Search Results - "Goumans, M J"

The morphological and molecular mechanisms of epithelial/endothelial-to-mesenchymal transition and its involvement in atherosclerosis by Wesseling, M., Sakkers, T.R., de Jager, S.C.A., Pasterkamp, G., Goumans, M.J.

“…Cell transdifferentiation occurs during cardiovascular development or remodeling either as a pathologic feature in the progression of disease or as a response…”
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Expression of TGFβ-family signalling components in ageing cartilage: Age-related loss of TGFβ and BMP receptors by van Caam, Arjan, Madej, Wojciech, Thijsen, Eva, Garcia de Vinuesa, Amaya, van den Berg, Wim, Goumans, Marie-José, ten Dijke, Peter, Blaney Davidson, Esmeralda, van der Kraan, Peter, Ph.D

“…Summary Objective Ageing is the main risk factor for osteoarthritis (OA).We investigated if expression of transforming growth factor β (TGFβ)-family…”
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The high affinity ALK1-ligand BMP9 induces a hypertrophy-like state in chondrocytes that is antagonized by TGFβ1 by van Caam, A, Blaney Davidson, E, Garcia de Vinuesa, A, van Geffen, E, van den Berg, W, Goumans, M.-J, ten Dijke, P, van der Kraan, P

“…Summary Objective In osteoarthritic cartilage, expression of the receptor ALK1 correlates with markers of deleterious chondrocyte hypertrophy. Recently, bone…”
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Preservation of human heart valves for replacement in children with heart valve disease: past, present and future by Peters, M. C., Kruithof, B. P. T., Bouten, C. V. C., Voets, I. K., van den Bogaerdt, A., Goumans, M. J., van Wijk, A.

“…Valvular heart disease affects 30% of the new-borns with congenital heart disease. Valve replacement of semilunar valves by mechanical, bioprosthetic or donor…”
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Balancing the activation state of the endothelium via two distinct TGF-β type I receptors by Goumans, Marie-José, Valdimarsdottir, Gudrun, Itoh, Susumu, Rosendahl, Alexander, Sideras, Paschalis, ten Dijke, Peter

“…The generation of mice lacking specific components of the transforming growth factor‐β (TGF‐β) signal tranduction pathway shows that TGF‐β is a key player in…”
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Development of a Blueprint for Integrated Care for Vulnerable Pregnant Women by Harmsen van der Vliet-Torij, H. W., Venekamp, A. A., van Heijningen-Tousain, H. J. M., Wingelaar-Loomans, E., Scheele, J., de Graaf, J. P., Lambregtse-van den Berg, M. P., Steegers, E. A. P., Goumans, M. J. B. M.

“…Purpose There has been increasing awareness of perinatal health and organisation of maternal and child health care in the Netherlands as a result of poor…”
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Generation of Fibrodysplasia ossificans progressiva and control integration free iPSC lines from periodontal ligament fibroblasts by Sanchez-Duffhues, G., Mikkers, H., de Jong, D., Szuhai, K., de Vries, T.J., Freund, C., Bravenboer, N., van Es, R.J.J., Netelenbos, J.C., Goumans, M.-.J., Eekhoff, E.M.W., ten Dijke, P.

“…Fibrodysplasia ossificans progressiva (FOP) is a very rare devastating heterotopic ossification disorder, classically caused by a heterozygous single point…”
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LIM-only protein FHL2 attenuates inflammation in vascular smooth muscle cells through inhibition of the NFκB pathway by van de Pol, V., Vos, M., DeRuiter, M.C., Goumans, M.J., de Vries, C.J.M., Kurakula, K.

“…Despite the advent of new-generation drug-eluting stents, in-stent restenosis remains a significant problem in patients with coronary artery disease. In- stent…”
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Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels by de Vries, M. R., Parma, L., Peters, H. A. B., Schepers, A., Hamming, J. F., Jukema, J. W., Goumans, M. J. T. H., Guo, L., Finn, A. V., Virmani, R., Ozaki, C. K., Quax, P. H. A.

“…Background Plaque angiogenesis is associated with atherosclerotic lesion growth, plaque instability and negative clinical outcome. Plaque angiogenesis is a…”
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BMP signaling components are expressed in human fracture callus by Kloen, P, Di Paola, M, Borens, O, Richmond, J, Perino, G, Helfet, D.L, Goumans, M.J

“…Of the various growth factors involved in the healing response after a fracture, bone morphogenetic proteins (BMPs) are emerging as key modulators. BMPs exert…”
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Progenitor cells isolated from the human heart: a potential cell source for regenerative therapy by van Vliet, P., Roccio, M., Smits, A. M., van Oorschot, A. A. M., Metz, C. H. G., van Veen, T. A. B., Sluijter, J. P. G., Doevendans, P. A., Goumans, M-J.

“…In recent years, resident cardiac progenitor cells have been identified in, and isolated from the rodent heart. These cells show the potential to form…”
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Molecular mechanisms and targets of right ventricular fibrosis in pulmonary hypertension by Bekedam, F.T., Goumans, M.J., Bogaard, H.J., de Man, F.S., Llucià-Valldeperas, A.

“…Right ventricular fibrosis is a stress response, predominantly mediated by cardiac fibroblasts. This cell population is sensitive to increased levels of…”
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Transforming growth factor β signal transduction by Dennler, Sylviane, Goumans, Marie‐José, ten Dijke, Peter

“…Transforming growth factor beta1 (TGF‐β1) is the prototypic member of a large family of structurally related pleiotropic‐secreted cytokines that play a pivotal…”
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Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins by Feijen, A, Goumans, M J, van den Eijnden-van Raaij, A J

“…Using in situ hybridization we have studied the localization of the messenger RNAs encoding the inhibin/activin subunits (alpha, beta A, beta B), the…”
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Cardiac Progenitor-Cell Derived Exosomes as Cell-Free Therapeutic for Cardiac Repair by Mol, E A, Goumans, M J, Sluijter, J P G

“…Cardiac progenitor cells (CPCs) have emerged as potential therapy to improve cardiac repair and prevent damage in cardiac diseases. CPCs are a promising cell…”
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Knockout and knockin of the beta 1 exon D define distinct roles for integrin splice variants in heart function and embryonic development by Baudoin, C., Goumans, M.-J., Mummery, C., Sonnenberg, A.

“…The beta 1D integrin is a recently characterized isoform of the beta 1 subunit that is specifically expressed in heart and skeletal muscle. In this study we…”
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Young at heart. An update on cardiac regeneration by Smits, A M, Ramkisoensing, A A, Atsma, D E, Goumans, M-J

“…Cardiovascular disease remains one of the most important causes of mortality. Over the past decades important advances have been made in prevention and…”
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Defining vulnerability in European pregnant women, a Delphi study by Scheele, J., Harmsen van der Vliet–Torij, H.W., Wingelaar-Loomans, E.M., Goumans, M.J.B.M.

“…Vulnerability among pregnant women is an important and complex theme in the everyday practice of midwives. Exchanging knowledge and best practices about…”
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Tasks and responsibilities of clinical midwives in Dutch hospitals by Harmsen van der Vliet‐Torij, Hanneke W., Heijningen‐Tousain, Heidi J. M., Wingelaar‐Loomans, Eva, Engeltjes, Bernice, Steegers, Eric A. P., Goumans, Marleen J. B. M., Posthumus, Anke G.

“…Background The number of Dutch clinical midwives has increased substantially over the last 20 years, but their tasks, responsibilities, and formal positions…”
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Interrogating TGF-β Function and Regulation in Endothelial Cells by Maring, J A, van Meeteren, L A, Goumans, M J, Ten Dijke, Peter

“…Transforming growth factor-β (TGF-β) is a multifunctional cytokine with important roles in embryogenesis and maintaining tissue homeostasis during adult life…”
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