Search Results - "Govan, John R.W."

Trappin-2 Promotes Early Clearance of Pseudomonas aeruginosa through CD14-Dependent Macrophage Activation and Neutrophil Recruitment by Wilkinson, Thomas S, Dhaliwal, Kevin, Hamilton, Thomas W, Lipka, Alexander F, Farrell, Lesley, Davidson, Donald J, Duffin, Rodger, Morris, Andrew Conway, Haslett, Chris, Govan, John R.W, Gregory, Christopher D, Sallenave, Jean-Michel, Simpson, A. John

“…Microaspiration of Pseudomonas aeruginosa contributes to the pathogenesis of nosocomial pneumonia. Trappin-2 is a host defense peptide that assists with the…”
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Analysis and Separation of Residues Important for the Chemoattractant and Antimicrobial Activities of β-Defensin 3 by Taylor, Karen, Clarke, David J., McCullough, Bryan, Chin, Wutharath, Seo, Emily, Yang, De, Oppenheim, Joost, Uhrin, Dusan, Govan, John R.W., Campopiano, Dominic J., MacMillan, Derek, Barran, Perdita, Dorin, Julia R.

“…β-Defensins are important in mammalian immunity displaying both antimicrobial and chemoattractant activities. Three canonical disulfide intramolecular bonds…”
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Antibiotic susceptibility testing in early and chronic respiratory infections with Pseudomonas aeruginosa by Foweraker, Juliet E, Govan, John R.W

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Vitamin-D deficiency is associated with chronic bacterial colonisation and disease severity in bronchiectasis by Chalmers, James D, McHugh, Brian J, Docherty, Catherine, Govan, John R W, Hill, Adam T

“…Vitamin-D deficiency has been linked to an increased risk of respiratory infections. The objective of this study was to determine the frequency and clinical…”
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Garlic revisited: antimicrobial activity of allicin-containing garlic extracts against Burkholderia cepacia complex by Wallock-Richards, Daynea, Doherty, Catherine J, Doherty, Lynsey, Clarke, David J, Place, Marc, Govan, John R W, Campopiano, Dominic J

“…The antimicrobial activities of garlic and other plant alliums are primarily based on allicin, a thiosulphinate present in crushed garlic bulbs. We set out to…”
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A Randomized Controlled Trial of Nebulized Gentamicin in Non―Cystic Fibrosis Bronchiectasis by MURRAY, Maeve P, GOVAN, John R. W, DOHERTY, Catherine J, SIMPSON, A. John, WILKINSON, Thomas S, CHALMERS, James D, GREENING, Andrew P, HASLETT, Christopher, HILL, Adam T

“…Bronchiectasis is a chronic debilitating disease with few evidence-based long-term treatments. A randomized controlled trial assessing the efficacy of…”
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Characteristics of sheep-rumen isolates of Pseudomonas aeruginosa inhibitory to the growth of Escherichia coli O157 by Duncan, Sylvia H, Doherty, Catherine J, Govan, John R.W, Neogrady, Susan, Galfi, Peter, Stewart, Colin S

“…Screening facultative sheep-rumen bacteria which inhibit growth of Escherichia coli produced 11 strains of Pseudomonas aeruginosa. The isolates showed three…”
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Lipopolysaccharide chemotypes of Burkholderia cepacia by Evans, Elwyn, Poxton, Ian R, Govan, John R.W

“…1 Department of Medical Microbiology, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG 2 Corresponding author: Dr. I. R. Poxton (e-mail:…”
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A Randomized Controlled Trial of Atorvastatin in Patients With Bronchiectasis Infected With Pseudomonas Aeruginosa: A Proof of Concept Study by Bedi, Pallavi, Chalmers, James D, Graham, Catriona, Clarke, Andrea, Donaldson, Samantha, Doherty, Catherine, Govan, John R W, Davidson, Donald J, Rossi, Adriano G, Hill, Adam T

“…There are no randomized controlled trials of statin therapy in patients with severe bronchiectasis who are chronically infected with Pseudomonas aeruginosa…”
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Cathelicidin host defence peptide augments clearance of pulmonary Pseudomonas aeruginosa infection by its influence on neutrophil function in vivo by Beaumont, Paula E, McHugh, Brian, Gwyer Findlay, Emily, Mackellar, Annie, Mackenzie, Karen J, Gallo, Richard L, Govan, John R W, Simpson, A John, Davidson, Donald J

“…Cathelicidins are multifunctional cationic host-defence peptides (CHDP; also known as antimicrobial peptides) and an important component of innate host defence…”
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A Randomized Controlled Trial of Atorvastatin in Patients With Bronchiectasis Infected With Pseudomonas Aeruginosa by Bedi, Pallavi, Chalmers, James D., Graham, Catriona, Clarke, Andrea, Donaldson, Samantha, Doherty, Catherine, Govan, John R.W., Davidson, Donald J., Rossi, Adriano G., Hill, Adam T.

“…There are no randomized controlled trials of statin therapy in patients with severe bronchiectasis who are chronically infected with Pseudomonas aeruginosa…”
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Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection by Govan, John R W, Brown, Alan R, Jones, Andrew M

“…The morbidity and mortality of patients with cystic fibrosis (CF) is primarily determined by chronic and debilitating lung infections caused by a surprisingly…”
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The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium by Barlow, Peter G, Beaumont, Paula E, Cosseau, Celine, Mackellar, Annie, Wilkinson, Thomas S, Hancock, Robert E W, Haslett, Chris, Govan, John R W, Simpson, A John, Davidson, Donald J

“…Cationic host defense peptides are key, evolutionarily conserved components of the innate immune system. The human cathelicidin LL-37 is an important cationic…”
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Endotoxic activity of lipopolysaccharides isolated from emergent potential cystic fibrosis pathogens by Hutchison, Michael L, Bonell, Emma C, Poxton, Ian R, Govan, John R.W

“…Improved antimicrobial therapies against the classical spectrum of pathogenic bacteria which colonise the lungs of cystic fibrosis (CF) patients has resulted…”
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Lack of correlation between O-serotype, bacteriophage susceptibility and genomovar status in the Burkholderia cepacia complex by Kenna, Dervla T, Barcus, Victoria A, Langley, Ross J, Vandamme, Peter, Govan, John R.W

“…The Burkholderia cepacia complex comprises at least nine phylogenetically related genomic species (genomovars) which cause life-threatening infection in…”
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Characteristics of sheep-rumen isolates of Pseudomonas aeruginosa inhibitory to the growth of Escherichia coli O157 by Duncan, Sylvia H., Doherty, Catherine J., Govan, John R.W., Neogrady, Susan, Galfi, Peter, Stewart, Colin S.

“…Abstract Screening facultative sheep-rumen bacteria which inhibit growth of Escherichia coli produced 11 strains of Pseudomonas aeruginosa. The isolates showed…”
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Clinical outcome for cystic fibrosis patients infected with transmissible pseudomonas aeruginosa: an 8-year prospective study by Jones, Andrew M, Dodd, Mary E, Morris, Julie, Doherty, Cathy, Govan, John R W, Webb, A Kevin

“…Although there is now compelling evidence for cross-infection by strains of Pseudomonas aeruginosa at some specialist (cystic fibrosis [CF]) centers, the…”
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A Putative Gene Cluster for Aminoarabinose Biosynthesis Is Essential for Burkholderia cenocepacia Viability by ORTEGA, Ximena P, CARDONA, Silvia T, BROWN, Alan R, LOUTET, Slade A, FLANNAGAN, Ronald S, CAMPOPIANO, Dominic J, GOVAN, John R. W, VALVANO, Miguel A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Burkholderia cepacia in Cystic Fibrosis by Mahenthiralingam, E, Campbell, M, Speert, D P

“…To the Editor: Steinbach et al. (Oct. 13 issue) 1 address an important and contentious issue — the transmissibility of Burkholderia (formerly Pseudomonas )…”
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Burkholderia cenocepacia sp. nov.—a new twist to an old story by Vandamme, Peter, Holmes, Barry, Coenye, Tom, Goris, Johan, Mahenthiralingam, Eshwar, LiPuma, John J., Govan, John R.W.

“…DNA–DNA hybridisation experiments between isolates representing Burkholderia cepacia genomovar III recA lineages IIIA and IIIB reinforced the classification of…”
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