Search Results - "Gouveia, H"

Unappreciated subcontinental admixture in Europeans and European Americans and implications for genetic epidemiology studies by Gouveia, Mateus H., Bentley, Amy R., Leal, Thiago P., Tarazona-Santos, Eduardo, Bustamante, Carlos D., Adeyemo, Adebowale A., Rotimi, Charles N., Shriner, Daniel

“…European-ancestry populations are recognized as stratified but not as admixed, implying that residual confounding by locus-specific ancestry can affect studies…”
Get full text

Editorial: Genomic Ancestry and Biological Traits by Rodrigues-Soares, Fernanda, Kehdy, Fernanda S. G., Gouveia, Mateus H.

Get full text

Genetic differentiation in East African ethnicities and its relationship with endurance running success by Zani, André L S, Gouveia, Mateus H, Aquino, Marla M, Quevedo, Rodrigo, Menezes, Rodrigo L, Rotimi, Charles, Lwande, Gerald O, Ouma, Collins, Mekonnen, Ephrem, Fagundes, Nelson J R

“…Since the 1960s, East African athletes, mainly from Kenya and Ethiopia, have dominated long-distance running events in both the male and female categories…”
Get full text

Early Changes in Postprandial Gallbladder Emptying in Morbidly Obese Patients Undergoing Roux-en-Y Gastric Bypass: Correlation with the Occurrence of Biliary Sludge and Gallstones by Bastouly, Michel, Arasaki, Carlos Haruo, Ferreira, Jael Brasil, Zanoto, Arnaldo, Borges, Fabíola Gouveia H. P., Del Grande, José Carlos

“…Background Gallstones have been frequently diagnosed after Roux-en-Y gastric bypass (RYGBP). Gallbladder stasis associated with duodenal exclusion may play a…”
Get full text

Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits by Gouveia, Mateus H., Bentley, Amy R., Leonard, Hampton, Meeks, Karlijn A. C., Ekoru, Kenneth, Chen, Guanjie, Nalls, Michael A., Simonsick, Eleanor M., Tarazona-Santos, Eduardo, Lima-Costa, Maria Fernanda, Adeyemo, Adebowale, Shriner, Daniel, Rotimi, Charles N.

“…Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS…”
Get full text

Untargeted metabolomic profiling reveals molecular signatures associated with type 2 diabetes in Nigerians by Doumatey, Ayo P, Shriner, Daniel, Zhou, Jie, Lei, Lin, Chen, Guanjie, Oluwasola-Taiwo, Omolara, Nkem, Susan, Ogundeji, Adela, Adebamowo, Sally N, Bentley, Amy R, Gouveia, Mateus H, Meeks, Karlijn A C, Adebamowo, Clement A, Adeyemo, Adebowale A, Rotimi, Charles N

“…Type 2 diabetes (T2D) has reached epidemic proportions globally, including in Africa. However, molecular studies to understand the pathophysiology of T2D…”
Get full text

β1 Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice by Ueta, Cintia B, Fernandes, Gustavo W, Capelo, Luciane P, Fonseca, Tatiane L, Maculan, Flávia D'Angelo, Gouveia, Cecilia H A, Brum, Patrícia C, Christoffolete, Marcelo A, Aoki, Marcelo S, Lancellotti, Carmen L, Kim, Brian, Bianco, Antonio C, Ribeiro, Miriam O

“…Brown adipose tissue (BAT) is predominantly regulated by the sympathetic nervous system (SNS) and the adrenergic receptor signaling pathway. Knowing that a…”
Get full text

Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits by Meeks, Karlijn A C, Bentley, Amy R, Gouveia, Mateus H, Chen, Guanjie, Zhou, Jie, Lei, Lin, Adeyemo, Adebowale A, Doumatey, Ayo P, Rotimi, Charles N

“…A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2…”
Get full text

Putative pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations by Bezerra, Ohanna Cavalcanti de Lima, Alvarado-Arnez, Lucia Elena, Mabunda, Nédio, Salomé, Graça, de Sousa, Amina, Kehdy, Fernanda de Souza Gomes, Sales-Marques, Carolinne, Manta, Fernanda Saloum de Neves, Andrade, Rafaela Mota, Ferreira, Laís Pereira, Leal-Calvo, Thyago, Cardoso, Cynthia Chester, Nunes, Kelly, Gouveia, Mateus H, Mbulaiteve, Sam M, Yeboah, Edward D, Hsing, Ann, Latini, Ana Carla Pereira, Leturiondo, André Luiz, Rodrigues, Fabíola da Costa, Noronha, Ariani Batista, Ferreira, Cynthia de Oliveira, Talhari, Carolina, Rêgo, Jamile Leão, Castellucci, Léa Cristina de Carvalho, Tarazona-Santos, Eduardo, Carvalho, Elizeu Fagundes de, Meyer, Diogo, Pinheiro, Roberta Olmo, Jani, Ilesh V, Pacheco, Antonio Guilherme, Moraes, Milton Ozório

“…Pyruvate kinase (PK), encoded by the PKLR gene, is a key player in glycolysis controlling the integrity of erythrocytes. Due to Plasmodium selection, mutations…”
Get full text

Thyroid hormone receptor β-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats by Villicev, Cássio M, Freitas, Fatima R S, Aoki, Marcelo S, Taffarel, Cássio, Scanlan, Thomas S, Moriscot, Anselmo S, Ribeiro, Miriam O, Bianco, Antonio C, Gouveia, Cecília H A

“…It is well known that thyroid hormone affects body composition; however, the effect of the thyroid hormone receptor β (TRβ)-selective thyromimetic GC-1 on this…”
Get full text

Universal genome-wide association studies: Powerful joint ancestry and association testing by Shriner, Daniel, Bentley, Amy R., Gouveia, Mateus H., Heuston, Elisabeth F., Doumatey, Ayo P., Chen, Guanjie, Zhou, Jie, Adeyemo, Adebowale, Rotimi, Charles N.

“…The vast majority of human populations and individuals have mixed ancestry. Consequently, adjustment for locus-specific ancestry is essential for genetic…”
Get full text

Evaluating the Causal Link Between Malaria Infection and Endemic Burkitt Lymphoma in Northern Uganda: A Mendelian Randomization Study by Legason, Ismail D., Pfeiffer, Ruth M., Udquim, Krizia-Ivana, Bergen, Andrew W., Gouveia, Mateus H., Kirimunda, Samuel, Otim, Isaac, Karlins, Eric, Kerchan, Patrick, Nabalende, Hadijah, Bayanjargal, Ariunaa, Emmanuel, Benjamin, Kagwa, Paul, Talisuna, Ambrose O., Bhatia, Kishor, Yeager, Meredith, Biggar, Robert J., Ayers, Leona W., Reynolds, Steven J., Goedert, James J., Ogwang, Martin D., Fraumeni, Joseph F., Prokunina-Olsson, Ludmila, Mbulaiteye, Sam M.

“…Plasmodium falciparum (Pf) malaria infection is suspected to cause endemic Burkitt Lymphoma (eBL), but the evidence remains unsettled. An inverse relationship…”
Get full text

P-196Gastrointestinal stromal tumors: Fifteen years of experience in a Portuguese Hospital Centre by Lopes, S, Gouveia, H, Pinho, M, Oliveira, S, Cunha, J, Godinho, J, Faria Ana, L, Macedo, J, Santos, P

Get full text

Double disruption of α2A‐ and α2C ‐adrenoceptors results in sympathetic hyperactivity and high‐bone‐mass phenotype by Fonseca, Tatiana L, Jorgetti, Vanda, Costa, Cristiane C, Capelo, Luciane P, Covarrubias, Ambart E, Moulatlet, Ana C, Teixeira, Marilia B, Hesse, Eric, Morethson, Priscilla, Beber, Eduardo H, Freitas, Fatima R, Wang, Charles C, Nonaka, Keico O, Oliveira, Ricardo, Casarini, Dulce E, Zorn, Telma M, Brum, Patricia C, Gouveia, Cecilia H

“…Evidence demonstrates that sympathetic nervous system (SNS) activation causes osteopenia via β2‐adrenoceptor (β2‐AR) signaling. Here we show that female mice…”
Get full text

Inactivation of the adrenergic receptor β2 disrupts glucose homeostasis in mice by Fernandes, Gustavo W, Ueta, Cintia B, Fonseca, Tatiane L, Gouveia, Cecilia H A, Lancellotti, Carmen L, Brum, Patrícia C, Christoffolete, Marcelo A, Bianco, Antonio C, Ribeiro, Miriam O

“…Three types of beta adrenergic receptors (ARβ1–3) mediate the sympathetic activation of brown adipose tissue (BAT), the key thermogenic site for mice which is…”
Get full text

Marked Disturbance of Calcium Homeostasis in Mice With Targeted Disruption of the Trpv6 Calcium Channel Gene by Bianco, Suzy DC, Peng, Ji‐Bin, Takanaga, Hitomi, Suzuki, Yoshiro, Crescenzi, Alessandra, Kos, Claudine H, Zhuang, Liyan, Freeman, Michael R, Gouveia, Cecilia HA, Wu, Jiangping, Luo, Hongyu, Mauro, Theodora, Brown, Edward M, Hediger, Matthias A

“…We report the phenotype of mice with targeted disruption of the Trpv6 (Trpv6 KO) epithelial calcium channel. The mice exhibit disordered Ca2+ homeostasis,…”
Get full text

Abnormal Thyroid Hormone Status Differentially Affects Bone Mass Accrual and Bone Strength in C3H/HeJ Mice: A Mouse Model of Type I Deiodinase Deficiency by Zaitune, Clarissa R, Fonseca, Tatiana L, Capelo, Luciane P, Freitas, Fatima R, Beber, Eduardo H, Dora, José M, Wang, Charles C, Miranda-Rodrigues, Manuela, Nonaka, Keico O, Maia, Ana L, Gouveia, Cecilia H A

“…C3H/HeJ (C3H) mice are deficient of type I deiodinase (D1), an enzyme that activates thyroid hormone (TH), converting thyroxine (T4) to triiodothyronine (T3)…”
Get full text

Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton by Capelo, Luciane P, Beber, Eduardo H, Huang, Stephen A, Zorn, Telma M.T, Bianco, Antonio C, Gouveia, Cecília H.A

“…Abstract Thyroid hormone (TH) plays a key role on post-natal bone development and metabolism, while its relevance during fetal bone development is uncertain…”
Get full text

Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone by Martins, Gisele M, Teixeira, Marília B C G, Silva, Marcos V, Neofiti-Papi, Bianca, Miranda-Rodrigues, Manuela, Brum, Patricia C, Gouveia, Cecilia H A

“…Evidence shows that sympathetic nervous system (SNS) activation inhibits bone formation and activates bone resorption leading to bone loss. Because thyroid…”
Get full text

Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt" by Gouveia, Mateus H, Bergen, Andrew W, Borda, Victor, Nunes, Kelly, Leal, Thiago P, Ogwang, Martin D, Yeboah, Edward D, Mensah, James E, Kinyera, Tobias, Otim, Isaac, Nabalende, Hadijah, Legason, Ismail D, Mpoloka, Sununguko Wata, Mokone, Gaonyadiwe George, Kerchan, Patrick, Bhatia, Kishor, Reynolds, Steven J, Birtwum, Richard B, Adjei, Andrew A, Tettey, Yao, Tay, Evelyn, Hoover, Robert, Pfeiffer, Ruth M, Biggar, Robert J, Goedert, James J, Prokunina-Olsson, Ludmila, Dean, Michael, Yeager, Meredith, Lima-Costa, M Fernanda, Hsing, Ann W, Tishkoff, Sarah A, Chanock, Stephen J, Tarazona-Santos, Eduardo, Mbulaiteye, Sam M

“…Populations in sub-Saharan Africa have historically been exposed to intense selection from chronic infection with falciparum malaria. Interestingly,…”
Get full text