Search Results - "Gow, Jason M"

Substrate-dependent effects of human ABCB1 coding polymorphisms by Gow, Jason M, Hodges, Laura M, Chinn, Leslie W, Kroetz, Deanna L

“…One of the many obstacles to effective drug treatment is the efflux transporter P-glycoprotein (P-gp), which can restrict the plasma and intracellular…”
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Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation by Hesselson, Stephanie E, Matsson, Pär, Shima, James E, Fukushima, Hisayo, Yee, Sook Wah, Kobayashi, Yuya, Gow, Jason M, Ha, Connie, Ma, Benjamin, Poon, Annie, Johns, Susan J, Stryke, Doug, Castro, Richard A, Tahara, Harunobu, Choi, Ji Ha, Chen, Ligong, Picard, Nicolas, Sjödin, Elin, Roelofs, Maarke J E, Ferrin, Thomas E, Myers, Richard, Kroetz, Deanna L, Kwok, Pui-Yan, Giacomini, Kathleen M

“…Membrane transporters play crucial roles in the cellular uptake and efflux of an array of small molecules including nutrients, environmental toxins, and many…”
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Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein) by HODGES, Laura M, MARKOVA, Svetlana M, CHINN, Leslie W, GOW, Jason M, KROETZ, Deanna L, KLEIN, Teri E, ALTMAN, Russ B

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Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects by Gow, Jason M, Tsuji, Wayne H, Williams, Gary J, Mytych, Daniel, Sciberras, David, Searle, Shawn L, Mant, Tim, Gibbs, John P

“…Nerve growth factor plays a key role in the pathology of osteoarthritis (OA) related chronic pain. The aim of these studies was to evaluate the safety,…”
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Clinical pharmacology of AMG 181, a gut‐specific human anti‐α4β7 monoclonal antibody, for treating inflammatory bowel diseases by Pan, Wei‐Jian, Köck, Kathleen, Rees, William A., Sullivan, Barbara A., Evangelista, Christine M., Yen, Mark, Andrews, Jane M., Radford‐Smith, Graham L., Prince, Peter J., Reynhardt, Kaz O., Doherty, David R., Patel, Sonal K., Krill, Christine D., Zhou, Kefei, Shen, Jing, Smith, Lynn E., Gow, Jason M., Lee, Jonathan, Treacy, Anthony M., Yu, Zhigang, Platt, Virginia M., Borie, Dominic C.

“…Aims AMG 181 pharmacokinetics/pharmacodynamics (PK/PD), safety, tolerability and effects after single subcutaneous (s.c.) or intravenous (i.v.) administration…”
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PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network by Nguyen, Tan D, Gow, Jason M, Chinn, Leslie W, Kelly, Libusha, Jeong, Hotcherl, Huang, Conrad C, Stryke, Doug, Kawamoto, Michiko, Johns, Susan J, Carlson, Elaine, Taylor, Travis, Ferrin, Thomas E, Sali, Andrej, Giacomini, Kathleen M, Kroetz, Deanna L

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Functional hot spots in human ATP‐binding cassette transporter nucleotide binding domains by Kelly, Libusha, Fukushima, Hisayo, Karchin, Rachel, Gow, Jason M., Chinn, Leslie W., Pieper, Ursula, Segal, Mark R., Kroetz, Deanna L., Sali, Andrej

“…The human ATP‐binding cassette (ABC) transporter superfamily consists of 48 integral membrane proteins that couple the action of ATP binding and hydrolysis to…”
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The Effects of ABCB1 3'-Untranslated Region Variants on mRNA Stability by GOW, Jason M, CHINN, Leslie W, KROETZ, Deanna L

“…Genetic variation in ABCB1, encoding P-glycoprotein (P-gp), is a potential cause of interindividual variation in drug response. Numerous studies have focused…”
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Response to “Predictable difficulty or difficulty to predict” by Kelly, Libusha, Fukushima, Hisayo, Karchin, Rachel, Gow, Jason M., Chinn, Leslie W., Pieper, Ursula, Segal, Mark R., Kroetz, Deanna L., Sali, Andrej

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Very important pharmacogene summary by Hodges, Laura M, Markova, Svetlana M, Chinn, Leslie W, Gow, Jason M, Kroetz, Deanna L, Klein, Teri E, Altman, Russ B

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Interindividual variability in the effect of atazanavir and saquinavir on the expression of lymphocyte P-glycoprotein by Chinn, Leslie W., Gow, Jason M., Tse, Man Ming, Becker, Stephen L., Kroetz, Deanna L.

“…Objectives ABCB1 encodes the efflux transporter P-glycoprotein (P-gp), which regulates the intracellular concentration of many xenobiotics, including several…”
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Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression by Nguyen, T D, Markova, S, Liu, W, Gow, J M, Baldwin, R M, Habashian, M, Relling, M V, Ratain, M J, Kroetz, D L

“…Multidrug resistance protein 2 (MRP2, ABCC2) is an efflux membrane transporter highly expressed in liver, kidney and intestine with important physiological and…”
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Clinical pharmacology of AMG 181, a gut‐specific human anti‐α 4 β 7 monoclonal antibody, for treating inflammatory bowel diseases by Pan, Wei‐Jian, Köck, Kathleen, Rees, William A., Sullivan, Barbara A., Evangelista, Christine M., Yen, Mark, Andrews, Jane M., Radford‐Smith, Graham L., Prince, Peter J., Reynhardt, Kaz O., Doherty, David R., Patel, Sonal K., Krill, Christine D., Zhou, Kefei, Shen, Jing, Smith, Lynn E., Gow, Jason M., Lee, Jonathan, Treacy, Anthony M., Yu, Zhigang, Platt, Virginia M., Borie, Dominic C.

“…Aims AMG 181 pharmacokinetics/pharmacodynamics ( PK / PD ), safety, tolerability and effects after single subcutaneous (s.c.) or intravenous (i.v.)…”
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The Effects of ABCB1 3′-Untranslated Region Variants on mRNA Stability by Jason M. Gow, Leslie W. Chinn, Deanna L. Kroetz

“…Genetic variation in ABCB1 , encoding P-glycoprotein (P-gp), is a potential cause of interindividual variation in drug response. Numerous studies have focused…”
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Cellular and clinical effects of genetic variation in xenobiotic ABC transporters by Gow, Jason M

“…The xenobiotic ABC transporters are membrane bound proteins that efflux substrates coupled with ATP hydrolysis. These transporters have a broad substrate…”
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Cellular and clinical effects of genetic variation in xenobiotic ABC transporters by Gow, Jason M

“…The xenobiotic ABC transporters are membrane bound proteins that efflux substrates coupled with ATP hydrolysis. These transporters have a broad substrate…”
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