Search Results - "Goulder, Philip J R"

Impact of MHC class I diversity on immune control of immunodeficiency virus replication by Goulder, Philip J. R, Watkins, David I

“…Key Points CD8 + T cells have a central role in immune control of HIV. However, the recent failure of a T-cell-based vaccine trial prompts an urgent refocus on…”
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The impact of differential antiviral immunity in children and adults by Prendergast, Andrew J., Klenerman, Paul, Goulder, Philip J. R.

“…Key Points The immune response is adapted at all stages of early life to maximize survival. These adaptations during intrauterine and early extrauterine life…”
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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression by Brown, Julia A, Kiepiela, Photini, Reddy, Sharon, DePierres, Chantal, Coovadia, Hoosen M, Altfeld, Marcus, Kaufmann, Daniel E, Wherry, E. John, Moodley, Eshia S, Goulder, Philip J. R, Freeman, Gordon J, Mackey, Elizabeth W, Leslie, Alasdair J, Eichbaum, Quentin, Zhu, Baogong, Klenerman, Paul, Mncube, Zenele, Walker, Bruce D, Miller, Joseph D, Ahmed, Rafi, Day, Cheryl L, Duraiswamy, Jaikumar

“…Functional impairment of T cells is characteristic of many chronic mouse and human viral infections. The inhibitory receptor programmed death 1 (PD-1; also…”
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HIV and SIV CTL escape: implications for vaccine design by Goulder, Philip J. R, Watkins, David I

“…Cytotoxic T lymphocytes (CTLs) have a central role in the successful control of immunodeficiency virus infection. Evasion of this immune response through CTL…”
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Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1 by Carlson, Jonathan M, Listgarten, Jennifer, Pfeifer, Nico, Tan, Vincent, Kadie, Carl, Walker, Bruce D, Ndung'u, Thumbi, Shapiro, Roger, Frater, John, Brumme, Zabrina L, Goulder, Philip J R, Heckerman, David

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Additive Contribution of HLA Class I Alleles in the Immune Control of HIV-1 Infection by LESLIE, Alasdair, MATTHEWS, Philippa C, GOULDER, Philip J. R, LISTGARTEN, Jennifer, CARLSON, Jonathan M, KADIE, Carl, NDUNG'U, Thumbi, BRANDER, Christian, COOVADIA, Hoosen, WALKER, Bruce D, HECKERMAN, David

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Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication by SCHNEIDEWIND, Arne, BROCKMAN, Mark A, KUNTZEN, Thomas, TUNG, Chang-Shung, LABUTE, Montiago X, MUELLER, Sandra M, HARRER, Thomas, MCMICHAEL, Andrew J, GOULDER, Philip J. R, AIKEN, Christopher, BRANDER, Christian, KELLEHER, Anthony D, RUIFENG YANG, ALLEN, Todd M, ADAM, Rahma I, BIN LI, LE GALL, Sylvie, RINALDO, Charles R, CRAGGS, Sharon L, ALLGAIER, Rachel L, POWER, Karen A

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Prevalence and Characteristics of Hepatitis B Virus (HBV) Coinfection among HIV-Positive Women in South Africa and Botswana by Matthews, Philippa C, Beloukas, Apostolos, Malik, Amna, Carlson, Jonathan M, Jooste, Pieter, Ogwu, Anthony, Shapiro, Roger, Riddell, Lynn, Chen, Fabian, Luzzi, Graz, Jaggernath, Manjeetha, Jesuthasan, Gerald, Jeffery, Katie, Ndung'u, Thumbi, Goulder, Philip J R, Geretti, Anna Maria, Klenerman, Paul

“…There is progressive concern about the evolving burden of morbidity and mortality caused by coinfection with HIV-1 and hepatitis B virus (HBV) in sub-Saharan…”
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Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection by CRAWFORD, Hayley, PRADO, Julia G, MULLINS, James I, KASLOW, Richard, GOEPFERT, Paul, ALLEN, Susan, HUNTER, Eric, MULENGA, Joseph, KIEPIELA, Photini, WALKER, Bruce D, GOULDER, Philip J. R, LESLIE, Alasdair, HUE, Stéphane, HONEYBORNE, Isobella, REDDY, Sharon, VAN DER STOK, Mary, MNCUBE, Zenele, BRANDER, Christian, ROUSSEAU, Christine

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Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence by Payne, Rebecca, Muenchhoff, Maximilian, Mann, Jaclyn, Roberts, Hannah E, Matthews, Philippa, Adland, Emily, Hempenstall, Allison, Huang, Kuan-Hsiang, Brockman, Mark, Brumme, Zabrina, Sinclair, Marc, Miura, Toshiyuki, Frater, John, Essex, Myron, Shapiro, Roger, Walker, Bruce D, Ndung'u, Thumbi, McLean, Angela R, Carlson, Jonathan M, Goulder, Philip J R

“…It is widely believed that epidemics in new hosts diminish in virulence over time, with natural selection favoring pathogens that cause minimal disease…”
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Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads by Rolland, Morgane, Heckerman, David, Deng, Wenjie, Rousseau, Christine M, Coovadia, Hoosen, Bishop, Karen, Goulder, Philip J R, Walker, Bruce D, Brander, Christian, Mullins, James I

“…HLA class-I alleles differ in their ability to control HIV replication through cell-mediated immune responses. No consistent associations have been found…”
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Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point by MATTHEWS, Philippa C, PRENDERGAST, Andrew, BRANDER, Christian, BISHOP, Karen, MLOTSHWA, Nonkululeko, MUFFINS, James I, COOVADIA, Hoosen, NDUNG'U, Thumbi, WALKER, Bruce D, HECKERMAN, David, GOULDER, Philip J. R, LESLIE, Alasdair, CRAWFORD, Hayley, PAYNE, Rebecca, ROUSSEAU, Christine, ROLLAND, Morgane, HONEYBORNE, Isobella, CARLSON, Jonathan, KADIE, Carl

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Gag-Protease-Mediated Replication Capacity in HIV-1 Subtype C Chronic Infection: Associations with HLA Type and Clinical Parameters by WRIGHT, Jaclyn K, BRUMME, Zabrina L, VAN DER STOK, Mary, MNCUBE, Zenele, BISHOP, Karen, GOULDER, Philip J. R, WALKER, Bruce D, BROCKMAN, Mark A, NDUNG'U, Thumbi, CARLSON, Jonathan M, HECKERMAN, David, KADIE, Carl M, BRUMME, Chanson J, BINGXIA WANG, LOSINA, Elena, MIURA, Toshiyuki, CHONCO, Fundisiwe

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HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model by McNaughton, Anna L, Lourenço, José, Hattingh, Louise, Adland, Emily, Daniels, Samantha, Van Zyl, Anriette, Akiror, Connie S, Wareing, Susan, Jeffery, Katie, Ansari, M Azim, Klenerman, Paul, Goulder, Philip J R, Gupta, Sunetra, Jooste, Pieter, Matthews, Philippa C

“…Sustainable Development Goals set a challenge for the elimination of hepatitis B virus (HBV) infection as a public health concern by the year 2030. Deployment…”
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Impact of HLA-B81-Associated Mutations in HIV-1 Gag on Viral Replication Capacity by Wright, Jaclyn K, Naidoo, Vanessa L, Brumme, Zabrina L, Prince, Jessica L, Claiborne, Daniel T, Goulder, Philip J. R, Brockman, Mark A, Hunter, Eric, Ndung'u, Thumbi

“…HIV-1 attenuation resulting from immune escape mutations selected in Gag may contribute to slower disease progression in HIV-1-infected individuals expressing…”
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Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag by Carlson, Jonathan M, Brumme, Zabrina L, Rousseau, Christine M, Brumme, Chanson J, Matthews, Philippa, Kadie, Carl, Mullins, James I, Walker, Bruce D, Harrigan, P Richard, Goulder, Philip J R, Heckerman, David

“…HIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape…”
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Immunodominant cytomegalovirus-specific CD8+ T-cell responses in sub-Saharan African populations by Malik, Amna, Adland, Emily, Laker, Leana, Kløverpris, Henrik, Fardoos, Rabiah, Roider, Julia, Severinsen, Mai C, Chen, Fabian, Riddell, Lynn, Edwards, Anne, Buus, Søren, Jooste, Pieter, Matthews, Philippa C, Goulder, Philip J R

“…More than 90% of children in Africa are infected with cytomegalovirus (CMV) by the age of 12 months. However, the high-frequency, immunodominant CD8+ T-cell…”
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Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA by Goulder, Philip J. R, Kiepiela, Photini, Leslie, Alasdair J, Honeyborne, Isobella, Ramduth, Danni, Thobakgale, Christina, Chetty, Senica, Rathnavalu, Prinisha, Moore, Corey, Pfafferott, Katja J, Hilton, Louise, Zimbwa, Peter, Moore, Sarah, Allen, Todd, Brander, Christian, Addo, Marylyn M, Altfeld, Marcus, James, Ian, Mallal, Simon, Bunce, Michael, Barber, Linda D, Szinger, James, Day, Cheryl, Klenerman, Paul, Mullins, James, Korber, Bette, Coovadia, Hoosen M, Walker, Bruce D

“…The extreme polymorphism in the human leukocyte antigen (HLA) class I region of the human genome is suggested to provide an advantage in pathogen defence…”
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Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B13 and Targeting of Multiple Gag-Specific CD8+ T-Cell Epitopes by HONEYBORNE, Isobella, PRENDERGAST, Andrew, VAN DER STOK, Mary, MCCARTHY, Noel, ROUSSEAU, Christine M, ADDO, Marylyn, MULLINS, James I, BRANDER, Christian, KIEPIELA, Photini, WALKER, Bruce D, GOULDER, Philip J. R, PEREYRA, Florencia, LESLIE, Alasdair, CRAWFORD, Hayley, PAYNE, Rebecca, REDDY, Shabashini, BISHOP, Karen, MOODLEY, Eshia, NAIR, Kriebashnie

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Rapid HIV disease progression following superinfection in an HLA-B27:05/B57:01-positive transmission recipient by Brener, Jacqui, Gall, Astrid, Hurst, Jacob, Batorsky, Rebecca, Lavandier, Nora, Chen, Fabian, Edwards, Anne, Bolton, Chrissy, Dsouza, Reena, Allen, Todd, Pybus, Oliver G, Kellam, Paul, Matthews, Philippa C, Goulder, Philip J R

“…The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain…”
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