Search Results - "Gould, Robert W."

Editorial: Sleep and circadian rhythm disruptions associated with substance use disorders by Berro, Lais F, España, Rodrigo A, Mong, Jessica A, Gould, Robert W

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Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders by Fisher, Nicole M., Gould, Robert W., Gogliotti, Rocco G., McDonald, Annalise J., Badivuku, Hana, Chennareddy, Susmita, Buch, Aditi B., Moore, Annah M., Jenkins, Matthew T., Robb, W. Hudson, Lindsley, Craig W., Jones, Carrie K., Conn, P. Jeffrey, Niswender, Colleen M.

“…Neurodevelopmental disorders are characterized by deficits in communication, cognition, attention, social behavior and/or motor control. Previous studies have…”
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Use of Quantitative Electroencephalography to Inform Age- and Sex-Related Differences in NMDA Receptor Function Following MK-801 Administration by Holter, Kimberly M, Lekander, Alex D, Pierce, Bethany E, Sands, L Paul, Gould, Robert W

“…Sex- and age-related differences in symptom prevalence and severity have been widely reported in patients with schizophrenia, yet the underlying mechanisms…”
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Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents by Bubser, Michael, Bridges, Thomas M, Dencker, Ditte, Gould, Robert W, Grannan, Michael, Noetzel, Meredith J, Lamsal, Atin, Niswender, Colleen M, Daniels, J. Scott, Poslusney, Michael S, Melancon, Bruce J, Tarr, James C, Byers, Frank W, Wess, Jürgen, Duggan, Mark E, Dunlop, John, Wood, Michael W, Brandon, Nicholas J, Wood, Michael R, Lindsley, Craig W, Conn, P. Jeffrey, Jones, Carrie K

“…Positive allosteric modulators (PAMs) of the M4 muscarinic acetylcholine receptor (mAChR) represent a novel approach for the treatment of psychotic symptoms…”
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Partial mGlu5 Negative Allosteric Modulator M-5MPEP Demonstrates Antidepressant-Like Effects on Sleep Without Affecting Cognition or Quantitative EEG by Holter, Kimberly M., Lekander, Alex D., LaValley, Christina M., Bedingham, Elizabeth G., Pierce, Bethany E., Sands, L. Paul, Lindsley, Craig W., Jones, Carrie K., Gould, Robert W.

“…Selective negative allosteric modulators (NAMs) targeting the metabotropic glutamate receptor subtype 5 (mGlu 5 ) demonstrate anxiolytic-like and…”
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Standardizing Care for High-Risk Patients in Spine Surgery: The Northwestern High-Risk Spine Protocol by HALPIN, Ryan J, SUGRUE, Patrick A, GOULD, Robert W, KALLAS, Peter G, SCHAFER, Michael F, ONDRA, Stephen L, KOSKI, Tyler R

“…Review article of current literature on the preoperative evaluation and postoperative management of patients undergoing high-risk spine operations and a…”
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Positron emission tomography imaging studies of dopamine receptors in primate models of addiction by Nader, Michael A, Czoty, Paul W, Gould, Robert W, Riddick, Natallia V

“…Animal models have provided valuable information related to trait and state variables associated with vulnerability to drug addiction. Our brain imaging…”
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Pulmonary tumor embolism secondary to soft tissue and bone sarcomas: a case report and literature review by Latchana, Nicholas, Daniel, Vincent C, Gould, Robert W, Pollock, Raphael E

“…Tumor embolisms (TE) are an underappreciated source of pulmonary embolisms in sarcoma. Most evidence in the literature is limited to case reports and none have…”
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State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 – Relation to antipsychotic-like drug effects by Gould, Robert W., Nedelcovych, Michael T., Gong, Xuewen, Tsai, Erica, Bubser, Michael, Bridges, Thomas M., Wood, Michael R., Duggan, Mark E., Brandon, Nicholas J., Dunlop, John, Wood, Michael W., Ivarsson, Magnus, Noetzel, Meredith J., Daniels, J. Scott, Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K.

“…Accumulating evidence indicates direct relationships between sleep abnormalities and the severity and prevalence of other symptom clusters in schizophrenia…”
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Mass Spectrometry-Based Proteome Profiling of Extracellular Vesicles Derived from the Cerebrospinal Fluid of Adult Rhesus Monkeys Exposed to Cocaine throughout Gestation by Rather, Hilal A, Mishra, Shalini, Su, Yixin, Kumar, Ashish, Singh, Sangeeta, Misra, Biswapriya B, Lee, Jingyun, Furdui, Cristina M, Hamilton, Lindsey R, Gould, Robert W, Nader, Susan H, Nader, Michael A, Deep, Gagan

“…Cocaine use disorder has been reported to cause transgenerational effects. However, due to the lack of standardized biomarkers, the effects of cocaine use…”
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A Rodent Model of Traumatic Stress Induces Lasting Sleep and Quantitative Electroencephalographic Disturbances by Nedelcovych, Michael T, Gould, Robert W, Zhan, Xiaoyan, Bubser, Michael, Gong, Xuewen, Grannan, Michael, Thompson, Analisa T, Ivarsson, Magnus, Lindsley, Craig W, Conn, P. Jeffrey, Jones, Carrie K

“…Hyperarousal and sleep disturbances are common, debilitating symptoms of post-traumatic stress disorder (PTSD). PTSD patients also exhibit abnormalities in…”
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Selective M5 muscarinic acetylcholine receptor negative allosteric modulator VU6008667 blocks acquisition of opioid self-administration by Teal, Laura B., Bubser, Michael, Duncan, Edith, Gould, Robert W., Lindsley, Craig W., Jones, Carrie K.

“…Recent evidence suggests that inhibition of the M5 muscarinic acetylcholine receptor (mAChR) may provide a novel non-opioid mechanism for the treatment of…”
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Cognitive performance as a behavioral phenotype associated with cocaine self-administration in female and male socially housed monkeys by Allen, Mia I, Costa, Marissa B, Johnson, Bernard N, Gould, Robert W, Nader, Michael A

“…Considerable research has suggested that certain cognitive domains may contribute to cocaine misuse. However, there are gaps in the literature regarding…”
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Metabotropic glutamate receptor function and regulation of sleep-wake cycles by Holter, Kimberly M, Pierce, Bethany E, Gould, Robert W

“…Metabotropic glutamate (mGlu) receptors are the most abundant family of G-protein coupled receptors and are widely expressed throughout the central nervous…”
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Effects of oxycodone self‐administration on sleep duration and quality in male and female rats by Pierce, Bethany E., Holter, Kimberly, Morton, Alison, Lekander, Alex, Bedingham, Elizabeth, Curry, Ryan, Gould, Robert W.

“…Many symptoms associated with opioid withdrawal contribute to continued used and relapse. Long‐lasting sleep disturbances are common symptoms of opioid use and…”
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Systemic Lidocaine to Improve Quality of Recovery after Laparoscopic Bariatric Surgery: A Randomized Double-Blinded Placebo-Controlled Trial by De Oliveira, Gildasio S., Duncan, Kenyon, Fitzgerald, Paul, Nader, Antoun, Gould, Robert W., McCarthy, Robert J.

“…Background Few multimodal strategies to minimize postoperative pain and improve recovery have been examined in morbidly obese patients undergoing laparoscopic…”
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Chronic levetiracetam (Keppra®) treatment increases the reinforcing strength of cocaine in rhesus monkeys by Czoty, Paul W., Gould, Robert W., O'Donovan, Cormac A., Nader, Michael A.

“…Drugs that increase inhibitory neuronal activity in the brain have been proposed as potential medications for stimulant use disorders. The present study…”
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PET studies in nonhuman primate models of cocaine abuse: Translational research related to vulnerability and neuroadaptations by Gould, Robert W., Duke, Angela N., Nader, Michael A.

“…The current review highlights the utility of positron emission tomography (PET) imaging to study the neurobiological substrates underlying vulnerability to…”
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Modulation of arousal and sleep/wake architecture by M1 PAM VU0453595 across young and aged rodents and nonhuman primates by Gould, Robert W., Russell, Jason K., Nedelcovych, Michael T., Bubser, Michael, Blobaum, Anna L., Bridges, Thomas M., Newhouse, Paul A., Lindsley, Craig W., Conn, P. Jeffrey, Nader, Michael A., Jones, Carrie K.

“…Degeneration of basal forebrain cholinergic circuitry represents an early event in the development of Alzheimer’s disease (AD). These alterations in central…”
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Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154 by Gould, Robert W., Grannan, Michael D., Gunter, Barak W., Ball, Jacob, Bubser, Michael, Bridges, Thomas M., Wess, Jurgen, Wood, Michael W., Brandon, Nicholas J., Duggan, Mark E., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K.

“…Although selective activation of the M1 muscarinic acetylcholine receptor (mAChR) subtype has been shown to improve cognitive function in animal models of…”
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