Lipoprotein(a) levels in black and white children and adolescents with IDDM

Lipoprotein(a) levels in black and white children and adolescents with IDDM. L L Levitsky , A M Scanu and S H Gould Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Illinois. Abstract OBJECTIVE: To examine the relationship between levels of lipoprotein(a) [Lp(a)], diabet...

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Published in:	Diabetes care Vol. 14; no. 4; pp. 283 - 287
Main Authors:	Levitsky, L.L. (Massachusetts General Hospital, Boston, MA), Scanu, A.M, Gould, S.H
Format:	Journal Article
Language:	English
Published:	Alexandria, VA American Diabetes Association 01-04-1991
Subjects:	Adolescent African Continental Ancestry Group Analysis of Variance APOLIPOPROTEINS Associated diseases and complications Biological and medical sciences BLOOD LIPIDS caucasians Child CHILDREN COMPARISONS DIABETE DIABETES Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - ethnology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies ENFANT ETHNIC GROUPS European Continental Ancestry Group Female GENETIC MARKERS Glycated Hemoglobin A - analysis glycosylated hemoglobin GROUPE ETHNIQUE GRUPOS ETNICOS HAEMOGLOBIN HEMOGLOBINA HEMOGLOBINE HIPERGLICEMIA Humans HYPERGLYCAEMIA HYPERGLYCEMIE JEUNESSE JUVENTUD LIPAEMIA LIPEMIA LIPEMIE Lipoprotein(a) LIPOPROTEINAS LIPOPROTEINE LIPOPROTEINS Lipoproteins - blood Male MARCADORES GENETICOS MARQUEUR GENETIQUE Medical sciences NINOS Regression Analysis YOUTH Human Endocrinopathy Hyperglycemia Adolescent Race Insulin dependent diabetes Negroid Lipids Lipoprotein Caucasoid Metabolism Comparative study
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Summary:	Lipoprotein(a) levels in black and white children and adolescents with IDDM. L L Levitsky , A M Scanu and S H Gould Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Illinois. Abstract OBJECTIVE: To examine the relationship between levels of lipoprotein(a) [Lp(a)], diabetes, and glycemic control in white and black nondiabetic control and insulin-dependent diabetic (IDDM) children and adolescents, fasting blood analyses were conducted on a subject sample drawn from referral-based diabetes and endocrine clinics and a primary-care general pediatric clinic. RESEARCH DESIGN AND METHODS: Thirty-six white and 16 black children with IDDM who volunteered to participate in this study were compared with 30 white and 42 black nondiabetic control children. RESULTS: Lp(a) protein levels were significantly higher (P less than 0.05) in both groups of black children compared with whites (black vs. white nondiabetic children 6.8 +/- 0.95 vs. 3.1 +/- 0.68 mg/dl and black vs. white diabetic children 7.5 +/- 1.52 vs. 3.0 +/- 0.64 mg/dl). Lp(a) protein levels directly correlated with the level of glycosylated hemoglobin (r = 0.46, P less than 0.01) in white diabetic children but not in black diabetic children. Well-controlled white diabetic children (n = 12, glycosylated hemoglobin less than 10%) had a mean Lp(a) protein level of 1.4 +/- 0.3 mg/dl compared with poorly controlled white diabetic children (n = 10, glycosylated hemoglobin greater than 13%) whose mean Lp(a) protein level was 5.7 +/- 1.7 mg/dl (P less than 0.01). CONCLUSIONS: We conclude that circulating levels of Lp(a) protein are increased in hyperglycemia. A genetically determined elevated level of Lp(a) is a risk factor for atherosclerotic disease in white and Asian adults. Elevated Lp(a) should be investigated as an independent risk factor for atherosclerotic disease in IDDM. It could prove to be an additional mechanism for the development of diabetic complications in selected populations.
Bibliography:	9121550 S30 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0149-5992 1935-5548
DOI:	10.2337/diacare.14.4.283