Search Results - "Goulielmos, G"
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Regional european genetic ancestry predicts type I interferon level and risk of severe viral infection
Published in QJM : An International Journal of Medicine (2024)“…Viral infection outcomes vary widely between individuals, ranging from mild symptoms to severe organ failure and death, and it is clear that host genetic…”
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The Effect of RFC G80A Polymorphism in Cretan children with acute lymphoblastic leukemia and its interaction with MTHFR C677T and A1298C polymorphisms
Published in International journal of laboratory hematology (01-08-2014)“…Summary Introduction The association between the risk of acute lymphoblastic leukemia (ALL) in children and enzymes involved in the folate metabolism has been…”
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Investigation of the genetic overlap between rheumatoid arthritis and psoriatic arthritis in a Greek population
Published in Scandinavian journal of rheumatology (04-05-2017)“…Objectives: Several rheumatoid arthritis (RA) susceptibility loci have also been found to be associated with psoriatic arthritis (PsA), demonstrating that…”
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Gene expression analysis in RA: towards personalized medicine
Published in The pharmacogenomics journal (01-04-2014)“…Gene expression has recently been at the forefront of advance in personalized medicine, notably in the field of cancer and transplantation, providing a…”
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Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers
Published in Annals of the rheumatic diseases (01-08-2010)“…Genetic factors have a substantial role in determining development of rheumatoid arthritis (RA), and are likely to account for 50-60% of disease…”
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Association of IRF5 polymorphisms with increased risk for systemic lupus erythematosus in population of Crete, a southern-eastern European Greek island
Published in Gene (30-04-2017)“…Interferon regulatory factor 5 (IRF5) regulates type I interferon (IFN)-responsive genes, and has been one of the most consistently associated genes with…”
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PB1755: CASPASE 8, CASPASE 10 AND FAS GENE POLYMORPHISMS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
Published in HemaSphere (23-06-2022)Get full text
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Inflammasomes and rheumatic diseases: evolving concepts
Published in Annals of the rheumatic diseases (01-10-2008)“…The realisation that the production of inflammatory cytokines in inflammatory rheumatic diseases may be induced by non-infectious endogenous signals has…”
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Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis
Published in Genes and immunity (01-12-2013)“…Alleles of interferon (IFN) regulatory factor 8 (IRF8) are associated with susceptibility to both systemic lupus erythematosus (SLE) and multiple sclerosis…”
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Association of juvenile idiopathic arthritis with PTPN22 rs2476601 is specific to females in a Greek population
Published in Pediatric rheumatology online journal (23-04-2016)“…Juvenile idiopathic arthritis (JIA) is an autoimmune disease characterized by persistent chronic arthritis. Disease risk is believed to be influenced by both…”
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Association of placenta previa with a history of previous Cesarian deliveries and indications for a possible role of a genetic component
Published in Balkan journal of medical genetics (29-12-2017)“…A prior Cesaria section (C-section) is an important risk factor that leads to endometrial damage and abnormal implantation of the placenta. Our retrospective…”
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Association of the PTPN22 R620W polymorphism with increased risk for SLE in the genetically homogeneous population of Crete
Published in Lupus (01-04-2011)“…Autoimmune diseases affect approximately 5% of the population, but much work remains to define the genetic risk factors and pathogenic mechanisms underlying…”
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Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis
Published in Clinical and experimental immunology (01-07-2013)“…Summary Rodent models for arthritis implicate a role for complement in disease development and progression. In humans, complement deposition has been observed…”
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Investigation of juvenile idiopathic arthritis susceptibility loci: Results from a Greek population
Published in Human immunology (01-09-2013)“…Abstract The strategy of studying the putative role of RA susceptibility genetic factors in the development of juvenile idiopathic arthritis (JIA), an…”
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Familial Mediterranean Fever in Crete: a genetic and structural biological approach in a population of 'intermediate risk'
Published in Clinical genetics (01-02-2008)“…Familial Mediterranean Fever (FMF) is an autosomal, recessively inherited disease, characterized by recurrent and short attacks of fever with serosal…”
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Polymorphisms of genes related to endothelial cells are associated with primary biliary cirrhosis patients of Cretan origin
Published in Human immunology (01-08-2012)“…Abstract Background Primary biliary cirrhosis (PBC) is an organ specific autoimmune disease of still unidentified genetic etiology. We have shown that…”
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Association of the nitric oxide synthase (eNOS) gene polymorphism with increased risk for both lupus glomerulonephritis and rheumatoid arthritis in a single genetically homogeneous population
Published in Lupus (01-01-2007)“…Nitric oxide (NO), a short-lived gaseous free radical, synthesized from L-arginine by NO synthases (NOS), is a potent mediator of biologic responses involved…”
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Differential expression of miR-4520a is associated with gain of function mutations in Familial Mediterranean Fever (FMF)
Published in Pediatric rheumatology online journal (28-09-2015)Get full text
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Mutational analysis of the PRYSPRY domain of pyrin and implications for familial mediterranean fever (FMF)
Published in Biochemical and biophysical research communications (14-07-2006)“…Familial Mediterranean fever (FMF) is an autosomal, recessively inherited disease, characterized by recurrent fever and serositis that affects mainly patients…”
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Intron 4 polymorphism of the endothelial nitric oxide synthase eNOS gene and early microangiopathy in type 1 diabetes
Published in International journal of immunogenetics (01-06-2009)“…Summary Nitric oxide (NO) is an endogenous vasodilator involved in inflammatory and autoimmune response, and in the pathophysiology of diabetic vascular…”
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