Search Results - "Gounis, Matthew J"

A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system by Alterman, Julia F., Godinho, Bruno M. D. C., Hassler, Matthew R., Ferguson, Chantal M., Echeverria, Dimas, Sapp, Ellen, Haraszti, Reka A., Coles, Andrew H., Conroy, Faith, Miller, Rachael, Roux, Loic, Yan, Paul, Knox, Emily G., Turanov, Anton A., King, Robert M., Gernoux, Gwladys, Mueller, Christian, Gray-Edwards, Heather L., Moser, Richard P., Bishop, Nina C., Jaber, Samer M., Gounis, Matthew J., Sena-Esteves, Miguel, Pai, Athma A., DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

“…Sustained silencing of gene expression throughout the brain using small interfering RNAs (siRNAs) has not been achieved. Here we describe an siRNA…”
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Modelling the impact of clot fragmentation on the microcirculation after thrombectomy by El-Bouri, Wahbi K, MacGowan, Andrew, Józsa, Tamás I, Gounis, Matthew J, Payne, Stephen J

“…Many ischaemic stroke patients who have a mechanical removal of their clot (thrombectomy) do not get reperfusion of tissue despite the thrombus being removed…”
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Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots by Fitzgerald, Seán, Wang, Shunli, Dai, Daying, Murphree, Jr, Dennis H, Pandit, Abhay, Douglas, Andrew, Rizvi, Asim, Kadirvel, Ramanathan, Gilvarry, Michael, McCarthy, Ray, Stritt, Manuel, Gounis, Matthew J, Brinjikji, Waleed, Kallmes, David F, Doyle, Karen M

“…Our aim was to assess the utility of a novel machine learning software (Orbit Image Analysis) in the histological quantification of acute ischemic stroke (AIS)…”
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A neurovascular high-frequency optical coherence tomography system enables in situ cerebrovascular volumetric microscopy by Ughi, Giovanni J., Marosfoi, Miklos G., King, Robert M., Caroff, Jildaz, Peterson, Lindsy M., Duncan, Benjamin H., Langan, Erin T., Collins, Amanda, Leporati, Anita, Rousselle, Serge, Lopes, Demetrius K., Gounis, Matthew J., Puri, Ajit S.

“…Intravascular imaging has emerged as a valuable tool for the treatment of coronary and peripheral artery disease; however, no solution is available for safe…”
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ARTS (Aspiration–Retriever Technique for Stroke): Initial clinical experience by Massari, Francesco, Henninger, Nils, Lozano, Juan Diego, Patel, Anand, Kuhn, Anna Luisa, Howk, Mary, Perras, Mary, Brooks, Christopher, Gounis, Matthew J, Kan, Peter, Wakhloo, Ajay K, Puri, Ajit S

“…Background A new generation of highly navigable large-bore aspiration catheters and retriever devices for intracranial mechanical thrombectomy has markedly…”
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Role of Balloon Guide Catheter in Modern Endovascular Thrombectomy by Chueh, Ju-Yu, Kang, Dong-Hun, Kim, Byung Moon, Gounis, Matthew J

“…Proximal flow control achieved with a balloon guide catheter (BGC) during endovascular treatment of acute ischemic stroke is reviewed in this article. In…”
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Cumulative effect of simvastatin, L-arginine, and tetrahydrobiopterin on cerebral blood flow and cognitive function in Alzheimer's disease by Degrush, Elizabeth, Shazeeb, Mohammed Salman, Drachman, David, Vardar, Zeynep, Lindsay, Clifford, Gounis, Matthew J, Henninger, Nils

“…Vascular disease is a known risk factor for Alzheimer's disease (AD). Endothelial dysfunction has been linked to reduced cerebral blood flow. Endothelial…”
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X‑ray Attenuating Vesicles with Neutrophil Extracellular Trap (NET) Specificity: Synthesis and Testing in a Model System by Epshtein, Mark, Gounis, Matthew J., Bogdanov, Alexei A.

“…X-ray attenuating contrast agents for imaging thrombi directly during endovascular thrombectomy (EVT) are urgently needed for shortening the wait time for…”
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Safety, efficacy, and short-term follow-up of the use of Pipeline™ Embolization Device in small (<2.5mm) cerebral vessels for aneurysm treatment: single institution experience by Puri, Ajit S., Massari, Francesco, Asai, Takumi, Marosfoi, Miklos, Kan, Peter, Hou, Samuel Y., Howk, Mary, Perras, Mary, Brooks, Christopher, Clarencon, Frederic, Gounis, Matthew J., Wakhloo, Ajay K.

“…Introduction Flow diversion is being increasingly used to treat cerebral aneurysms. We present our experience using these stents to treat aneurysms distal to…”
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Diagnostic Magnetic Resonance Imaging of Atherosclerosis in Apolipoprotein E Knockout Mouse Model Using Macrophage-Targeted Gadolinium-Containing Synthetic Lipopeptide Nanoparticles by Shen, Zu T, Zheng, Shaokuan, Gounis, Matthew J, Sigalov, Alexander B

“…Cardiovascular disease is the leading cause of death in Western cultures. The vast majority of cardiovascular events, including stroke and myocardial…”
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Chemical exchange saturation transfer effect in blood by Zheng, Shaokuan, van der Bom, Imramsjah M. J., Zu, Zhongliang, Lin, Guoxing, Zhao, Yansong, Gounis, Matthew J.

“…Purpose In this report, the feasibility of using blood as an agent for Chemical Exchange Saturation Transfer (CEST) effect is investigated. Methods The CEST…”
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Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT by Fitzgerald, Sean T, Wang, Shunli, Dai, Daying, Douglas, Andrew, Kadirvel, Ramanathan, Gounis, Matthew J, Chueh, Juyu, Puri, Ajit S, Layton, Kennith F, Thacker, Ike C, Hanel, Ricardo A, Sauvageau, Eric, Aghaebrahim, Amin, Almekhlafi, Mohammed A, Demchuk, Andrew M, Nogueira, Raul G, Pereira, Vitor M, Kvamme, Peter, Kayan, Yasha, Delgado Almandoz, Josser E, Yoo, Albert J, Kallmes, David F, Doyle, Karen M, Brinjikji, Waleed

“…Current studies on clot characterization in acute ischemic stroke focus on fibrin and red blood cell composition. Few studies have examined platelet…”
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Awake intracerebroventricular delivery and safety assessment of oligonucleotides in a large animal model by Benatti, Hector Ribeiro, Prestigiacomo, Rachel D., Taghian, Toloo, Miller, Rachael, King, Robert, Gounis, Matthew J., Celik, Ugur, Bertrand, Stephanie, Tuominen, Susan, Bierfeldt, Lindsey, Parsley, Elizabeth, Gallagher, Jillian, Hall, Erin F., McElroy, Abigail W., Sena-Esteves, Miguel, Khvorova, Anastasia, Aronin, Neil, Gray-Edwards, Heather L.

“…Oligonucleotide therapeutics offer great promise in the treatment of previously untreatable neurodegenerative disorders; however, there are some challenges to…”
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Impact of histological clot composition on preprocedure imaging and mechanical thrombectomy by Johnson, Jeremiah, Srivatsan, Aditya, Chueh, Juyu, Arslanian, Rose, Gounis, Matthew, Puri, Ajit, Srinivasan, Visish, Chen, Stephen, Burkhardt, Jan-Karl, Kan, Peter

“…INTRODUCTION: We studied the relationship of acute ischemic stroke (AIS) large-vessel occlusion clot composition with vessel recanalization and preprocedure…”
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Biophysical targeting of high‐risk cerebral aneurysms by Epshtein, Mark, Levi, Moran, Kraitem, Afif M., Zidan, Hikaia, King, Robert M., Gawaz, Meinrad, Gounis, Matthew J., Korin, Netanel

“…Localized delivery of diagnostic/therapeutic agents to cerebral aneurysms, lesions in brain arteries, may offer a new treatment paradigm. Since aneurysm…”
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Grading of Regional Apposition after Flow-Diverter Treatment (GRAFT): a comparative evaluation of VasoCT and intravascular OCT by van der Marel, Kajo, Gounis, Matthew J, Weaver, John P, de Korte, Antonius M, King, Robert M, Arends, Jennifer M, Brooks, Olivia W, Wakhloo, Ajay K, Puri, Ajit S

“…Poor vessel wall apposition of flow diverter (FD) stents poses risks for stroke-related complications when treating intracranial aneurysms, necessitating…”
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Real-time MR tracking of AAV gene therapy with βgal-responsive MR probe in a murine model of GM1-gangliosidosis by Taghian, Toloo, Batista, Ana Rita, Kamper, Sarah, Caldwell, Michael, Lilley, Laura, Li, Hao, Rodriguez, Paola, Mesa, Katerina, Zheng, Shaokuan, King, Robert M., Gounis, Matthew J., Todeasa, Sophia, Maguire, Anne, Martin, Douglas R., Sena-Esteves, Miguel, Meade, Thomas J., Gray-Edwards, Heather L.

“…Transformative results of adeno-associated virus (AAV) gene therapy in patients with spinal muscular atrophy and Leber’s congenital amaurosis led to approval…”
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Endovascular treatment of tandem vascular occlusions in acute ischemic stroke by Puri, Ajit S, Kühn, Anna L, Kwon, Hyon-Jo, Khan, Muhib, Hou, Samuel Y, Lin, Eugene, Chueh, Juyu, van der Bom, Imramsjah M J, Dabus, Guilherme, Linfante, Italo, Gounis, Matthew J, Wakhloo, Ajay K

“…Tandem vascular occlusions are an important cause of acute ischemic stroke (AIS) and present unique treatment challenges. We report our experience of managing…”
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Semi-jailing technique for coil embolization of complex, wide-necked intracranial aneurysms by Hong, Bo, Patel, Neil V, Gounis, Matthew J, DeLeo, 3rd, Michael J, Linfante, Italo, Wojak, Joan C, Wakhloo, Ajay K

“…Stent-assisted coiling of intracranial aneurysms is performed by placing a microcatheter through a stent's interstices or jailing the microcatheter between the…”
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Novel Distal Emboli Protection Technology: The EmboTrap by Chueh, Ju-Yu, Marosfoi, Miklos G., Brooks, Olivia W., King, Robert M., Puri, Ajit S., Gounis, Matthew J.

“…Background: Over the course of the thrombectomy procedure, clot fragments may become dislodged and lead to downstream emboli due to manipulation of an…”
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