predict genes from…”
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Shared genetic risk between major orofacial cleft phenotypes in an African population by Alade, Azeez, Peter, Tabitha, Busch, Tamara, Awotoye, Waheed, Anand, Deepti, Abimbola, Oladayo, Aladenika, Emmanuel, Olujitan, Mojisola, Rysavy, Oscar, Nguyen, Phuong Fawng, Naicker, Thirona, Mossey, Peter A., Gowans, Lord J. J., Eshete, Mekonen A., Adeyemo, Wasiu L., Zeng, Erliang, Van Otterloo, Eric, O'Rorke, Michael, Adeyemo, Adebowale, Murray, Jeffrey C., Lachke, Salil A., Romitti, Paul A., Butali, Azeez

“…Nonsyndromic orofacial clefts (NSOFCs) represent a large proportion (70%–80%) of all OFCs. They can be broadly categorized into nonsyndromic cleft lip with or…”
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Damaging Mutations in AFDN Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate by Awotoye, Waheed, Mossey, Peter A, Hetmanski, Jacqueline B, Gowans, Lord J J, Eshete, Mekonen A, Adeyemo, Wasiu L, Alade, Azeez, Zeng, Erliang, Adamson, Olawale, James, Olutayo, Fashina, Azeez, Ogunlewe, Modupe O, Naicker, Thirona, Adeleke, Chinyere, Busch, Tamara, Li, Mary, Petrin, Aline, Oladayo, Abimbola, Kayali, Sami, Olotu, Joy, Sule, Veronica, Hassan, Mohaned, Pape, John, Aladenika, Emmanuel T, Donkor, Peter, Arthur, Fareed K N, Obiri-Yeboah, Solomon, Sabbah, Daniel K, Agbenorku, Pius, Ray, Debashree, Plange-Rhule, Gyikua, Oti, Alexander Acheampong, Albokhari, Daniah, Sobreira, Nara, Dunnwald, Martine, Beaty, Terri H, Taub, Margaret, Marazita, Mary L, Adeyemo, Adebowale A, Murray, Jeffrey C, Butali, Azeez

“…Objectives Novel or rare damaging mutations have been implicated in the developmental pathogenesis of nonsyndromic cleft lip with or without cleft palate (nsCL…”
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Parents and Provider Perspectives on the Return of Genomic Findings for Cleft Families in Africa by Oladayo, Abimbola M., Prochaska, Sydney, Busch, Tamara, Adeyemo, Wasiu L., Gowans, Lord J. J., Eshete, Mekonen, Awotoye, Waheed, Sule, Veronica, Alade, Azeez, Adeyemo, Adebowale A., Mossey, Peter A., Prince, Anya, Murray, Jeffrey C., Butali, Azeez

“…Inadequate knowledge among health care providers (HCPs) and parents of affected children limits the understanding and utility of secondary genetic findings…”
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Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P) by Gowans, Lord J. J., Comnick, Carissa L., Mossey, Peter A., Eshete, Mekonen A., Adeyemo, Wasiu L., Naicker, Thirona, Awotoye, Waheed A., Petrin, Aline, Adeleke, Chinyere, Donkor, Peter, Busch, Tamara D., James, Olutayo, Ogunlewe, Mobolanle O., Li, Mary, Olotu, Joy, Hassan, Mohaned, Adeniyan, Oluwole A., Obiri-Yeboah, Solomon, Arthur, Fareed K. N., Agbenorku, Pius, Oti, Alexander A., Olatosi, Olubukola, Adamson, Olawale O., Fashina, Azeez A., Zeng, Erliang, Marazita, Mary L., Adeyemo, Adebowale A., Murray, Jeffrey C., Butali, Azeez

“…Objective Nonsyndromic cleft lip and/or cleft palate (NSCL/P) have multifactorial etiology where genetic factors, gene–environment interactions, stochastic…”
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Exome sequencing provides additional evidence for the involvement of ARHGAP29 in Mendelian orofacial clefting and extends the phenotypic spectrum to isolated cleft palate by Liu, Huan, Busch, Tamara, Eliason, Steven, Anand, Deepti, Bullard, Steven, Gowans, Lord J.J, Nidey, Nichole, Petrin, Aline, Augustine‐Akpan, Eno‐Abasi, Saadi, Irfan, Dunnwald, Martine, Lachke, Salil A., Zhu, Ying, Adeyemo, Adebowale, Amendt, Brad, Roscioli, Tony, Cornell, Robert, Murray, Jeffrey, Butali, Azeez

“…Background Recent advances in genomics methodologies, in particular the availability of next‐generation sequencing approaches have made it possible to identify…”
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Trio-based GWAS identifies novel associations and subtype-specific risk factors for cleft palate by Robinson, Kelsey, Mosley, Trenell J., Rivera-González, Kenneth S., Jabbarpour, Christopher R., Curtis, Sarah W., Adeyemo, Wasiu Lanre, Beaty, Terri H., Butali, Azeez, Buxó, Carmen J., Cutler, David J., Epstein, Michael P., Gowans, Lord J.J., Hecht, Jacqueline T., Murray, Jeffrey C., Shaw, Gary M., Uribe, Lina Moreno, Weinberg, Seth M., Brand, Harrison, Marazita, Mary L., Lipinski, Robert J., Leslie, Elizabeth J.

“…Cleft palate (CP) is one of the most common craniofacial birth defects; however, there are relatively few established genetic risk factors associated with its…”
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Non‐random distribution of deleterious mutations in the DNA and protein‐binding domains of IRF6 are associated with Van Der Woude syndrome by Alade, Azeez A., Buxo‐Martinez, Carmen J., Mossey, Peter A., Gowans, Lord J.J., Eshete, Mekonen A., Adeyemo, Wasiu L., Naicker, Thirona, Awotoye, Waheed A., Adeleke, Chinyere, Busch, Tamara, Toraño, Ada M., Bello, Carolina A., Soto, Mairim, Soto, Marilyn, Ledesma, Ricardo, Marquez, Myrellis, Cordero, Jose F., Lopez‐Del Valle, Lydia M., Salcedo, Maria I., Debs, Natalio, Li, Mary, Petrin, Aline, Olotu, Joy, Aldous, Colleen, Olutayo, James, Ogunlewe, Modupe O., Abate, Fekir, Hailu, Taye, Muhammed, Ibrahim, Gravem, Paul, Deribew, Milliard, Gesses, Mulualem, Hassan, Mohaned, Pape, John, Adeniyan, Oluwole A., Obiri‐Yeboah, Solomon, Arthur, Fareed K.N., Oti, Alexander A., Olatosi, Olubukola, Miller, Sara E., Donkor, Peter, Dunnwald, Martine M., Marazita, Mary L., Adeyemo, Adebowale A., Murray, Jeffrey C., Butali, Azeez

“…Background The development of the face occurs during the early days of intrauterine life by the formation of facial processes from the first Pharyngeal arch…”
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Identification of paternal uniparental disomy on chromosome 22 and a de novo deletion on chromosome 18 in individuals with orofacial clefts by Oseni, Ganiyu O., Jain, Deepti, Mossey, Peter A., Busch, Tamara D., Gowans, Lord J.J., Eshete, Mekonen A., Adeyemo, Wasiu L., Laurie, Cecelia A., Laurie, Cathy C., Owais, Arwa, Olaitan, Peter B., Aregbesola, Babatunde S., Oginni, Fadekemi O., Bello, Saidu A., Donkor, Peter, Audu, Rosemary, Onwuamah, Chika, Obiri‐Yeboah, Solomon, Plange‐Rhule, Gyikua, Ogunlewe, Olugbenga M., James, Olutayo, Halilu, Taiye, Abate, Firke, Abdur‐Rahman, Lukman O., Oladugba, Abimbola V., Marazita, Mary L., Murray, Jeffrey C., Adeyemo, Adebowale A., Butali, Azeez

“…Background Orofacial clefts are the most common malformations of the head and neck region. Genetic and environmental factors have been implicated in the…”
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Variant analyses of candidate genes in orofacial clefts in multi‐ethnic populations by Li, Mary, Olotu, Joy, Buxo‐Martinez, Carmen J., Mossey, Peter A., Anand, Deepti, Busch, Tamara, Alade, Azeez, Gowans, Lord J. J., Eshete, Mekonen, Adeyemo, Wasiu L., Naicker, Thirona, Awotoye, Waheed O., Gupta, Sagar, Adeleke, Chinyere, Bravo, Valeria, Huang, Siyong, Adamson, Olatunbosun O., Toraño, Ada M., Bello, Carolina A., Soto, Mairim, Soto, Marilyn, Ledesma, Ricardo, Marquez, Myrellis, Cordero, Jose F., Lopez‐Del Valle, Lydia M., Salcedo, Maria I., Debs, Natalio, Petrin, Aline, Malloy, Hannah, Elhadi, Khalid, James, Olutayo, Ogunlewe, Mobolanle O., Abate, Fekir, Hailu, Abiye, Mohammed, Ibrahim, Gravem, Paul, Deribew, Milliard, Gesses, Mulualem, Hassan, Mohaned, Pape, John, Obiri‐Yeboah, Solomon, Arthur, Fareed K. N., Oti, Alexander A., Donkor, Peter, Marazita, Mary L., Lachke, Salil A., Adeyemo, Adebowale A., Murray, Jeffrey C., Butali, Azeez

“…Objectives Cleft lip with/without cleft palate and cleft palate only is congenital birth defects where the upper lip and/or palate fail to fuse properly during…”
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Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus by Gowans, Lord J J, Cameron-Christie, Sophia, Slayton, Rebecca L, Busch, Tamara, Romero-Bustillos, Miguel, Eliason, Steven, Sweat, Mason, Sobreira, Nara, Yu, Wenjie, Kantaputra, Piranit N, Wohler, Elizabeth, Adeyemo, Wasiu Lanre, Lachke, Salil A, Anand, Deepti, Campbell, Collen, Drummond, Bernadette K, Markie, David M, van Vuuren, W Jansen, van Vuuren, L Jansen, Casamassimo, Paul S, Ettinger, Ronald, Owais, Arwa, van Staden, I, Amendt, Brad A, Adeyemo, Adebowale A, Murray, Jeffrey C, Robertson, Stephen P, Butali, Azeez

“…The etiology of dental anomalies is multifactorial; and genetic and environmental factors that affect the dental lamina have been implicated. We investigated…”
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