Search Results - "Govindarajan, Ramprakash"

Metabolism‘—Beyond the Preserve of Biological Sciences by Venkatesh, Govindarajan, Govindarajan, Ramprakash

“…Metabolism modeling is being adopted as a structured and systematic approach to analyses in colleges, universities, and research institutes in many parts of…”
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(-)-Phenserine and Inhibiting Pre-Programmed Cell Death: In Pursuit of a Novel Intervention for Alzheimer's Disease by Becker, Robert E, Greig, Nigel H, Lahiri, Debomoy K, Bledsoe, Joseph, Majercik, Sarah, Ballard, Clive, Aarsland, Dag, Schneider, Lon S, Flanagan, Douglas, Govindarajan, Ramprakash, Sano, Mary, Ferrucci, Luigi, Kapogiannis, Dimitrios

“…Concussion (mild) and other moderate traumatic brain injury (TBI) and Alzheimer's disease (AD) share overlapping neuropathologies, including neuronal…”
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Investigation of Spatial Heterogeneity of Salt Disproportionation in Tablets by Synchrotron X‑ray Diffractometry by Koranne, Sampada, Govindarajan, Ramprakash, Suryanarayanan, Raj

“…Tablets which were binary mixtures of pioglitazone hydrochloride (PioHCl) with magnesium stearate (MgSt), croscarmellose sodium (CCS), microcrystalline…”
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Gastroretentive Delivery Approach to Address pH-Dependent Degradation of (+)- and (-)-Phenserine by Verma, Pratishtha, Rezaei, Leyla, Govindarajan, Ramprakash, Greig, Nigel H., Donovan, Maureen D.

“…(-)-Phenserine (“phenserine”) and (+)-phenserine (posiphen; buntanetap) are longer-acting enantiomeric analogs of physostigmine with demonstrated promise in…”
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Structure in Dehydrated Trehalose Dihydrate—Evaluation of the Concept of Partial Crystallinity by Rani, Meena, Govindarajan, Ramprakash, Surana, Rahul, Suryanarayanan, Raj

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Water Worldwide: ‘Metabolism’—Beyond the Preserve of Biological Sciences by Govindarajan Venkatesh, Ramprakash Govindarajan

“…Metabolism modeling is being adopted as a structured and systematic approach to analyses in colleges, universities, and research institutes in many parts of…”
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Phase transformation in thiamine hydrochloride tablets: Influence on tablet microstructure, physical properties, and performance by Chakravarty, Paroma, Suryanarayanan, Raj, Govindarajan, Ramprakash

“…The objective of this article was to monitor phase transformation in thiamine hydrochloride, from a nonstoichiometric hydrate (NSH) to a hemihydrate (HH), in…”
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Investigation of solution and vapor phase mediated phase transformation in thiamine hydrochloride by Chakravarty, Paroma, Govindarajan, Ramprakash, Suryanarayanan, Raj

“…Thiamine hydrochloride (THCl) can exist as an anhydrate (AH), a hemihydrate (HH) and as a nonstoichiometric hydrate (NSH) where the water content can range…”
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Surface Acidity and Solid-State Compatibility of Excipients with an Acid-Sensitive API: Case Study of Atorvastatin Calcium by Govindarajan, Ramprakash, Landis, Margaret, Hancock, Bruno, Gatlin, Larry A., Suryanarayanan, Raj, Shalaev, Evgenyi Y.

“…The objectives of this study were to measure the apparent surface acidity of common excipients and to correlate the acidity with the chemical stability of an…”
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Ionization states in the microenvironment of solid dosage forms : Effect of formulation variables and processing by GOVINDARAJAN, Ramprakash, ZINCHUK, Andrey, HANCOCK, Bruno, SHALAEV, Evgenyi, SURYANARAYANAN, Raj

“…Evaluation of the effect of formulation composition and processing variables on the microenvironment in solid dosage forms, based on ionization of indicator…”
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Structure in dehydrated trehalose dihydrate : Evaluation of the concept of partial crystallinity by RANI, Meena, GOVINDARAJAN, Ramprakash, SURANA, Rahul, SURYANARAYANAN, Raj

“…(i) To use trehalose as a model compound to evaluate the concept of crystallinity in pharmaceuticals. (ii) To understand the structural nature of dehydrated…”
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Impact of freeze-drying on ionization of sulfonephthalein probe molecules in trehalose-citrate systems by Govindarajan, Ramprakash, Chatterjee, Koustuv, Gatlin, Larry, Suryanarayanan, Raj, Shalaev, Evgenyi Y

“…"pH memory," i.e., correlation between pH of solution before freeze-drying and chemical reactivity in the freeze-dried state, has been reported in many…”
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Insights into the dehydration behavior of thiamine hydrochloride (vitamin B1) hydrates: part I by Chakravarty, Paroma, Berendt, Robert T, Munson, Eric J, Young, Jr, Victor G, Govindarajan, Ramprakash, Suryanarayanan, Raj

“…Thiamine hydrochloride (Vitamin B(1), THCl) can exist as a nonstoichiometric hydrate (NSH) and as a hemihydrate (HH). NSH can contain up to approximately 1…”
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Insights into the dehydration behavior of thiamine hydrochloride (vitamin B1) hydrates: part II by Chakravarty, Paroma, Berendt, Robert T, Munson, Eric J, Young, Jr, Victor G, Govindarajan, Ramprakash, Suryanarayanan, Raj

“…Thiamine hydrochloride (THCl) can exist as an anhydrate (AH) and as a hemihydrate (HH). AH sorbs water as a function of environmental water vapor pressure to…”
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Correlation between chemical reactivity and the Hammett acidity function in amorphous solids using inversion of sucrose as a model reaction by Chatterjee, Koustuv, Shalaev, Evgenyi Y, Suryanarayanan, Raj, Govindarajan, Ramprakash

“…The goal was to evaluate the effects of acidity, expressed as the Hammett acidity function, on chemical reactivity in freeze-dried materials (lyophiles)…”
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Influence of preparation methodology on solid-state properties of an acidic drug-cyclodextrin system by Govindarajan, Ramprakash, Nagarsenker, Mangal S.

“…We have investigated the influence of processing variables on the solid‐state of a model drug, flurbiprofen, in cyclodextrin‐based systems and its effect on…”
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Formulation Studies and In Vivo Evaluation of a Flurbiprofen-Hydroxypropyl β-Cyclodextrin System by Govindarajan, Ramprakash, Nagarsenker, Mangal S

“…The purpose of this study was 1) to investigate in vivo advantages of a flurbiprofen (FPN)-hydroxypropyl β-cyclodextrin (HPβCD) solid dispersion (SD) in rats,…”
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The influence of measurement conditions on the Hammett acidity function of solid pharmaceutical excipients by Zinchuk, Andrey V., Hancock, Bruno C., Shalaev, Evgenyi Y., Reddy, Renuka D., Govindarajan, Ramprakash, Novak, Elizabeth

“…In this work the Hammett acidity function has been measured to assess the relative acidity of excipients used in the preparation of pharmaceutical solid dosage…”
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Formulation studies and in vivo evaluation of a flurbiprofen-hydroxypropyl β-cyclodextrin system by GOVINDARAJAN, Ramprakash, NAGARSENKER, Mangal S

“…The purpose of this study was 1) to investigate in vivo advantages of a flurbiprofen (FPN)-hydroxypropyl beta-cyclodextrin (HPbetaCD) solid dispersion (SD) in…”
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Basic Drug-Enterosoluble Polymer Coevaporates: Development of Oral Controlled Release Systems by Govindarajan, Ramprakash, Nagarsenker, Mangal S.

“…Precipitation of basic drugs within oral prolonged release systems, at the higher pH values of the intestine, would affect drug release. Coevaporates of a…”
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