Search Results - "Goulding, W."

A Single Mutation in the Mycobacterium tuberculosis Heme-Degrading Protein, MhuD, Results in Different Products by Chao, Alex, Goulding, Celia W

“…Mycobacterium tuberculosis heme-degrading protein MhuD degrades heme to mycobilin isomers and iron, while its closest homologues from Staphylococcus aureus,…”
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Significant Acidification in Major Chinese Croplands by Guo, J.H, Liu, X.J, Zhang, Y, Shen, J.L, Han, W.X, Zhang, W.F, Christie, P, Goulding, K.W.T, Vitousek, P.M, Zhang, F.S

“…Soil acidification is a major problem in soils of intensive Chinese agricultural systems. We used two nationwide surveys, paired comparisons in numerous…”
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Soil resilience and recovery: rapid community responses to management changes by Hirsch, Penny R., Jhurreea, Deveraj, Williams, Jennifer K., Murray, Philip J., Scott, Tony, Misselbrook, Tom H., Goulding, Keith W. T., Clark, Ian M.

“…Background and aims: Soil degradation is a major global problem; to investigate the potential for recovery of soil biota and associated key functions, soils…”
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Soil carbon sequestration to mitigate climate change: a critical re-examination to identify the true and the false by Powlson, D.S, Whitmore, A.P, Goulding, K.W.T

“…The term ‘carbon sequestration' is commonly used to describe any increase in soil organic carbon (SOC) content caused by a change in land management, with the…”
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An optimized chemical-genetic method for cell-specific metabolic labeling of RNA by Nainar, Sarah, Cuthbert, Bonnie J., Lim, Nathan M., England, Whitney E., Ke, Ke, Sophal, Kanika, Quechol, Robert, Mobley, David L., Goulding, Celia W., Spitale, Robert C.

“…Tissues and organs are composed of diverse cell types, which poses a major challenge for cell-type-specific profiling of gene expression. Current metabolic…”
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Grassland biodiversity bounces back from long-term nitrogen addition by Storkey, J., Macdonald, A. J., Poulton, P. R., Scott, T., Köhler, I. H., Schnyder, H., Goulding, K. W. T., Crawley, M. J.

“…Data from the long-running Park Grass Experiment is used to show that grassland biodiversity is recovering since UK atmospheric nitrogen levels started to…”
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Contact-Dependent Growth Inhibition (CDI) and CdiB/CdiA Two-Partner Secretion Proteins by Willett, Julia L.E., Ruhe, Zachary C., Goulding, Celia W., Low, David A., Hayes, Christopher S.

“…Bacteria have developed several strategies to communicate and compete with one another in complex environments. One important mechanism of inter-bacterial…”
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Advanced glycation end-product crosslinking activates a type VI secretion system phospholipase effector protein by Jensen, Steven J., Cuthbert, Bonnie J., Garza-Sánchez, Fernando, Helou, Colette C., de Miranda, Rodger, Goulding, Celia W., Hayes, Christopher S.

“…Advanced glycation end-products (AGE) are a pervasive form of protein damage implicated in the pathogenesis of neurodegenerative disease, atherosclerosis and…”
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A comparison of two colorimetric assays, based upon Lowry and Bradford techniques, to estimate total protein in soil extracts by Redmile-Gordon, M.A., Armenise, E., White, R.P., Hirsch, P.R., Goulding, K.W.T.

“…Soil extracts usually contain large quantities of dissolved humified organic material, typically reflected by high polyphenolic content. Since polyphenols…”
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Heme Degradation by Staphylococcus aureus IsdG and IsdI Liberates Formaldehyde Rather Than Carbon Monoxide by Matsui, Toshitaka, Nambu, Shusuke, Ono, Yukari, Goulding, Celia W, Tsumoto, Kouhei, Ikeda-Saito, Masao

“…IsdG and IsdI from Staphylococcus aureus are novel heme-degrading enzymes containing unusually nonplanar (ruffled) heme. While canonical heme-degrading…”
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Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins by Gucinski, Grant C., Michalska, Karolina, Garza-Sánchez, Fernando, Eschenfeldt, William H., Stols, Lucy, Nguyen, Josephine Y., Goulding, Celia W., Joachimiak, Andrzej, Hayes, Christopher S.

“…Contact-dependent growth inhibition (CDI) is a form of interbacterial competition mediated by CdiB-CdiA two-partner secretion systems. CdiA effector proteins…”
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Unique coupling of mono- and dioxygenase chemistries in a single active site promotes heme degradation by Matsui, Toshitaka, Nambu, Shusuke, Goulding, Celia W., Takahashi, Satoshi, Fujii, Hiroshi, Ikeda-Saito, Masao

“…Bacterial pathogens must acquire host iron for survival and colonization. Because free iron is restricted in the host, numerous pathogens have evolved to…”
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Discovery and characterization of a unique mycobacterial heme acquisition system by Tullius, Michael V, Harmston, Christine A, Owens, Cedric P, Chim, Nicholas, Morse, Robert P, McMath, Lisa M, Iniguez, Angelina, Kimmey, Jacqueline M, Sawaya, Michael R, Whitelegge, Julian P, Horwitz, Marcus A, Goulding, Celia W

“…Mycobacterium tuberculosis must import iron from its host for survival, and its siderophore-dependent iron acquisition pathways are well established. Here we…”
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Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis by Borah, Khushboo, Mendum, Tom A, Hawkins, Nathaniel D, Ward, Jane L, Beale, Michael H, Larrouy‐Maumus, Gerald, Bhatt, Apoorva, Moulin, Martine, Haertlein, Michael, Strohmeier, Gernot, Pichler, Harald, Forsyth, V Trevor, Noack, Stephan, Goulding, Celia W, McFadden, Johnjoe, Beste, Dany J V

“…The co‐catabolism of multiple host‐derived carbon substrates is required by Mycobacterium tuberculosis (Mtb) to successfully sustain a tuberculosis infection…”
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The Mycobacterium tuberculosis Secreted Protein Rv0203 Transfers Heme to Membrane Proteins MmpL3 and MmpL11 by Owens, Cedric P., Chim, Nicholas, Graves, Amanda B., Harmston, Christine A., Iniguez, Angelina, Contreras, Heidi, Liptak, Matthew D., Goulding, Celia W.

“…Mycobacterium tuberculosis is the causative agent of tuberculosis, which is becoming an increasingly global public health problem due to the rise of…”
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Unraveling the essential role of CysK in CDI toxin activation by Johnson, Parker M., Beck, Christina M., Morse, Robert P., Garza-Sánchez, Fernando, Low, David A., Hayes, Christopher S., Goulding, Celia W.

“…Contact-dependent growth inhibition (CDI) is a widespread mechanism of bacterial competition. CDI⁺ bacteria deliver the toxic C-terminal region of…”
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Impacts of nitrogen application rates on the activity and diversity of denitrifying bacteria in the Broadbalk Wheat Experiment by Clark, Ian M., Buchkina, Natalya, Jhurreea, Deveraj, Goulding, Keith W. T., Hirsch, Penny R.

“…Bacterial denitrification results in the loss of fertilizer nitrogen and greenhouse gas emissions as nitrous oxides, but ecological factors in soil influencing…”
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Structural basis of toxicity and immunity in contact-dependent growth inhibition (CDI) systems by Morse, Robert P., Nikolakakis, Kiel C., Willett, Julia L. E., Gerrick, Elias, Low, David A., Hayes, Christopher S., Goulding, Celia W.

“…Contact-dependent growth inhibition (CDI) systems encode polymorphic toxin/immunity proteins that mediate competition between neighboring bacterial cells. We…”
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Unusual Diheme Conformation of the Heme-Degrading Protein from Mycobacterium tuberculosis by Chim, Nicholas, Iniguez, Angelina, Nguyen, Tran Que, Goulding, Celia W.

“…Heme degradation plays a pivotal role in the availability of the essential nutrient, iron, in pathogenic bacteria. A previously unannotated protein from…”
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Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake by de Miranda, Rodger, Cuthbert, Bonnie J, Klevorn, Thaís, Chao, Alex, Mendoza, Jessica, Arbing, Mark, Sieminski, Paul J, Papavinasasundaram, Kadamba, Abdul-Hafiz, Sumer, Chan, Sum, Sassetti, Christopher M, Ehrt, Sabine, Goulding, Celia W

“…Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, poses a great threat to human health. With the emergence of drug resistant Mtb strains,…”
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