Search Results - "Gowans, Eric J"

A Hepatitis C Virus DNA Vaccine Encoding a Secreted, Oligomerized Form of Envelope Proteins Is Highly Immunogenic and Elicits Neutralizing Antibodies in Vaccinated Mice by Masavuli, Makutiro Ghislain, Wijesundara, Danushka K, Underwood, Alexander, Christiansen, Dale, Earnest-Silveira, Linda, Bull, Rowena, Torresi, Joseph, Gowans, Eric J, Grubor-Bauk, Branka

“…Hepatitis C virus (HCV) persistently infects approximately 71 million people globally. To prevent infection a vaccine which elicits neutralizing antibodies…”
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Preclinical Development and Production of Virus-Like Particles As Vaccine Candidates for Hepatitis C by Masavuli, Makutiro Ghislain, Wijesundara, Danushka K, Torresi, Joseph, Gowans, Eric J, Grubor-Bauk, Branka

“…Hepatitis C Virus (HCV) infects 2% of the world's population and is the leading cause of liver disease and liver transplantation. It poses a serious and…”
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Emerging Targets for Developing T Cell-Mediated Vaccines for Human Immunodeficiency Virus (HIV)-1 by Wijesundara, Danushka K, Ranasinghe, Charani, Grubor-Bauk, Branka, Gowans, Eric J

“…Human immunodeficiency virus (HIV)-1 has infected >75 million individuals globally, and, according to the UN, is responsible for ~2.1 million new infections…”
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Enhanced T Cell Responses Induced by a Necrotic Dendritic Cell Vaccine, Expressing HCV NS3 by Mekonnen, Zelalem A, Masavuli, Makutiro G, Yu, Wenbo, Gummow, Jason, Whelan, Dawn M, Al-Delfi, Zahraa, Torresi, Joseph, Gowans, Eric J, Grubor-Bauk, Branka

“…A vaccine that induces potent, broad and sustained cell-mediated immunity, resulting in effective memory has the potential to restrict hepatitis C (HCV) virus…”
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Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine by Wijesundara, Danushka K., Yeow, Arthur, McMillan, Christopher L.D., Choo, Jovin J.Y., Todorovic, Aleksandra, Mekonnen, Zelalem A., Masavuli, Makutiro G., Young, Paul R., Gowans, Eric J., Grubor-Bauk, Branka, Muller, David A.

“…Zika virus (ZIKV) infections are spreading silently with limited global surveillance in at least 89 countries and territories. There is a pressing need to…”
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Long-term storage of DNA-free RNA for use in vaccine studies by Jones, Kathryn L, Drane, Debbie, Gowans, Eric J

“…RNA replicons represent potential vaccine delivery vehicles, but are considered too unstable for such use. This study examined the recovery, integrity and…”
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Hepatitis C Virus Nonstructural Protein 5B Is Involved in Virus Morphogenesis by GOUKLANI, Hamed, BULL, Rowena A, BEYER, Claudia, COULIBALY, Fasséli, GOWANS, Eric J, DRUMMER, Heidi E, NETTER, Hans J, WHITE, Peter A, HAQSHENAS, Gholamreza

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Cytolytic DNA vaccine encoding lytic perforin augments the maturation of- and antigen presentation by- dendritic cells in a time-dependent manner by Wijesundara, Danushka K., Yu, Wenbo, Quah, Ben J. C., Eldi, Preethi, Hayball, John D., Diener, Kerrilyn R., Voskoboinik, Ilia, Gowans, Eric J., Grubor-Bauk, Branka

“…The use of cost-effective vaccines capable of inducing robust CD8 + T cell immunity will contribute significantly towards the elimination of persistent viral…”
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Toward DNA-Based T-Cell Mediated Vaccines to Target HIV-1 and Hepatitis C Virus: Approaches to Elicit Localized Immunity for Protection by Mekonnen, Zelalem A, Grubor-Bauk, Branka, Masavuli, Makutiro G, Shrestha, Ashish C, Ranasinghe, Charani, Bull, Rowena A, Lloyd, Andrew R, Gowans, Eric J, Wijesundara, Danushka K

“…Human immunodeficiency virus (HIV)-1 and hepatitis C virus (HCV) are major contributors to the global disease burden with many experts recognizing the…”
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Cytolytic Perforin as an Adjuvant to Enhance the Immunogenicity of DNA Vaccines by Shrestha, Ashish C, Wijesundara, Danushka K, Masavuli, Makutiro G, Mekonnen, Zelalem A, Gowans, Eric J, Grubor-Bauk, Branka

“…DNA vaccines present one of the most cost-effective platforms to develop global vaccines, which have been tested for nearly three decades in preclinical and…”
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A phase I clinical trial of dendritic cell immunotherapy in HCV-infected individuals by Gowans, Eric J, Roberts, Stuart, Jones, Kathryn, Dinatale, Irene, Latour, Philippe A, Chua, Brendan, Eriksson, Emily M.Y, Chin, Ruth, Li, Shuo, Wall, Dominic M, Sparrow, Rosemary L, Moloney, Jude, Loudovaris, Maureen, Ffrench, Rosemary, Prince, H. Miles, Hart, Derek, Zeng, Weng, Torresi, Joseph, Brown, Lorena E, Jackson, David C

“…Background & Aims HCV patients who fail conventional interferon-based therapy have limited treatment options. Dendritic cells are central to the priming and…”
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Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection by Li, Shuo, Floess, Stefan, Hamann, Alf, Gaudieri, Silvana, Lucas, Andrew, Hellard, Margaret, Roberts, Stuart, Paukovic, Geza, Plebanski, Magdalena, Loveland, Bruce E, Aitken, Campbell, Barry, Simon, Schofield, Louis, Gowans, Eric J

“…We reported previously that a proportion of natural CD25(+) cells isolated from the PBMC of HCV patients can further upregulate CD25 expression in response to…”
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Safety Profile of a Multi-Antigenic DNA Vaccine Against Hepatitis C Virus by Gummow, Jason, Masavuli, Makutiro G, Mekonnen, Zelalem A, Li, Yanrui, Wijesundara, Danushka K, Shrestha, Ashish C, Voskoboinik, Ilia, Gowans, Eric J, Grubor-Bauk, Branka

“…Despite direct acting antivirals (DAAs) curing >95% of individuals infected with hepatitis C (HCV), in order to achieve the World Health Organization HCV…”
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Induction of multi-functional T cells in a phase I clinical trial of dendritic cell immunotherapy in hepatitis C virus infected individuals by Li, Shuo, Roberts, Stuart, Plebanski, Magdalena, Gouillou, Maelenn, Spelman, Tim, Latour, Philippe, Jackson, David, Brown, Lorena, Sparrow, Rosemary L, Prince, H Miles, Hart, Derek, Loveland, Bruce E, Gowans, Eric J

“…We have previously reported a world-first phase I clinical trial to treat HCV patients using monocyte-derived dendritic cells (Mo-DC) loaded with HCV-specific…”
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Surface display of IgG Fc on baculovirus vectors enhances binding to antigen-presenting cells and cell lines expressing Fc receptors by Martyn, John C, Cardin, Anthony J, Wines, Bruce D, Cendron, Angela, Li, Shuo, Mackenzie, Jason, Powell, Maree, Gowans, Eric J

“…Recombinant baculoviruses (recBV) were constructed with dual cassettes for constitutive expression of human IgG Fc following infection of insect cells and the…”
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Virus-Specific T-Cell Immunity Correlates with Control of GB Virus B Infection in Marmosets by WOOLLARD, David J, HAQSHENAS, Gholamreza, XUEBIN DONG, PRATT, Bridget F, KENT, Stephen J, GOWANS, Eric J

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IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling by Li, Shuo, Lefranc, Marie-Paule, Miles, John J., Alamyar, Eltaf, Giudicelli, Véronique, Duroux, Patrice, Freeman, J. Douglas, Corbin, Vincent D. A., Scheerlinck, Jean-Pierre, Frohman, Michael A., Cameron, Paul U., Plebanski, Magdalena, Loveland, Bruce, Burrows, Scott R., Papenfuss, Anthony T., Gowans, Eric J.

“…T cell repertoire diversity and clonotype follow-up in vaccination, cancer, infectious and immune diseases represent a major challenge owing to the enormous…”
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Natural Regulatory T Cells and Persistent Viral Infection by SHUO LI, GOWANS, Eric J, CHOUGNET, Claire, PLEBANSKI, Magdalena, DITTMER, Ulf

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Induction of Genotype Cross-Reactive, Hepatitis C Virus-Specific, Cell-Mediated Immunity in DNA-Vaccinated Mice by Wijesundara, Danushka K, Gummow, Jason, Li, Yanrui, Yu, Wenbo, Quah, Benjamin J, Ranasinghe, Charani, Torresi, Joseph, Gowans, Eric J, Grubor-Bauk, Branka

“…A universal hepatitis C virus (HCV) vaccine should elicit multiantigenic, multigenotypic responses, which are more likely to protect against challenge with the…”
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Single-Dose Vaccination with a Hepatotropic Adeno-associated Virus Efficiently Localizes T Cell Immunity in the Liver with the Potential To Confer Rapid Protection against Hepatitis C Virus by Mekonnen, Zelalem A, Grubor-Bauk, Branka, English, Kieran, Leung, Preston, Masavuli, Makutiro G, Shrestha, Ashish C, Bertolino, Patrick, Bowen, David G, Lloyd, Andrew R, Gowans, Eric J, Wijesundara, Danushka K

“…Hepatitis C virus (HCV) is a significant contributor to the global disease burden, and development of an effective vaccine is required to eliminate HCV…”
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