Search Results - "Gouveia, Cecília H.A"

Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton by Capelo, Luciane P, Beber, Eduardo H, Huang, Stephen A, Zorn, Telma M.T, Bianco, Antonio C, Gouveia, Cecília H.A

“…Abstract Thyroid hormone (TH) plays a key role on post-natal bone development and metabolism, while its relevance during fetal bone development is uncertain…”
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The monocarboxylate transporter 8 and L-type amino acid transporters 1 and 2 are expressed in mouse skeletons and in osteoblastic MC3T3-E1 cells by Capelo, Luciane P, Beber, Eduardo H, Fonseca, Tatiana L, Gouveia, Cecilia H A

“…Several plasma membrane transporters have been shown to mediate the cellular influx and/or efflux of iodothyronines, including the sodium-independent organic…”
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Thyroid hormone receptor β-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats by Villicev, Cássio M, Freitas, Fatima R S, Aoki, Marcelo S, Taffarel, Cássio, Scanlan, Thomas S, Moriscot, Anselmo S, Ribeiro, Miriam O, Bianco, Antonio C, Gouveia, Cecília H A

“…It is well known that thyroid hormone affects body composition; however, the effect of the thyroid hormone receptor β (TRβ)-selective thyromimetic GC-1 on this…”
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Thyroid Hormone and Skeletal Development by Gouveia, Cecilia H A, Miranda-Rodrigues, Manuela, Martins, Gisele M, Neofiti-Papi, Bianca

“…Thyroid hormone (TH) is essential for skeletal development from the late fetal life to the onset of puberty. During this large window of actions, TH has key…”
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Marked Disturbance of Calcium Homeostasis in Mice With Targeted Disruption of the Trpv6 Calcium Channel Gene by Bianco, Suzy DC, Peng, Ji‐Bin, Takanaga, Hitomi, Suzuki, Yoshiro, Crescenzi, Alessandra, Kos, Claudine H, Zhuang, Liyan, Freeman, Michael R, Gouveia, Cecilia HA, Wu, Jiangping, Luo, Hongyu, Mauro, Theodora, Brown, Edward M, Hediger, Matthias A

“…We report the phenotype of mice with targeted disruption of the Trpv6 (Trpv6 KO) epithelial calcium channel. The mice exhibit disordered Ca2+ homeostasis,…”
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β1 Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice by Ueta, Cintia B, Fernandes, Gustavo W, Capelo, Luciane P, Fonseca, Tatiane L, Maculan, Flávia D'Angelo, Gouveia, Cecilia H A, Brum, Patrícia C, Christoffolete, Marcelo A, Aoki, Marcelo S, Lancellotti, Carmen L, Kim, Brian, Bianco, Antonio C, Ribeiro, Miriam O

“…Brown adipose tissue (BAT) is predominantly regulated by the sympathetic nervous system (SNS) and the adrenergic receptor signaling pathway. Knowing that a…”
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Inactivation of the adrenergic receptor β2 disrupts glucose homeostasis in mice by Fernandes, Gustavo W, Ueta, Cintia B, Fonseca, Tatiane L, Gouveia, Cecilia H A, Lancellotti, Carmen L, Brum, Patrícia C, Christoffolete, Marcelo A, Bianco, Antonio C, Ribeiro, Miriam O

“…Three types of beta adrenergic receptors (ARβ1–3) mediate the sympathetic activation of brown adipose tissue (BAT), the key thermogenic site for mice which is…”
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Thyroid hormone interacts with the sympathetic nervous system to modulate bone mass and structure in young adult mice by Fonseca, Tatiana L, Teixeira, Marilia B C G, Miranda-Rodrigues, Manuela, Rodrigues-Miranda, Manuela, Silva, Marcos V, Martins, Gisele M, Costa, Cristiane C, Arita, Danielle Y, Perez, Juliana D, Casarini, Dulce E, Brum, Patricia C, Gouveia, Cecilia H A

“…To investigate whether thyroid hormone (TH) interacts with the sympathetic nervous system (SNS) to modulate bone mass and structure, we studied the effects of…”
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Abnormal Thyroid Hormone Status Differentially Affects Bone Mass Accrual and Bone Strength in C3H/HeJ Mice: A Mouse Model of Type I Deiodinase Deficiency by Zaitune, Clarissa R, Fonseca, Tatiana L, Capelo, Luciane P, Freitas, Fatima R, Beber, Eduardo H, Dora, José M, Wang, Charles C, Miranda-Rodrigues, Manuela, Nonaka, Keico O, Maia, Ana L, Gouveia, Cecilia H A

“…C3H/HeJ (C3H) mice are deficient of type I deiodinase (D1), an enzyme that activates thyroid hormone (TH), converting thyroxine (T4) to triiodothyronine (T3)…”
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Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone by Martins, Gisele M, Teixeira, Marília B C G, Silva, Marcos V, Neofiti-Papi, Bianca, Miranda-Rodrigues, Manuela, Brum, Patricia C, Gouveia, Cecilia H A

“…Evidence shows that sympathetic nervous system (SNS) activation inhibits bone formation and activates bone resorption leading to bone loss. Because thyroid…”
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O efeito molecular e estrutural do hormônio tiroideano no esqueleto by Gouveia, Cecília H.A.

“…O hormônio tiroideano é essencial para o desenvolvimento, maturação e metabolismo ósseos normais. Durante o desenvolvimento, a deficiência do hormônio…”
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The Thyroid Hormone Receptor (TR) β-Selective Agonist GC-1 Inhibits Proliferation But Induces Differentiation and TR β mRNA Expression in Mouse and Rat Osteoblast-Like Cells by Beber, Eduardo H., Capelo, Luciane P., Fonseca, Tatiana L., Costa, Cristiane C., Lotfi, Claudimara F., Scanlan, Thomas S., Gouveia, Cecilia H. A.

“…Previous studies showed anabolic effects of GC-1, a triiodothyronine (T3) analogue that is selective for both binding and activation functions of thyroid…”
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Type 2 Iodothyronine Selenodeiodinase Is Expressed throughout the Mouse Skeleton and in the MC3T3-E1 Mouse Osteoblastic Cell Line during Differentiation by Gouveia, Cecilia H. A, Christoffolete, Marcelo A, Zaitune, Clarissa R, Dora, José Miguel, Harney, John W, Maia, Ana Luiza, Bianco, Antonio C

“…Thyroid hormone affects multiple aspects of bone metabolism, but little is known about thyroid hormone deiodination in bone cells except that cultures of…”
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The Thyroid Hormone Receptor β‐Specific Agonist GC‐1 Selectively Affects the Bone Development of Hypothyroid Rats by Freitas, Fatima RS, Capelo, Luciane P, O'Shea, Patrick J, Jorgetti, Vanda, Moriscot, Anselmo S, Scanlan, Thomas S, Williams, Graham R, Zorn, Telma MT, Gouveia, Cecilia HA

“…We investigated the effects of GC‐1, a TRβ‐selective thyromimetic, on bone development of hypothyroid rats. Whereas T3 reverted the IGF‐I deficiency and the…”
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Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1 by Freitas, Fatima R S, Moriscot, Anselmo S, Jorgetti, Vanda, Soares, Antonio G, Passarelli, Marisa, Scanlan, Thomas S, Brent, Gregory A, Bianco, Antonio C, Gouveia, Cecilia H A

“…Thyrotoxicosis is frequently associated with increased bone turnover and decreased bone mass. To investigate the role of thyroid hormone receptor-beta (TR…”
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O efeito molecular e estrutural do hormônio tiroideano no esqueleto by Gouveia, Cecília H.A.

“…O hormônio tiroideano é essencial para o desenvolvimento, maturação e metabolismo ósseos normais. Durante o desenvolvimento, a deficiência do hormônio…”
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Effects of Thyroid Hormone Administration and Estrogen Deficiency on Bone Mass of Female Rats by Gouveia, Cecilia H. A., Jorgetti, Vanda, Bianco, Antonio C.

“…To investigate the effects of thyroxine (T4) administration on bone mass, five 81‐day‐old female rats were treated with T4 (25 μg of T4/100 g of body weight…”
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Morphometric Dual‐Energy X‐Ray Absorptiometry of the Spine: Report of a Large Series and Correlation with Axial Bone Mineral Density by Bianco, Antonio C., Malvestiti, Luiz F., Gouveia, Cecilia H. A., Wehba, Salim, Lewin, Shlomo, Marone, Marilia M. S.

“…We studied vertebral morphometry and its relation to bone mineral density (BMD) in normal Brazilian women (n = 605). All women (age 22–97 years) were…”
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