Search Results - "Gourdie, Trudi A"

DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard by Gourdie, Trudi A, Valu, Kisione K, Gravatt, G. Lance, Boritzki, Theodore J, Baguley, Bruce C, Wakelin, Laurence P. G, Wilson, William R, Woodgate, Paul D, Denny, William A

“…A series of DNA-targeted aniline mustards have been prepared, and their chemical reactivity and in vitro and in vivo cytotoxicity have been evaluated and…”
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DNA-directed alkylating ligands as potential antitumor agents: sequence specificity of alkylation by intercalating aniline mustards by Prakash, A. S, Denny, William A, Gourdie, Trudi A, Valu, Kisione K, Woodgate, Paul D, Wakelin, Laurence P. G

“…The sequence preferences for alkylation of a series of novel parasubstituted aniline mustards linked to the DNA-intercalating chromophore 9-aminoacridine by an…”
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DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain by Valu, Kisione K, Gourdie, Trudi A, Boritzki, Theodore J, Gravatt, G. Lance, Baguley, Bruce C, Wilson, William R, Wakelin, Laurence P. G, Woodgate, Paul D, Denny, William A

“…Four series of acridine-linked aniline mustards have been prepared and evaluated for in vitro cytotoxicity, in vivo antitumor activity, and DNA cross-linking…”
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Synthesis and evaluation of DNA-targeted spatially separated bis(aniline mustards) as potential alkylating agents with enhanced DNA cross-linking capability by Gourdie, Trudi A, Prakash, A. S, Wakelin, Laurence P. G, Woodgate, Paul D, Denny, William A

“…DNA-targeted separated bis-mustards were synthesized by attaching aniline mono-mustards at the 4- and 9-positions of the DNA-intercalating ligand…”
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'Petite' mutagenesis and mitotic crossing-over in yeast by DNA-targeted alkylating agents by Ferguson, L R, Turner, P M, Gourdie, T A, Valu, K K, Denny, W A

“…Although the biological properties (cytotoxicity, mutagenicity and carcinogenicity) of alkylating agents result from their bonding interactions with DNA, such…”
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