Search Results - "Goulder, Philip"

HIV and HLA Class I: An Evolving Relationship by Goulder, Philip J.R., Walker, Bruce D.

“…Successful vaccine development for infectious diseases has largely been achieved in settings where natural immunity to the pathogen results in clearance in at…”
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Impact of MHC class I diversity on immune control of immunodeficiency virus replication by Goulder, Philip J. R, Watkins, David I

“…Key Points CD8 + T cells have a central role in immune control of HIV. However, the recent failure of a T-cell-based vaccine trial prompts an urgent refocus on…”
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Sex Differences in Pediatric Infectious Diseases by Muenchhoff, Maximilian, Goulder, Philip J. R.

“…The success of the immune response is finely balanced between, on the one hand, the need to engage vigorously with, and clear, certain pathogens; and, on the…”
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The impact of differential antiviral immunity in children and adults by Prendergast, Andrew J., Klenerman, Paul, Goulder, Philip J. R.

“…Key Points The immune response is adapted at all stages of early life to maximize survival. These adaptations during intrauterine and early extrauterine life…”
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Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point by Ndhlovu, Zaza M., Kamya, Philomena, Mewalal, Nikoshia, Kløverpris, Henrik N., Nkosi, Thandeka, Pretorius, Karyn, Laher, Faatima, Ogunshola, Funsho, Chopera, Denis, Shekhar, Karthik, Ghebremichael, Musie, Ismail, Nasreen, Moodley, Amber, Malik, Amna, Leslie, Alasdair, Goulder, Philip J.R., Buus, Søren, Chakraborty, Arup, Dong, Krista, Ndung’u, Thumbi, Walker, Bruce D.

“…CD8+ T cells contribute to the control of HIV, but it is not clear whether initial immune responses modulate the viral set point. We screened high-risk…”
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CD39 Expression Identifies Terminally Exhausted CD8+ T Cells by Gupta, Prakash K, Godec, Jernej, Wolski, David, Adland, Emily, Yates, Kathleen, Pauken, Kristen E, Cosgrove, Cormac, Ledderose, Carola, Junger, Wolfgang G, Robson, Simon C, Wherry, E John, Alter, Galit, Goulder, Philip J R, Klenerman, Paul, Sharpe, Arlene H, Lauer, Georg M, Haining, W Nicholas

“…Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of…”
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Epidemiology and impact of HIV coinfection with Hepatitis B and Hepatitis C viruses in Sub-Saharan Africa by Matthews, Philippa C, Geretti, Anna Maria, Goulder, Philip J.R, Klenerman, Paul

“…Abstract Human immunodeficiency virus (HIV), Hepatitis B (HBV) and Hepatitis C (HCV) are blood-borne viruses with potentially shared routes of transmission. In…”
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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression by Brown, Julia A, Kiepiela, Photini, Reddy, Sharon, DePierres, Chantal, Coovadia, Hoosen M, Altfeld, Marcus, Kaufmann, Daniel E, Wherry, E. John, Moodley, Eshia S, Goulder, Philip J. R, Freeman, Gordon J, Mackey, Elizabeth W, Leslie, Alasdair J, Eichbaum, Quentin, Zhu, Baogong, Klenerman, Paul, Mncube, Zenele, Walker, Bruce D, Miller, Joseph D, Ahmed, Rafi, Day, Cheryl L, Duraiswamy, Jaikumar

“…Functional impairment of T cells is characteristic of many chronic mouse and human viral infections. The inhibitory receptor programmed death 1 (PD-1; also…”
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HIV and SIV CTL escape: implications for vaccine design by Goulder, Philip J. R, Watkins, David I

“…Cytotoxic T lymphocytes (CTLs) have a central role in the successful control of immunodeficiency virus infection. Evasion of this immune response through CTL…”
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Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope by Dolton, Garry, Rius, Cristina, Hasan, Md Samiul, Wall, Aaron, Szomolay, Barbara, Behiry, Enas, Whalley, Thomas, Southgate, Joel, Fuller, Anna, Morin, Théo, Topley, Katie, Tan, Li Rong, Goulder, Philip J.R., Spiller, Owen B., Rizkallah, Pierre J., Jones, Lucy C., Connor, Thomas R., Sewell, Andrew K.

“…We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein269-277…”
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Paediatric HIV infection: the potential for cure by Goulder, Philip J., Lewin, Sharon R., Leitman, Ellen M.

“…Key Points Recent anecdotal reports of HIV remission in children following a discrete period of antiretroviral therapy (ART) have prompted the suggestion that…”
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HIV control: Is getting there the same as staying there? by Goulder, Philip, Deeks, Steven G

“…In this brief review and perspective, we address the question of whether the immune responses that bring about immune control of acute HIV infection are the…”
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Prevalence and Characteristics of Hepatitis B Virus (HBV) Coinfection among HIV-Positive Women in South Africa and Botswana by Matthews, Philippa C, Beloukas, Apostolos, Malik, Amna, Carlson, Jonathan M, Jooste, Pieter, Ogwu, Anthony, Shapiro, Roger, Riddell, Lynn, Chen, Fabian, Luzzi, Graz, Jaggernath, Manjeetha, Jesuthasan, Gerald, Jeffery, Katie, Ndung'u, Thumbi, Goulder, Philip J R, Geretti, Anna Maria, Klenerman, Paul

“…There is progressive concern about the evolving burden of morbidity and mortality caused by coinfection with HIV-1 and hepatitis B virus (HBV) in sub-Saharan…”
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Viral control in chronic HIV-1 subtype C infection is associated with enrichment of p24 IgG1 with Fc effector activity by Chung, Amy W, Mabuka, Jenniffer M, Ndlovu, Bongiwe, Licht, Anna, Robinson, Hannah, Ramlakhan, Yathisha, Ghebremichael, Musie, Reddy, Tarylee, Goulder, Philip J.R, Walker, Bruce D, Ndung’u, Thumbi, Alter, Galit

“…OBJECTIVE:Postinfection HIV viral control and immune correlates analysis of the RV144 vaccine trial indicate a potentially critical role for Fc…”
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In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction by Silva-Arrieta, Sandra, Goulder, Philip J R, Brander, Christian

“…[...]even for members of the HLA-A11 allele family that have very strict and limited C-anchor binding requirements, elution studies have demonstrated that only…”
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Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads by Rolland, Morgane, Heckerman, David, Deng, Wenjie, Rousseau, Christine M, Coovadia, Hoosen, Bishop, Karen, Goulder, Philip J R, Walker, Bruce D, Brander, Christian, Mullins, James I

“…HLA class-I alleles differ in their ability to control HIV replication through cell-mediated immune responses. No consistent associations have been found…”
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Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication by SCHNEIDEWIND, Arne, BROCKMAN, Mark A, KUNTZEN, Thomas, TUNG, Chang-Shung, LABUTE, Montiago X, MUELLER, Sandra M, HARRER, Thomas, MCMICHAEL, Andrew J, GOULDER, Philip J. R, AIKEN, Christopher, BRANDER, Christian, KELLEHER, Anthony D, RUIFENG YANG, ALLEN, Todd M, ADAM, Rahma I, BIN LI, LE GALL, Sylvie, RINALDO, Charles R, CRAGGS, Sharon L, ALLGAIER, Rachel L, POWER, Karen A

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Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1 by Carlson, Jonathan M, Listgarten, Jennifer, Pfeifer, Nico, Tan, Vincent, Kadie, Carl, Walker, Bruce D, Ndung'u, Thumbi, Shapiro, Roger, Frater, John, Brumme, Zabrina L, Goulder, Philip J R, Heckerman, David

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Additive Contribution of HLA Class I Alleles in the Immune Control of HIV-1 Infection by LESLIE, Alasdair, MATTHEWS, Philippa C, GOULDER, Philip J. R, LISTGARTEN, Jennifer, CARLSON, Jonathan M, KADIE, Carl, NDUNG'U, Thumbi, BRANDER, Christian, COOVADIA, Hoosen, WALKER, Bruce D, HECKERMAN, David

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Two Distinct Mechanisms Leading to Loss of Virological Control in the Rare Group of Antiretroviral Therapy-Naive, Transiently Aviremic Children Living with HIV by Vieira, Vinicius A, Adland, Emily, Grayson, Nicholas E, Csala, Anna, Richards, Fa'eeda, Dacon, Cherrelle, Athavale, Rohin, Tsai, Ming-Han, D'Souza, Reena, Muenchhoff, Maximilian, Bonsall, David, Jooste, Pieter, Goulder, Philip J R

“…HIV-specific CD8 T cells play a central role in immune control of adult HIV, but their contribution in pediatric infection is less well characterized…”
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