Search Results - "Goumon, Y."

Endogenous morphine and its metabolites in mammals: History, synthesis, localization and perspectives by Laux-Biehlmann, A, Mouheiche, J, Vérièpe, J, Goumon, Y

“…Highlights ► Endogenous morphine and glucuronides are synthesized by mammalian cells from dopamine. ► Endogenous morphine-derived alkaloids are present in both…”
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Etifoxine stimulates allopregnanolone synthesis in the spinal cord to produce analgesia in experimental mononeuropathy by Aouad, M., Petit-Demoulière, N., Goumon, Y., Poisbeau, P.

“…Background Pathological pain states are often associated with neuronal hyperexcitability in the spinal cord. Reducing this excitability could theoretically be…”
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Innate immunity: involvement of new neuropeptides by Metz-Boutigue, M.H, Kieffer, A.E, Goumon, Y, Aunis, D

“…Secretory granules of chromaffin cells from the adrenal medulla store catecholamines and a variety of peptides that are secreted in the extracellular medium…”
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Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: cyp2d6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling by Zhu, Wei, Mantione, Kirk J, Shen, Lihua, Cadet, Patrick, Esch, Tobias, Goumon, Yannick, Bianchi, Enrica, Sonetti, Dario, Stefano, George B

“…The ability of animals to make morphine has been in question for the last 30 years. Studies have demonstrated that animals do contain morphine precursors and…”
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Pain, immunity, opiate and opioid compounds and health by Stefano, George B, Fricchione, Gregory, Goumon, Yannick, Esch, Tobias

“…We surmise that opioid peptides, i.e., methionine enkephalin, first arose during evolution as modulators of cellular immune function given their immune actions…”
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The Hippocampal Cholinergic Neurostimulating Peptide, the N-terminal Fragment of the Secreted Phosphatidylethanolamine-binding Protein, Possesses a New Biological Activity on Cardiac Physiology by Goumon, Yannick, Angelone, Tommaso, Schoentgen, Françoise, Chasserot-Golaz, Sylvette, Almas, Bjorg, Fukami, Miriam M., Langley, Keith, Welters, Ingeborg D., Tota, Bruno, Aunis, Dominique, Metz-Boutigue, Marie-Hélène

“…Phosphatidylethanolamine-binding protein (PEBP), alternatively named Raf-1 kinase inhibitor protein, is the precursor of the hippocampal cholinergic…”
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Antimicrobial chromogranins and proenkephalin-A-derived peptides: Antibacterial and antifungal activities of chromogranins and proenkephalin-A-derived peptides by Metz-Boutigue, M H, Goumon, Y, Strub, J M, Lugardon, K, Aunis, D

“…The secretory granules from adrenal medullary chromaffin cells contain a complex mixture of low-molecular mass constituents such as catecholamines, ascorbate,…”
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Cardiac cytoskeleton is modulated by human recombinant Vasostatin 1 by Angelone, T, Mazza, R, Mannarino, C, Filice, E, Barbieri, S, Goumon, Y, Zummo, G, Metz-Boutigue, M.-H, Tota, B

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A new human chromogranin A (CgA) immunoradiometric assay involving monoclonal antibodies raised against the unprocessed central domain (145-245) by DEGORCE, F, GOUMON, Y, JACQUEMART, L, VIDAUD, C, BELLANGER, L, PONS-ANICET, D, SEGUIN, P, METZ-BOUTIGUE, M, AUNIS, D

“…Chromogranin A (CgA), a major protein of chromaffin granules, has been described as a potential marker for neuroendocrine tumours. Because of an extensive…”
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Morphine inhibits AP-1 activity and CD14 expression in leukocytes by a nitric oxide and opioid receptor-dependent mechanism by Welters, I. D., Menzebach, A., Goumon, Y., Langefeld, T. W., Harbach, H., Mühling, J., Cadet, P., Stefano, G. B.

“…BACKGROUND:Activator protein 1 is a transcription factor involved in the regulation of proinflammatory mediators. Activation of phagocytes by…”
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Presence of endogenous morphine and morphine 6 glucuronide in human heart tissue by Zhu, W, Bilfinger, T V, Baggerman, G, Goumon, Y, Stefano, G B

“…Human atria contain the opiate alkaloids morphine and morphine 6 glucuronide as determined by high performance liquid chromatography coupled to electrochemical…”
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Characterization of a morphine-like molecule in secretory granules of chromaffin cells by Goumon, Yannick, Strub, Jean-Marc, Stefano, George B, Van Dorsselaer, Alain, Aunis, Dominique, Metz-Boutigue, Marie-Hélène

“…Morphine and morphine-like molecules were identified in numerous mammalian tissues. In particularly, morphine was present in adrenal gland and in PC-12 cells,…”
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Invertebrate opiate immune and neural signaling by Stefano, George B, Cadet, Patrick, Rialas, Christos M, Mantione, Kirk, Casares, Federico, Goumon, Yannick, Zhu, Wei

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Endogenous morphine is produced in response to cardiopulmonary bypass in neonatal pigs by Brix-Christensen, V., Goumon, Y., TØnnesen, E., Chew, M., Bilfinger, T., Stefano, G. B.

“…Background: Cardiopulmonary bypass (CPB) is associated with a systemic inflammatory response. Endogenous morphine production has previously been demonstrated…”
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A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline by Kremer, Mélanie, Yalcin, Ipek, Goumon, Yannick, Wurtz, Xavier, Nexon, Laurent, Daniel, Dorothée, Megat, Salim, Ceredig, Rhian A, Ernst, Carl, Turecki, Gustavo, Chavant, Virginie, Théroux, Jean-François, Lacaud, Adrien, Joganah, Lauriane-Elisabeth, Lelievre, Vincent, Massotte, Dominique, Lutz, Pierre-Eric, Gilsbach, Ralf, Salvat, Eric, Barrot, Michel

“…In addition to treating depression, antidepressant drugs are also a first-line treatment for neuropathic pain, which is pain secondary to lesion or pathology…”
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Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide by Roeckel, Laurie-Anne, Utard, Valérie, Reiss, David, Mouheiche, Jinane, Maurin, Hervé, Robé, Anne, Audouard, Emilie, Wood, John N., Goumon, Yannick, Simonin, Frédéric, Gaveriaux-Ruff, Claire

“…Opiates are potent analgesics but their clinical use is limited by side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). The…”
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Implications physiologiques potentielles de la morphine endogène by Goumon, Y., Laux, A., Muller, A. H.

“…Résumé Depuis le début des années 1980, la morphine endogène dont la structure est identique à la morphine produite par le pavot a été caractérisée dans de…”
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Morphine decreases the pro-angiogenic interaction between breast cancer cells and macrophages in vitro by Khabbazi, Samira, Nassar, Zeyad D., Goumon, Yannick, Parat, Marie-Odile

“…Interactions between the various cell types that constitute a solid tumour are essential to the biology of the tumour. We evaluated the effect of morphine on…”
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Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils by Glattard, Elise, Welters, Ingeborg D, Lavaux, Thomas, Muller, Arnaud H, Laux, Alexis, Zhang, Dan, Schmidt, Alexander R, Delalande, François, Laventie, Benoît-Joseph, Dirrig-Grosch, Sylvie, Colin, Didier A, Van Dorsselaer, Alain, Aunis, Dominique, Metz-Boutigue, Marie-Hélène, Schneider, Francis, Goumon, Yannick

“…Mammalian cells synthesize morphine and the respective biosynthetic pathway has been elucidated. Human neutrophils release this alkaloid into the media after…”
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Morphine suppresses complement receptor expression, phagocytosis, and respiratory burst in neutrophils by a nitric oxide and μ3 opiate receptor-dependent mechanism by Welters, I.D., Menzebach, A., Goumon, Y., Langefeld, T.W., Teschemacher, H., Hempelmann, G., Stefano, G.B.

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