Search Results - "Govender, Yashini"

The Current Evidence on the Association Between the Urinary Microbiome and Urinary Incontinence in Women by Govender, Yashini, Gabriel, Iwona, Minassian, Vatche, Fichorova, Raina

“…Urinary incontinence (UI) is a burdensome condition with high prevalence in middle-aged to older women and an unclear etiology. Advances in our understanding…”
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Medroxyprogesterone acetate, unlike norethisterone, increases HIV-1 replication in human peripheral blood mononuclear cells and an indicator cell line, via mechanisms involving the glucocorticoid receptor, increased CD4/CD8 ratios and CCR5 levels by Maritz, Michelle F, Ray, Roslyn M, Bick, Alexis J, Tomasicchio, Michele, Woodland, John G, Govender, Yashini, Avenant, Chanel, Hapgood, Janet P

“…High usage of progestin-only injectable contraceptives, which include the intramuscular injectables depo-medroxyprogesterone acetate (DMPA-IM, Depo-Provera)…”
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The Role of Small Extracellular Vesicles in Viral-Protozoan Symbiosis: Lessons From Trichomonasvirus in an Isogenic Host Parasite Model by Govender, Yashini, Chan, Tiffany, Yamamoto, Hidemi S, Budnik, Bogdan, Fichorova, Raina N

“…The protozoan parasite (TV), exclusively adapted to the human genital tract, is one of the most common sexually transmitted pathogens. Adding to the complexity…”
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Aberrant cervical innate immunity predicts onset of dysbiosis and sexually transmitted infections in women of reproductive age by Fichorova, Raina N, Morrison, Charles S, Chen, Pai-Lien, Yamamoto, Hidemi S, Govender, Yashini, Junaid, Damilola, Ryan, Stanthia, Kwok, Cynthia, Chipato, Tsungai, Salata, Robert A, Doncel, Gustavo F

“…Sexually transmitted infections (STIs) and vaginal dysbiosis (disturbed resident microbiota presenting with abnormal Nugent score or candidiasis) have been…”
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The injectable-only contraceptive medroxyprogesterone acetate, unlike norethisterone acetate and progesterone, regulates inflammatory genes in endocervical cells via the glucocorticoid receptor by Govender, Yashini, Avenant, Chanel, Verhoog, Nicolette J D, Ray, Roslyn M, Grantham, Nicholas J, Africander, Donita, Hapgood, Janet P

“…Clinical studies suggest that the injectable contraceptive medroxyprogesterone acetate (MPA) increases susceptibility to infections such as HIV-1, unlike the…”
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Systemic DPP4/CD26 is associated with natural HIV-1 control: Implications for COVID-19 susceptibility by Govender, Yashini, Shalekoff, Sharon, Ebrahim, Osman, Waja, Ziyaad, Chaisson, Richard E., Martinson, Neil, Tiemessen, Caroline T.

“…The current intersection of the COVID-19 and HIV-1 pandemics, has raised concerns about the risk for poor COVID-19 outcomes particularly in regions like…”
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Cervical and systemic innate immunity predictors of HIV risk linked to genital herpes acquisition and time from HSV-2 seroconversion by Govender, Yashini, Morrison, Charles S, Chen, Pai-Lien, Gao, Xiaoming, Yamamoto, Hidemi, Chipato, Tsungai, Anderson, Sharon, Barbieri, Robert, Salata, Robert, Doncel, Gustavo F, Fichorova, Raina Nakova

“…To examine innate immunity predictors of HIV-1 acquisition as biomarkers of HSV-2 risk and biological basis for epidemiologically established HIV-1…”
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Differential Glucocorticoid Receptor-Mediated Effects on Immunomodulatory Gene Expression by Progestin Contraceptives: Implications for HIV-1 Pathogenesis by Hapgood, Janet P., Ray, Roslyn M., Govender, Yashini, Avenant, Chanel, Tomasicchio, Michele

“…Whether hormonal contraceptives increase HIV‐1 acquisition, transmission and disease progression are critical questions. Clinical research has been hampered by…”
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The Injectable-Only Contraceptive Medroxyprogesterone Acetate, Unlike Norethisterone Acetate and Progesterone, Regulates Inflammatory Genes in Endocervical Cells via the Glucocorticoid Receptor: e96497 by Govender, Yashini, Avenant, Chanel, Verhoog, Nicolette JD, Ray, Roslyn M, Grantham, Nicholas J, Africander, Donita, Hapgood, Janet P

“…Clinical studies suggest that the injectable contraceptive medroxyprogesterone acetate (MPA) increases susceptibility to infections such as HIV-1, unlike the…”
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