Search Results - "Goulding, Eugenia H"

Phosphoglycerate Kinase 2 (PGK2) Is Essential for Sperm Function and Male Fertility in Mice by Danshina, Polina V, Geyer, Christopher B, Dai, Qunsheng, Goulding, Eugenia H, Willis, William D, Kitto, G. Barrie, McCarrey, John R, Eddy, E.M, O'Brien, Deborah A

“…Phosphoglycerate kinase 2 (PGK2), an isozyme that catalyzes the first ATP-generating step in the glycolytic pathway, is encoded by an autosomal retrogene that…”
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Glyceraldehyde 3-Phosphate Dehydrogenase-S, a Sperm-Specific Glycolytic Enzyme, Is Required for Sperm Motility and Male Fertility by Miki, Kiyoshi, Qu, Weidong, Goulding, Eugenia H., Willis, William D., Bunch, Donna O., Strader, Lillian F., Perreault, Sally D., Eddy, Edward M., O'Brien, Deborah A., Yanagimachi, Ryuzo

“…Although glycolysis is highly conserved, it is remarkable that several unique isozymes in this central metabolic pathway are found in mammalian sperm…”
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Impaired sperm fertilizing ability in mice lacking Cysteine-RIch Secretory Protein 1 (CRISP1) by Da Ros, Vanina G., Maldera, Julieta A., Willis, William D., Cohen, Débora J., Goulding, Eugenia H., Gelman, Diego M., Rubinstein, Marcelo, Eddy, Edward M., Cuasnicu, Patricia S.

“…Mammalian fertilization is a complex multi-step process mediated by different molecules present on both gametes. Epididymal protein CRISP1, a member of the…”
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Neonatal Exposure to Genistein Disrupts Ability of Female Mouse Reproductive Tract to Support Preimplantation Embryo Development and Implantation by Jefferson, Wendy N, Padilla-Banks, Elizabeth, Goulding, Eugenia H, Lao, Shin-Ping C, Newbold, Retha R, Williams, Carmen J

“…Female mice treated neonatally with the phytoestrogen genistein (50 mg/kg/day) have multioocyte follicles, lack regular estrous cyclicity, and are infertile…”
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Male infertility in mice lacking the store-operated Ca2+ channel Orai1 by Davis, Felicity M, Goulding, Eugenia H, D’Agostin, Diane M, Janardhan, Kyathanahalli S, Cummings, Connie A, Bird, Gary S, Eddy, Edward M, Putney, James W

“…Graphical abstract…”
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Transactivating function (AF) 2–mediated AF-1 activity of estrogen receptor α is crucial to maintain male reproductive tract function by Arao, Yukitomo, Hamilton, Katherine J., Goulding, Eugenia H., Janardhan, Kyathanahalli S., Eddy, Edward M., Korach, Kenneth S.

“…Estrogen receptor alpha (ERα) is a ligand-dependent transcription factor containing two transcriptional activation function (AF) domains. AF-1 is in the N…”
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Targeted Disruption of the Akap4 Gene Causes Defects in Sperm Flagellum and Motility by Miki, Kiyoshi, Willis, William D., Brown, Paula R., Goulding, Eugenia H., Fulcher, Kerry D., Eddy, Edward M.

“…A-kinase anchoring proteins (AKAPs) tether cyclic AMP-dependent protein kinases and thereby localize phosphorylation of target proteins and initiation of…”
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Protamine 2 Deficiency Leads to Sperm DNA Damage and Embryo Death in Mice by Cho, Chunghee, Jung-Ha, Haesook, Willis, William D, Goulding, Eugenia H, Stein, Paula, Xu, Zhe, Schultz, Richard M, Hecht, Norman B, Eddy, Edward M

“…Cytokinesis is incomplete in spermatogenic cells, and the descendants of each stem cell form a clonal syncytium. As a result, a heterozygous mutation in a gene…”
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Ex3αERKO male infertility phenotype recapitulates the αERKO male phenotype by Goulding, Eugenia H, Hewitt, Sylvia C, Nakamura, Noriko, Hamilton, Katherine, Korach, Kenneth S, Eddy, Edward M

“…Disruption of the Esr1 gene encoding estrogen receptor α (ERα) by insertion of a neomycin resistance gene (neo) into exon 2 (αERKO mice) was shown previously…”
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Heat shock protein 2 promoter drives cre expression in spermatocytes of transgenic mice by Inselman, Amy L., Nakamura, Noriko, Brown, Paula R., Willis, William D., Goulding, Eugenia H., Eddy, Edward M.

“…We generated transgenic mouse line C57BL/6‐Tg(Hspa2‐cre)1Eddy/J (Hspa2‐cre), which expresses cre‐recombinase under the control of a 907‐bp fragment of the heat…”
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Disruption of a Spermatogenic Cell-Specific Mouse Enolase 4 (Eno4) Gene Causes Sperm Structural Defects and Male Infertility1 by Nakamura, Noriko, Dai, Qunsheng, Williams, Jason, Goulding, Eugenia H, Willis, William D, Brown, Paula R, Eddy, Edward M

“…Sperm utilize glycolysis to generate ATP required for motility, and several spermatogenic cell-specific glycolytic isozymes are associated with the fibrous…”
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Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol by Davis, Vicki L., Newbold, Retha R., Couse, John F., Rea, Sheri L., Gallagher, Katie M., Hamilton, Katherine J., Goulding, Eugenia H., Jefferson, Wendy, Eddy, E.M., Bullock, Bill C., Korach, Kenneth S.

“…► ERΔ3 transgenic mice express the mouse ERα variant lacking the second zinc finger. ► Many tissues express ERΔ3; a higher ratio of ERα to ERΔ3 occurs in the…”
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Actin-related protein ACTL7B ablation leads to OAT with multiple morphological abnormalities of the flagellum and male infertility in mice by Clement, Tracy M., Geyer, Christopher B., Willis, William D., Goulding, Eugenia H., Upadhyay, Srijana, Eddy, Edward M.

“…The formation of fertilisation-competent sperm requires spermatid morphogenesis (spermiogenesis), a poorly understood program that involves complex coordinated…”
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Germ Cell-Specific Retinoic Acid Receptor α Functions in Germ Cell Organization, Meiotic Integrity, and Spermatogonia by Peer, Natalie R, Law, Sze Ming, Murdoch, Brenda, Goulding, Eugenia H, Eddy, Edward M, Kim, Kwanhee

“…Retinoic acid receptor α (RARA), a retinoic acid-dependent transcription factor, is expressed in both somatic and germ cells of the testis. Rara-null male mice…”
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Disruption of a Spermatogenic Cell-Specific Mouse Enolase 4 (Eno4) Gene Causes Sperm Structural Defects and Male Infertility by NAKAMURA, Noriko, QUNSHENG DAI, WILLIAMS, Jason, GOULDING, Eugenia H, WILLIS, William D, BROWN, Paula R, EDDY, Edward M

“…Sperm utilize glycolysis to generate ATP required for motility, and several spermatogenic cell-specific glycolytic isozymes are associated with the fibrous…”
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Expression of the Gene for Mouse Lactate Dehydrogenase C (Ldhc) Is Required for Male Fertility by Odet, Fanny, Duan, Chongwen, Willis, William D, Goulding, Eugenia H, Kung, Aisha, Eddy, Edward M, Goldberg, Erwin

“…The lactate dehydrogenase (LDH) protein family members characteristically are distributed in tissue- and cell type-specific patterns and serve as the terminal…”
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Phosphoglycerate Kinase 2 (PGK2) Is Essential for Sperm Function and Male Fertility in Mice1 by Danshina, Polina V, Geyer, Christopher B, Dai, Qunsheng, Goulding, Eugenia H, Willis, William D, Kitto, G. Barrie, McCarrey, John R, Eddy, E.M, O'Brien, Deborah A

“…Phosphoglycerate kinase 2 (PGK2), an isozyme that catalyzes the first ATP-generating step in the glycolytic pathway, is encoded by an autosomal retrogene that…”
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Disrupting Cyclin Dependent Kinase 1 in Spermatocytes Causes Late Meiotic Arrest and Infertility in Mice by Clement, Tracy M, Inselman, Amy L, Goulding, Eugenia H, Willis, William D, Eddy, Edward M

“…While cyclin dependent kinase 1 (CDK1) has a critical role in controlling resumption of meiosis in oocytes, its role has not been investigated directly in…”
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Neonatal Exposure to Genistein Disrupts Ability of Female Mouse Reproductive Tract to Support Preimplantation Embryo Development and Implantation1 by Jefferson, Wendy N, Padilla-Banks, Elizabeth, Goulding, Eugenia H, Lao, Shin-Ping C, Newbold, Retha R, Williams, Carmen J

“…Female mice treated neonatally with the phytoestrogen genistein (50 mg/kg/day) have multioocyte follicles, lack regular estrous cyclicity, and are infertile…”
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Rhox13 is required for a quantitatively normal first wave of spermatogenesis in mice by Busada, Jonathan T, Velte, Ellen K, Serra, Nicholas, Cook, Kenneth, Niedenberger, Bryan A, Willis, William D, Goulding, Eugenia H, Eddy, Edward M, Geyer, Christopher B

“…We previously described a novel germ cell-specific X-linked reproductive homeobox gene (Rhox13) that is upregulated at the level of translation in response to…”
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