Search Results - "Govande, Apurva"

STING cyclic dinucleotide sensing originated in bacteria by Morehouse, Benjamin R., Govande, Apurva A., Millman, Adi, Keszei, Alexander F. A., Lowey, Brianna, Ofir, Gal, Shao, Sichen, Sorek, Rotem, Kranzusch, Philip J.

“…Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic dinucleotides that are released during bacterial infection and…”
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Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates by Carey, Clayton M., Govande, Apurva A., Cooper, Juliane M., Hartley, Melissa K., Kranzusch, Philip J., Elde, Nels C.

“…Immune responses counteract infections but also cause collateral damage to hosts. Oligoadenylate synthetase 1 (OAS1) binds double-stranded RNA from invading…”
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Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense by Govande, Apurva A., Duncan-Lowey, Brianna, Eaglesham, James B., Whiteley, Aaron T., Kranzusch, Philip J.

“…cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzymes are signaling proteins that initiate antiviral immunity in animal cells and…”
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MYC Controls the Epstein-Barr Virus Lytic Switch by Guo, Rui, Jiang, Chang, Zhang, Yuchen, Govande, Apurva, Trudeau, Stephen J., Chen, Fang, Fry, Christopher J., Puri, Rishi, Wolinsky, Emma, Schineller, Molly, Frost, Thomas C., Gebre, Makda, Zhao, Bo, Giulino-Roth, Lisa, Doench, John G., Teng, Mingxiang, Gewurz, Benjamin E.

“…Epstein-Barr virus (EBV) is associated with multiple human malignancies. To evade immune detection, EBV switches between latent and lytic programs. How viral…”
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RNase L-activating 2′–5′ oligoadenylates bind ABCF1, ABCF3 and Decr-1 by Govande, Apurva A., Babnis, Aleksandra W., Urban, Christian, Habjan, Matthias, Hartmann, Rune, Kranzusch, Philip J., Pichlmair, Andreas

“…A notable signalling mechanism employed by mammalian innate immune signalling pathways uses nucleotide-based second messengers such as 2′3′-cGAMP and…”
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Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases by Mosallanejad, Kenta, Kennedy, Stephanie N, Bahleda, Kristin M, Slavik, Kailey M, Zhou, Wen, Govande, Apurva A, Hancks, Dustin C, Kranzusch, Philip J, Kagan, Jonathan C

“…The mechanisms by which innate immune receptors mediate self-nonself discrimination are unclear. In this study, we found species-specific molecular…”
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Mechanisms of Nucleotide Signaling in Bacterial and Metazoan Antiviral Defense by Govande, Apurva

“…Nucleotide-based antiviral signaling is broadly conserved between bacteria and metazoans. Mammalian cGAS and OAS1 are structurally homologous enzymes that…”
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