Search Results - "Govan, John RW"

Spread of a multiresistant strain of Pseudomonas aeruginosa in an adult cystic fibrosis clinic by Jones, Andrew M, Govan, John RW, Doherty, Catherine J, Dodd, Mary E, Isalska, Barbara J, Nigel Stanbridge, T, Kevin Webb, A

“…We initiated a prospective surveillance study to investigate possible Pseudomonas aeruginosa cross-infection in our cystic fibrosis centre. We characterised…”
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Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection by Govan, John R W, Brown, Alan R, Jones, Andrew M

“…The morbidity and mortality of patients with cystic fibrosis (CF) is primarily determined by chronic and debilitating lung infections caused by a surprisingly…”
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Analysis and Separation of Residues Important for the Chemoattractant and Antimicrobial Activities of β-Defensin 3 by Taylor, Karen, Clarke, David J., McCullough, Bryan, Chin, Wutharath, Seo, Emily, Yang, De, Oppenheim, Joost, Uhrin, Dusan, Govan, John R.W., Campopiano, Dominic J., MacMillan, Derek, Barran, Perdita, Dorin, Julia R.

“…β-Defensins are important in mammalian immunity displaying both antimicrobial and chemoattractant activities. Three canonical disulfide intramolecular bonds…”
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A Putative Gene Cluster for Aminoarabinose Biosynthesis Is Essential for Burkholderia cenocepacia Viability by ORTEGA, Ximena P, CARDONA, Silvia T, BROWN, Alan R, LOUTET, Slade A, FLANNAGAN, Ronald S, CAMPOPIANO, Dominic J, GOVAN, John R. W, VALVANO, Miguel A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Hypermutability in environmental Pseudomonas aeruginosa and in populations causing pulmonary infection in individuals with cystic fibrosis by Kenna, Dervla T, Doherty, Catherine J, Foweraker, Juliet, Macaskill, Lisa, Barcus, Victoria A, Govan, John R. W

“…1 Cystic Fibrosis Group, Centre for Infectious Diseases, University of Edinburgh Medical School, The Chancellor’s Building, 49 Little France Crescent,…”
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Contributions of two UDP-glucose dehydrogenases to viability and polymyxin B resistance of Burkholderia cenocepacia by Loutet, Slade A, Bartholdson, S. Josefin, Govan, John R. W, Campopiano, Dominic J, Valvano, Miguel A

“…1 Department of Microbiology and Immunology, Infectious Diseases Research Group, Siebens-Drake Research Institute, University of Western Ontario, London,…”
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Structure-activity relationships in defensin dimers: a novel link between beta-defensin tertiary structure and antimicrobial activity by Campopiano, Dominic J, Clarke, David J, Polfer, Nick C, Barran, Perdita E, Langley, Ross J, Govan, John R W, Maxwell, Alison, Dorin, Julia R

“…Defensins are cationic antimicrobial peptides that have a characteristic six-cysteine motif and are important components of the innate immune system. We…”
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Plant host and sugar alcohol induced exopolysaccharide biosynthesis in the Burkholderia cepacia complex by Bartholdson, S. Josefin, Brown, Alan R, Mewburn, Ben R, Clarke, David J, Fry, Stephen C, Campopiano, Dominic J, Govan, John R. W

“…1 School of Chemistry, University of Edinburgh, Edinburgh EH9 3JJ, UK 2 Centre for Infectious Diseases, University of Edinburgh, Edinburgh EH16 4SB, UK 3…”
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Spread of beta-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis clinic by Cheng, K, Smyth, R L, Govan, J R, Doherty, C, Winstanley, C, Denning, N, Heaf, D P, van Saene, H, Hart, C A

“…Pseudomonas aeruginosa colonisation of the airways of patients with cystic fibrosis (CF) is associated with considerable respiratory morbidity. Although…”
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Do processing time and storage of sputum influence quantitative bacteriology in bronchiectasis? by MURRAY, Maeve P, DOHERTY, Catherine J, GOVAN, John R. W, HILL, Adam T

“…This study aimed to establish whether the bacterial density of spontaneous sputum is affected by the time and mode of sample storage. Ten patients with…”
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Garlic Revisited: Antimicrobial Activity of Allicin-Containing Garlic Extracts against Burkholderia cepacia Complex: e112726 by Wallock-Richards, Daynea, Doherty, Catherine J, Doherty, Lynsey, Clarke, David J, Place, Marc, Govan, John RW, Campopiano, Dominic J

“…The antimicrobial activities of garlic and other plant alliums are primarily based on allicin, a thiosulphinate present in crushed garlic bulbs. We set out to…”
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Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo: e99029 by Beaumont, Paula E, McHugh, Brian, Findlay, Emily Gwyer, Mackellar, Annie, Mackenzie, Karen J, Gallo, Richard L, Govan, John RW, Simpson, A John, Davidson, Donald J

“…Cathelicidins are multifunctional cationic host-defence peptides (CHDP; also known as antimicrobial peptides) and an important component of innate host defence…”
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Covalent Dimer Species of {szligbeta}-Defensin Defr1 Display Potent Antimicrobial Activity against Multidrug-Resistant Bacterial Pathogens by Taylor, Karen, McCullough, Bryan, Clarke, David J, Langley, Ross J, Pechenick, Tali, Hill, Adrian, Campopiano, Dominic J, Barran, Perdita E, Dorin, Julia R, Govan, John RW

“…Beta defensins comprise a family of cationic, cysteine-rich antimicrobial peptides, predominantly expressed at epithelial surfaces. Previously we identified a…”
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Elusiveness of cysticfibrosis treatment by Littlewood, James M, Govan, John RW

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Mouse beta defensin-1 is a functional homolog of human beta defensin-1 by Morrison, G M, Davidson, D J, Kilanowski, F M, Borthwick, D W, Crook, K, Maxwell, A I, Govan, J R, Dorin, J R

“…Defensin are 3-4 kDa antimicrobial peptides of which three distinct families have been identified; alpha-defensin, beta-defensins, and insect defensins. Recent…”
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Pseudomonas aeruginosa cross-infection in cystic fibrosis by Jones, Andrew M, Webb, A Kevin, Govan, John RW, Hart, C Anthony, Walshaw, Martin J

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Lung pathology in response to repeated exposure to Staphylococcus aureus in congenic residual function cystic fibrosis mice does not increase in response to decreased CFTR levels or increased bacterial load by Davidson, Donald J, Webb, Sheila, Teague, Peter, Govan, John R W, Dorin, Julia R

“…To establish the role of defects in murine Cftr in the susceptibility to Staphylococcus aureus lung disease using mouse models of cystic fibrosis (CF),…”
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Temperate bacteriophages DK4 and BcepMu from Burkholderia cenocepacia J2315 are identical by Langley, Ross J., Kenna, Dervla, Bartholdson, Josefin, Campopiano, Dominic J., Govan, John R.W.

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Characteristics of sheep-rumen isolates of Pseudomonas aeruginosa inhibitory to the growth of Escherichia coli O157 by Duncan, Sylvia H., Doherty, Catherine J., Govan, John R.W., Neogrady, Susan, Galfi, Peter, Stewart, Colin S.

“…Abstract Screening facultative sheep-rumen bacteria which inhibit growth of Escherichia coli produced 11 strains of Pseudomonas aeruginosa. The isolates showed…”
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Sensitivity of the Burkholderia cepacia complex and Pseudomonas aeruginosa to transducing bacteriophages by Nzula, Sazini, Vandamme, Peter, Govan, John R.W.

“…Abstract Burkholderia cepacia is now recognised as a life-threatening pathogen among several groups of immunocompromised patients. In this context, the…”
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