Search Results - "Gout, Peter W"

Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite? by Choi, Stephen Yiu Chuen, Collins, Colin C, Gout, Peter W, Wang, Yuzhuo

“…The common preference of cancers for lactic acid‐generating metabolic energy pathways has led to proposals that their reprogrammed metabolism confers growth…”
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The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases by Lo, Maisie, Wang, Yu-Zhuo, Gout, Peter W

“…The x(c) (-) cystine/glutamate antiporter is a major plasma membrane transporter for the cellular uptake of cystine in exchange for intracellular glutamate…”
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High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development by DONG LIN, WYATT, Alexander W, BELL, Robert H, ANDERSON, Shawn, HURTADO-COLL, Antonio, FAZLI, Ladan, SHARMA, Manju, BELTRAN, Himisha, RUBIN, Mark, COX, Michael, GOUT, Peter W, MORRIS, James, HUI XUE, GOLDENBERG, Larry, VOLIK, Stanislav V, GLEAVE, Martin E, COLLINS, Colin C, YUZHUO WANG, YUWEI WANG, XIN DONG, HAEGERT, Anne, WU, Rebecca, BRAHMBHATT, Sonal, FAN MO, JONG, Lina

“…Standardized and reproducible preclinical models that recapitulate the dynamics of prostate cancer are urgently needed. We established a bank of transplantable…”
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Elevated expression of the centromere protein‐A(CENP‐A)‐encoding gene as a prognostic and predictive biomarker in human cancers by Sun, Xia, Clermont, Pier‐Luc, Jiao, Wenlin, Helgason, Cheryl D., Gout, Peter W., Wang, Yuzhuo, Qu, Sifeng

“…Centromere protein‐A (CENP‐A), a histone‐H3 variant, plays an essential role in cell division by ensuring proper formation and function of centromeres and…”
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MicroRNAs associated with metastatic prostate cancer by Watahiki, Akira, Wang, Yuwei, Morris, James, Dennis, Kristopher, O'Dwyer, Helena M, Gleave, Martin, Gout, Peter W, Wang, Yuzhuo

“…Metastasis is the most common cause of death of prostate cancer patients. Identification of specific metastasis biomarkers and novel therapeutic targets is…”
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Patient-Derived First Generation Xenografts of Non-Small Cell Lung Cancers: Promising Tools for Predicting Drug Responses for Personalized Chemotherapy by XIN DONG, JUN GUAN, LAM, Wan L, LASKIN, Janessa, LING, Victor, LAM, Stephen, YUZHUO WANG, ENGLISH, John C, FLINT, Julia, YEE, John, EVANS, Kenneth, MURRAY, Nevin, MACAULAY, Calum, NG, Raymond T, GOUT, Peter W

“…Current chemotherapeutic regimens have only modest benefit for non-small cell lung cancer (NSCLC) patients. Cumulative toxicities/drug resistance limit…”
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Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer by Hao, Jun, Ci, Xinpei, Xue, Hui, Wu, Rebecca, Dong, Xin, Choi, Stephen Yiu Chuen, He, Haiqing, Wang, Yu, Zhang, Fang, Qu, Sifeng, Zhang, Fan, Haegert, Anne M., Gout, Peter W., Zoubeidi, Amina, Collins, Colin, Gleave, Martin E., Lin, Dong, Wang, Yuzhuo

“…Although androgen deprivation therapy is initially effective in controlling growth of hormone-naive prostate cancers (HNPCs) in patients, currently incurable…”
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Targeting MCT4 to reduce lactic acid secretion and glycolysis for treatment of neuroendocrine prostate cancer by Choi, Stephen Yiu Chuen, Ettinger, Susan L., Lin, Dong, Xue, Hui, Ci, Xinpei, Nabavi, Noushin, Bell, Robert H., Mo, Fan, Gout, Peter W., Fleshner, Neil E., Gleave, Martin E., Collins, Colin C., Wang, Yuzhuo

“…Development of neuroendocrine prostate cancer (NEPC) is emerging as a major problem in clinical management of advanced prostate cancer (PCa). As increasingly…”
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Pre-clinical Models for Malignant Mesothelioma Research: From Chemical-Induced to Patient-Derived Cancer Xenografts by Nabavi, Noushin, Wei, Jingchao, Lin, Dong, Collins, Colin C, Gout, Peter W, Wang, Yuzhuo

“…Malignant mesothelioma (MM) is a rare disease often associated with environmental exposure to asbestos and other erionite fibers. MM has a long latency period…”
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Potential Therapies for Infectious Diseases Based on Targeting Immune Evasion Mechanisms That Pathogens Have in Common With Cancer Cells by Wong, Jodi, Choi, Stephen Yiu Chuen, Liu, Rongrong, Xu, Eddie, Killam, James, Gout, Peter W, Wang, Yuzhuo

“…Many global infectious diseases are not well-controlled, underlining a critical need for new, more effective therapies. Pathogens and pathogen-infected host…”
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BIRC6 protein, an inhibitor of apoptosis: role in survival of human prostate cancer cells by Low, Christopher G, Luk, Iris S U, Lin, Dong, Fazli, Ladan, Yang, Kuo, Xu, Yong, Gleave, Martin, Gout, Peter W, Wang, Yuzhuo

“…BIRC6 is a member of the Inhibitors of Apoptosis Protein (IAP) family which is thought to protect a variety of cancer cells from apoptosis. The main objective…”
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Identification of novel therapeutic targets in microdissected clear cell ovarian cancers by Stany, Michael P, Vathipadiekal, Vinod, Ozbun, Laurent, Stone, Rebecca L, Mok, Samuel C, Xue, Hui, Kagami, Takashi, Wang, Yuwei, McAlpine, Jessica N, Bowtell, David, Gout, Peter W, Miller, Dianne M, Gilks, C Blake, Huntsman, David G, Ellard, Susan L, Wang, Yu-Zhuo, Vivas-Mejia, Pablo, Lopez-Berestein, Gabriel, Sood, Anil K, Birrer, Michael J

“…Clear cell ovarian cancer is an epithelial ovarian cancer histotype that is less responsive to chemotherapy and carries poorer prognosis than serous and…”
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Metabolic heterogeneity signature of primary treatment-naïve prostate cancer by Lin, Dong, Ettinger, Susan L, Qu, Sifeng, Xue, Hui, Nabavi, Noushin, Choi, Stephen Yiu Chuen, Bell, Robert H, Mo, Fan, Haegert, Anne M, Gout, Peter W, Fleshner, Neil, Gleave, Martin E, Pollak, Michael, Collins, Colin C, Wang, Yuzhuo

“…To avoid over- or under-treatment of primary prostate tumours, there is a critical need for molecular signatures to discriminate indolent from aggressive,…”
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Next generation patient-derived prostate cancer xenograft models by Lin, Dong, Xue, Hui, Wang, Yuwei, Wu, Rebecca, Watahiki, Akira, Dong, Xin, Cheng, Hongwei, Wyatt, Alexander W, Collins, Colin C, Gout, Peter W, Wang, Yuzhuo

“…There is a critical need for more effective therapeutic approaches for prostate cancer. Research in this area, however, has been seriously hampered by a lack…”
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Establishment in Severe Combined Immunodeficiency Mice of Subrenal Capsule Xenografts and Transplantable Tumor Lines from a Variety of Primary Human Lung Cancers: Potential Models for Studying Tumor Progression–Related Changes by Cutz, Jean-Claude, Guan, Jun, Bayani, Jane, Yoshimoto, Maisa, Xue, Hui, Sutcliffe, Margaret, English, John, Flint, Julia, LeRiche, Jean, Yee, John, Squire, Jeremy A, Gout, Peter W, Lam, Stephen, Wang, Yu-Zhuo

“…Purpose: Lung cancer is a biologically diverse disease and relevant models reflecting its diversity would facilitate the improvement of existing therapies…”
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Epithelial immune cell-like transition (EIT): A proposed transdifferentiation process underlying immune-suppressive activity of epithelial cancers by Choi, Stephen Yiu Chuen, Gout, Peter W., Collins, Colin C., Wang, Yuzhuo

“…The immune system plays a key role in eliminating cancer cells in the body. However, even in fully immune-competent bodies cancers can evade anti-tumor immune…”
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Prostate cancer metastasis-driving genes： hurdles and potential approaches in their identification by Chiang, Yan Ting, Gout, Peter W, Collins, Colin C, Wang, Yuzhuo

“…Metastatic prostate cancer is currently incurable. Metastasis is thoughtto result from changes in the expression of specific metastasis-driving genes in…”
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Sulfasalazine-induced cystine starvation: Potential use for prostate cancer therapy by Doxsee, Daniel W., Gout, Peter W., Kurita, Takeshi, Lo, Maisie, Buckley, Arthur R., Wang, Yuwei, Xue, Hui, Karp, Cristina M., Cutz, Jean-Claude, Cunha, Gerald R., Wang, Yu-Zhuo

“…BACKGROUND Certain cancers depend for growth on uptake of cystine/cysteine from their environment. Here we examined advanced human prostate cancer cell lines,…”
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The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities by Lewerenz, Jan, Hewett, Sandra J, Huang, Ying, Lambros, Maria, Gout, Peter W, Kalivas, Peter W, Massie, Ann, Smolders, Ilse, Methner, Axel, Pergande, Mathias, Smith, Sylvia B, Ganapathy, Vadivel, Maher, Pamela

“…The antiporter system x(c)(-) imports the amino acid cystine, the oxidized form of cysteine, into cells with a 1:1 counter-transport of glutamate. It is…”
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An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line by YUWEI WANG, HUI XUE, GOUT, Peter W, SQUIRE, Jeremy A, CUNHA, Gerald R, WANG, Yu-Zhuo, CUTZ, Jean-Claude, BAYANI, Jane, MAWJI, Nasrin R, CHEN, Wilfred G, GOETZ, Lester J, HAYWARD, Simon W, SADAR, Marianne D, GILKS, C. Blake

“…Metastasis is the major cause of prostate cancer deaths and there is a need for clinically relevant in vivo models allowing elucidation of molecular and…”
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