Search Results - "Gour, Naina"

IL-4 and IL-13 signaling in allergic airway disease by Gour, Naina, Wills-Karp, Marsha

“…Aberrant production of the prototypical type 2 cytokines, interleukin (IL)-4 and IL-13 has long been associated with the pathogenesis of allergic disorders…”
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A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain by Green, Dustin P., Limjunyawong, Nathachit, Gour, Naina, Pundir, Priyanka, Dong, Xinzhong

“…Mast cells can be found in close proximity to peripheral nerve endings where, upon activation, they release a broad range of pro-inflammatory cytokines and…”
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Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity by Smole, Ursula, Gour, Naina, Phelan, Jordan, Hofer, Gerhard, Köhler, Cordula, Kratzer, Bernhard, Tauber, Peter A., Xiao, Xiao, Yao, Nu, Dvorak, Jan, Caraballo, Luis, Puerta, Leonardo, Rosskopf, Sandra, Chakir, Jamila, Malle, Ernst, Lane, Andrew P., Pickl, Winfried F., Lajoie, Stephane, Wills-Karp, Marsha

“…The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that…”
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Epithelial Cell Regulation of Allergic Diseases by Gour, Naina, Lajoie, Stephane

“…Allergic diseases, which have escalated in prevalence in recent years, arise as a result of maladaptive immune responses to ubiquitous environmental stimuli…”
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C3a is required for ILC2 function in allergic airway inflammation by Gour, Naina, Smole, Ursula, Yong, Hwan-Mee, Lewkowich, Ian P., Yao, Nu, Singh, Anju, Gabrielson, Edward, Wills-Karp, Marsha, Lajoie, Stephane

“…Aberrant type 2 responses underlie the pathologies in allergic diseases like asthma, yet, our understanding of the mechanisms that drive them remains limited…”
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Eradication of Staphylococcus aureus Biofilm Infection by Persister Drug Combination by Yee, Rebecca, Yuan, Yuting, Tarff, Andreina, Brayton, Cory, Gour, Naina, Feng, Jie, Zhang, Ying

“…can cause a variety of infections, including persistent biofilm infections, which are difficult to eradicate with current antibiotic treatments. Here, we…”
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Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases by Gour, Naina, Lajoie, Stephane, Smole, Ursula, White, Marquitta, Hu, Donglei, Goddard, Pagé, Huntsman, Scott, Eng, Celeste, Mak, Angel, Oh, Sam, Kim, Jung-Hyun, Sharma, Annu, Plante, Sophie, Salem, Ikhlass Haj, Resch, Yvonne, Xiao, Xiao, Yao, Nu, Singh, Anju, Vrtala, Susanne, Chakir, Jamila, Burchard, Esteban G, Lane, Andrew P, Wills-Karp, Marsha

“…The key factors underlying the development of allergic diseases-the propensity for a minority of individuals to develop dysfunctional responses to harmless…”
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The MRGPR family of receptors in immunity by Gour, Naina, Dong, Xinzhong

“…The discovery of Mas-related G protein-coupled receptors (Mrgprs) has opened a compelling chapter in our understanding of immunity and sensory biology. This…”
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Identification and function of a C3 hiIL-33 +fibroblast population in the lungs by Atakkatan, Aishwarya, Gour, Naina, Magesh, Aishwarya, Yong, Hwan Mee, Lajoie, Stephane

“…Complement component C3 is known to be predominantly expressed by epithelial and immune cells, however, we have found that fibroblasts are a primary source of…”
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NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes by Singh, Anju, Daemen, Anneleen, Nickles, Dorothee, Jeon, Sang-Min, Foreman, Oded, Sudini, Kuladeep, Gnad, Florian, Lajoie, Stephane, Gour, Naina, Mitzner, Wayne, Chatterjee, Samit, Choi, Eun-Ji, Ravishankar, Buvana, Rappaport, Amy, Patil, Namrata, McCleland, Mark, Johnson, Leisa, Acquaah-Mensah, George, Gabrielson, Edward, Biswal, Shyam, Hatzivassiliou, Georgia

“…Stabilization of the transcription factor NRF2 through genomic alterations in and occurs in a quarter of patients with lung adenocarcinoma and a third of…”
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Suppression of type-2 mediated allergic diseases by dectin-1 by Gour, Naina, Lajoie, Stephane, Wills-Karp, Marsha

“…Allergic diseases, which have escalated in prevalence in recent years, arise as a result of maladaptive immune responses to ubiquitous environmental proteins…”
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Epigenetic regulation of epithelial dectin‐1 through an IL‐33‐STAT3 axis in allergic disease by Yong, Hwan Mee, Gour, Naina, Sharma, Deepika, Khalil, Syed Muaz, Lane, Andrew P., Lajoie, Stephane

“…Allergic diseases arise in susceptible individuals in part because of decrements in protective pathways. The mechanism by which these anti‐inflammatory…”
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Carbohydrates in dust mite allergen modulate Th2 immune responses (P6019) by Gour, Naina, Wills-Karp, Marsha

“…Asthma is a chronic inflammatory disease of the airways, driven by a Th2 immune response to allergens like house dust mite (HDM). While Th2 immune responses…”
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Identification of Persister Drug Combination Clinafloxacin + Cefuroxime + Gentamicin That Eradicates Persistent Pseudomonas aeruginosa Infection in a Murine Cystic Fibrosis Model by Yuan, Yuting, Yee, Rebecca, Gour, Naina, Dong, Xinzhong, Feng, Jie, Shi, Wanliang, Zhang, Ying

“…Pseudomonas aeruginosa can cause persistent infections, such as biofilm infections, in cystic fibrosis (CF) patients, which are difficult to cure due to…”
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Air Pollution Drives Macrophage Senescence through a Phagolysosome-15-Lipoxygenase Pathway by Thomas, Sarah A, Yong, Hwan Mee, Rule, Ana M, Gour, Naina, Lajoie, Stephane

“…Urban particulate matter (PM; uPM) poses significant health risks, particularly to the respiratory system. Fine particles, such as PM2.5, can penetrate deep…”
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Interleukin 13 (IL‐13) alters hypoxia‐associated genes and upregulates CD73 by Khalil, Syed Muaz, Bernstein, Isaac, Kulaga, Heather, Gour, Naina, Rowan, Nicholas, Lajoie, Stephane, Lane, Andrew P.

“…Background Interleukin 13 (IL‐13) is a pleiotropic cytokine that has been shown to be important in the pathogenesis of chronic rhinosinusitis with nasal polyps…”
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Identification of Persister Drug Combination Clinafloxacin + Cefuroxime + Gentamicin That Eradicates Persistent Pseudomonas aeruginosa Infection in a Murine Cystic Fibrosis Model by Yuan, Yuting, Yee, Rebecca, Gour, Naina, Dong, Xinzhong, Feng, Jie, Shi, Wanliang, Zhang, Ying

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Eradication of IStaphylococcus aureus/I Biofilm Infection by Persister Drug Combination by Yee, Rebecca, Yuan, Yuting, Tarff, Andreina, Brayton, Cory, Gour, Naina, Feng, Jie, Zhang, Ying

“…Staphylococcus aureus can cause a variety of infections, including persistent biofilm infections, which are difficult to eradicate with current antibiotic…”
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Unique pulmonary immunotoxicological effects of urban PM are not recapitulated solely by carbon black, diesel exhaust or coal fly ash by Gour, Naina, Sudini, Kuladeep, Khalil, Syed Muaz, Rule, Ana M., Lees, Peter, Gabrielson, Edward, Groopman, John D., Lajoie, Stephane, Singh, Anju

“…Exposure to particulate matter (PM) is increasing worldwide as a result of increased human activity, the rapid industrialization of developing countries, and…”
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Dectin-1 Is A Critical Negative Regulator of Allergic Asthma by Gour, Naina

“…Asthma is a chronic inflammatory disease of the airways, driven by an inappropriate Type-2 immune response to innocuous allergens in susceptible individuals…”
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