Search Results - "Gould, Keith G"

Breakdown of T-cell ignorance: The tolerance failure responsible for mainstream autoimmune diseases? by Salaman, Myer R., Gould, Keith G.

“…This article explores the possibility that the major autoimmune diseases come about because of the breakdown of T lymphocyte ignorance – that state in which…”
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Basic and translational applications of engineered MHC class I proteins by Hansen, Ted H, Connolly, Janet M, Gould, Keith G, Fremont, Daved H

“…Major histocompatibility complex (MHC) class I molecules can be engineered as single chain trimers (SCTs) that sequentially incorporate all three subunits of…”
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Properties and applications of single-chain major histocompatibility complex class I molecules by Kotsiou, Eleni, Brzostek, Joanna, Gould, Keith G

“…Stable major histocompatibility complex (MHC) class I molecules at the cell surface consist of three separate, noncovalently associated components: the class I…”
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Peptide-Major Histocompatibility Complex Dimensions Control Proximal Kinase-Phosphatase Balance during T Cell Activation by Choudhuri, Kaushik, Parker, Mathew, Milicic, Anita, Cole, David K., Shaw, Michael K., Sewell, Andrew K., Stewart-Jones, Guillaume, Dong, Tao, Gould, Keith G., van der Merwe, P. Anton

“…T cell antigen recognition requires binding of the T cell receptor (TCR) to a complex between peptide antigen and major histocompatibility complex molecules…”
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Richard Pfeiffer’s typhoid vaccine and Almroth Wright’s claim to priority by Williamson, John D., Gould, Keith G., Brown, Kevin

“…Following the 1892 cholera pandemic, Richard Pfeiffer, Director of the science section of Robert Koch’s Institute for Hygiene in Berlin, began laboratory-based…”
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Dimerization of soluble disulfide trap single-chain major histocompatibility complex class I molecules dependent on peptide binding affinity by Kotsiou, Eleni, Brzostek, Joanna, Lenart, Izabela, Antoniou, Antony N, Dyson, Julian, Gould, Keith G

“…Stable presentation of peptide epitope by major histocompatibility complex (MHC) class I molecules is a prerequisite for the efficient expansion of CD8(+) T…”
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High Circulating Frequencies of Tumor Necrosis Factor Alpha- and Interleukin-2-Secreting Human T-Lymphotropic Virus Type 1 (HTLV-1)-Specific CD4+ T Cells in Patients with HTLV-1-Associated Neurological Disease by Goon, Peter K C, Igakura, Tadahiko, Hanon, Emmanuel, Mosley, Angelina J, Asquith, Becca, Gould, Keith G, Taylor, Graham P, Weber, Jonathan N, Bangham, Charles R M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Endoplasmic Reticulum Degradation–Enhancing α‐Mannosidase–like Protein 1 Targets Misfolded HLA–B27 Dimers for Endoplasmic Reticulum–Associated Degradation by Guiliano, David B., Fussell, Helen, Lenart, Izabela, Tsao, Edward, Nesbeth, Darren, Fletcher, Adam J., Campbell, Elaine C., Yousaf, Nasim, Williams, Sarah, Santos, Susana, Cameron, Amy, Towers, Greg J., Kellam, Paul, Hebert, Daniel N., Gould, Keith G., Powis, Simon J., Antoniou, Antony N.

“…Objective HLA–B27 forms misfolded heavy chain dimers, which may predispose individuals to inflammatory arthritis by inducing endoplasmic reticulum (ER) stress…”
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Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC by Hoerter, John A H, Brzostek, Joanna, Artyomov, Maxim N, Abel, Steven M, Casas, Javier, Rybakin, Vasily, Ampudia, Jeanette, Lotz, Carina, Connolly, Janet M, Chakraborty, Arup K, Gould, Keith G, Gascoigne, Nicholas R J

“…Recent work has demonstrated that nonstimulatory endogenous peptides can enhance T cell recognition of antigen, but MHCI- and MHCII-restricted systems have…”
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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation by Zhao, Xiang, Hamidinia, Maryam, Choo, Joanna Ai Ling, Too, Chien Tei, Ho, Zi Zong, Ren, Ee Chee, Bertoletti, Antonio, MacAry, Paul A, Gould, Keith G, Brzostek, Joanna, Gascoigne, Nicholas R J

“…Non-stimulatory self peptide MHC (pMHC) complexes do not induce T cell activation and effector functions, but can enhance T cell responses to agonist pMHC,…”
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Ligand dimensions are important in controlling NK-cell responses by Brzostek, Joanna, Chai, Jian-Guo, Gebhardt, Friedemann, Busch, Dirk H, Zhao, Rui, van der Merwe, P. Anton, Gould, Keith G

“…Size-dependent protein segregation at the cell-cell contact interface has been suggested to be critical for regulation of lymphocyte function. We investigated…”
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Proliferation assay amplification by IL-2 in model primary and recall antigen systems by Kennell, Amy S M, Gould, Keith G, Salaman, Myer R

“…It can be difficult to register a weak proliferative response of T lymphocytes to an antigen, particularly in a simple culture system of peripheral blood…”
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Human T cell lymphotropic virus (HTLV) type-1-specific CD8+T cells: Frequency and immunodominance hierarchy by GOON, Peter K. C, BIANCARDI, Alix, BANGHAM, Charles R. M, FAST, Noam, IGAKURA, Tadahiko, HANON, Emmanuel, MOSLEY, Angelina J, ASQUITH, Becca, GOULD, Keith G, MARSHALL, Sara, TAYLOR, Graham P

“…Human T cell lymphotropic virus type 1 (HTLV-1) causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We used interferon- gamma…”
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Competition Between MHC Class I Alleles for Cell Surface Expression Alters CTL Responses to Influenza A Virus by Tourdot, Sophie, Gould, Keith G

“…Mammalian cells express up to six different MHC class I alleles, many of which differ in terms of their interaction with components of the Ag presentation…”
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A Single-Chain H-2Db Molecule Presenting an Influenza Virus Nucleoprotein Epitope Shows Enhanced Ability at Stimulating CD8+ T Cell Responses In Vivo by Palmowski, Michael J, Parker, Mathew, Choudhuri, Kaushik, Chiu, Christopher, Callan, Margaret F. C, van der Merwe, P. Anton, Cerundolo, Vincenzo, Gould, Keith G

“…We have generated a construct encoding a single-chain H-2D(b) mouse MHC class I molecule in which an influenza virus nucleoprotein (NP) epitope, amino acid…”
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Characterization of a new H-2Dk-restricted epitope prominent in primary influenza A virus infection by Tourdot, Sophie, Herath, Shan, Gould, Keith G

“…Department of Immunology, Imperial College School of Medicine (St Mary’s Campus), Norfolk Place, London W2 1PG, UK 1 Author for correspondence: Keith Gould…”
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Presentation of a new H-2D(k)-restricted epitope in the Tax protein of human T-lymphotropic virus type I is enhanced by the proteasome inhibitor lactacystin by Lomas, Mehnaaz, Hanon, Emmanuel, Tanaka, Yuetsu, Bangham, Charles R M, Gould, Keith G

“…Tax, the trans-activator of human T-lymphotropic virus type I (HTLV-I), is the dominant target antigen for cytotoxic T lymphocytes (CTLs) in the majority of…”
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Presentation of a new H-2Dk-restricted epitope in the Tax protein of human T-lymphotropic virus type I is enhanced by the proteasome inhibitor lactacystin by Lomas, Mehnaaz, Hanon, Emmanuel, Tanaka, Yuetsu, Bangham, Charles R. M, Gould, Keith G

“…Department of Immunology, Imperial College School of Medicine (St Mary’s Campus), Norfolk Place, London W2 1PG, UK 1 Department of Infectious Disease and…”
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Differential processing and presentation of the H-2D(b)-restricted epitope from two different strains of influenza virus nucleoprotein by Potter, Paul, Tourdot, Sophie, Blanchard, Tom, Smith, Geoffrey L, Gould, Keith G

“…The influenza virus strains A/NT/60/68 and A/PR/8/34 both have an immunodominant D(b)-restricted epitope in their nucleoprotein (NP) at amino acid residues…”
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Differential processing and presentation of the H-2Db-restricted epitope from two different strains of influenza virus nucleoprotein by Potter, Paul, Tourdot, Sophie, Blanchard, Tom, Smith, Geoffrey L, Gould, Keith G

“…Department of Immunology, Imperial College School of Medicine (St Mary’s Campus), Norfolk Place, London W2 1PG, UK 1 Sir William Dunn School of Pathology,…”
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