Search Results - "Gould, H J"

Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps by Gevaert, P., Nouri‐Aria, K. T., Wu, H., Harper, C. E., Takhar, P., Fear, D. J., Acke, F., De Ruyck, N., Banfield, G., Kariyawasam, H. H., Bachert, C., Durham, S. R., Gould, H. J.

“…Background Chronic rhinosinusitis with nasal polyps (NP) and allergic rhinitis (AR) is characterized by local Th2 inflammation and up‐regulation of IgE;…”
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Local IgE in non-allergic rhinitis by Campo, P., Rondón, C., Gould, H. J., Barrionuevo, E., Gevaert, P., Blanca, M.

“…Summary Local allergic rhinitis (LAR) is characterized by the presence of a nasal Th2 inflammatory response with local production of specific IgE antibodies…”
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Epidemiological associations of allergy, IgE and cancer by Josephs, D. H., Spicer, J. F., Corrigan, C. J., Gould, H. J., Karagiannis, S. N.

“…Summary Several epidemiological studies have evaluated potential associations between allergy and risk of malignancy. It remains clear that the relationship…”
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AllergoOncology: ultra‐low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI) by Ferastraoaru, D., Bax, H. J., Bergmann, C., Capron, M., Castells, M., Dombrowicz, D., Fiebiger, E., Gould, H. J., Hartmann, K., Jappe, U., Jordakieva, G., Josephs, D. H., Levi‐Schaffer, F., Mahler, V., Poli, A., Rosenstreich, D., Roth‐Walter, F., Shamji, M., Steveling‐Klein, E. H., Turner, M. C., Untersmayr, E., Karagiannis, S. N., Jensen‐Jarolim, E.

“…Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and…”
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Ontogeny of human IgE‐expressing B cells and plasma cells by Ramadani, F., Bowen, H., Upton, N., Hobson, P. S., Chan, Y.‐C., Chen, J.‐B., Chang, T. W., McDonnell, J. M., Sutton, B. J., Fear, D. J., Gould, H. J.

“…Background IgE‐expressing (IgE+) plasma cells (PCs) provide a continuous source of allergen‐specific IgE that is central to allergic responses. The extreme…”
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AllergoOncology: Opposite outcomes of immune tolerance in allergy and cancer by Jensen‐Jarolim, E., Bax, H. J., Bianchini, R., Crescioli, S., Daniels‐Wells, T. R., Dombrowicz, D., Fiebiger, E., Gould, H. J., Irshad, S., Janda, J., Josephs, D. H., Levi‐Schaffer, F., O′Mahony, L., Pellizzari, G., Penichet, M. L., Redegeld, F., Roth‐Walter, F., Singer, J., Untersmayr, E., Vangelista, L., Karagiannis, S. N.

“…While desired for the cure of allergy, regulatory immune cell subsets and nonclassical Th2‐biased inflammatory mediators in the tumour microenvironment can…”
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The human IgE network by Sutton, B. J, Gould, H. J

“…IgE and its receptors are believed to have evolved as a mechanism to protect mammals against parasites. But other and intrinsically innocuous antigens can…”
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Human IgE against the major allergen Bet v 1 - defining an epitope with limited cross-reactivity between different PR-10 family proteins by Levin, M., Davies, A. M., Liljekvist, M., Carlsson, F., Gould, H. J., Sutton, B. J., Ohlin, M.

“…Summary Background The interaction between IgE and allergen is a key event at the initiation of an allergic response, and its characteristics have substantial…”
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IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action by McDonnell, J.M, Dhaliwal, B, Sutton, B.J, Gould, H.J

“…The evolution of IgE in mammals added an extra layer of immune protection at body surfaces to provide a rapid and local response against antigens from the…”
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A possible role for nerve growth factor in the augmentation of sodium channels in models of chronic pain by Gould, Harry J., Gould, Trevor N., England, John D., Paul, Dennis, Liu, Z.P., Levinson, S.Rock

“…Inflammation induces an upregulation of sodium channels in sensory neurons. This most likely occurs as a result of the retrograde transport of cytochemical…”
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AllergoOncology – the impact of allergy in oncology: EAACI position paper by Jensen‐Jarolim, E., Bax, H. J., Bianchini, R., Capron, M., Corrigan, C., Castells, M., Dombrowicz, D., Daniels‐Wells, T. R., Fazekas, J., Fiebiger, E., Gatault, S., Gould, H. J., Janda, J., Josephs, D. H., Karagiannis, P., Levi‐Schaffer, F., Meshcheryakova, A., Mechtcheriakova, D., Mekori, Y., Mungenast, F., Nigro, E. A., Penichet, M. L., Redegeld, F., Saul, L., Singer, J., Spicer, J. F., Siccardi, A. G., Spillner, E., Turner, M. C., Untersmayr, E., Vangelista, L., Karagiannis, S. N.

“…Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported…”
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Inhibition of allergen‐dependent IgE activity by antibodies of the same specificity but different class by Dodev, T. S., Bowen, H., Shamji, M. H., Bax, H. J., Beavil, A. J., McDonnell, J. M., Durham, S. R., Sutton, B. J., Gould, H. J., James, L. K.

“…IgG4 purified from patients undergoing specific allergen immunotherapy inhibits the activities of the serum IgE in in vitro assays and is thought to reduce the…”
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Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcɛRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity by Rudman, S. M., Josephs, D. H., Cambrook, H., Karagiannis, P., Gilbert, A. E., Dodev, T., Hunt, J., Koers, A., Montes, A., Taams, L., Canevari, S., Figini, M., Blower, P. J., Beavil, A. J., Nicodemus, C. F., Corrigan, C., Kaye, S. B., Nestle, F. O., Gould, H. J., Spicer, J. F., Karagiannis, S. N.

“…Summary Background IgE antibodies, sequestered into tissues and retained locally by the high‐affinity IgE receptor, FcɛRI, on powerful effector cells such as…”
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Rapid sodium channel augmentation in response to inflammation induced by complete Freund's adjuvant by Gould, Harry J., England, John D., Liu, Z.P., Levinson, S.Rock

“…The mechanisms by which inflammation induces a chronic pain state are poorly understood. Following the induction of many painful conditions, an increase in the…”
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An immunologically relevant rodent model demonstrates safety of therapy using a tumour‐specific IgE by Josephs, D. H., Nakamura, M., Bax, H. J., Dodev, T. S., Muirhead, G., Saul, L., Karagiannis, P., Ilieva, K. M., Crescioli, S., Gazinska, P., Woodman, N., Lombardelli, C., Kareemaghay, S., Selkirk, C., Lentfer, H., Barton, C., Canevari, S., Figini, M., Downes, N., Dombrowicz, D., Corrigan, C. J., Nestle, F. O., Jones, P. S., Gould, H. J., Blower, P. J., Tsoka, S., Spicer, J. F., Karagiannis, S. N.

“…Background Designing biologically informative models for assessing the safety of novel agents, especially for cancer immunotherapy, carries substantial…”
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Intrinsic properties of germinal center‐derived B cells promote their enhanced class switching to IgE by Ramadani, F., Upton, N., Hobson, P., Chan, Y.‐C., Mzinza, D., Bowen, H., Kerridge, C., Sutton, B. J., Fear, D. J., Gould, H. J.

“…Background Research on the origins and development of human IgE‐expressing (IgE+) cells is required for understanding the pathogenesis of allergy and asthma…”
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The relationship of corpus callosum connections to electrical stimulation maps of motor, supplementary motor, and the frontal eye fields in owl monkeys by Gould, 3rd, H J, Cusick, C G, Pons, T P, Kaas, J H

“…Microstimulation and anatomical techniques were combined to reveal the organization and interhemispheric connections of motor cortex in owl monkeys. Movements…”
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Development of inflammatory hypersensitivity and augmentation of sodium channels in rat dorsal root ganglia by Gould, H.J., Gould, T.N., Paul, D., England, J.D., Liu, Z.P., Reeb, S.C., Levinson, S.R.

“…The development of thermal allodynia in relationship to sodium channel augmentation in dorsal root ganglia (DRGs) was studied in albino rats. Paw withdrawal…”
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Epitope specificity determines cross‐protection of a SIT‐induced IgG4 antibody by Gadermaier, E., James, L. K., Shamji, M. H., Blatt, K., Fauland, K., Zieglmayer, P., Garmatiuk, T., Focke‐Tejkl, M., Villalba, M., Beavil, R., Keller, W., Valent, P., Durham, S. R., Gould, H. J., Flicker, S., Valenta, R.

“…Background The calcium‐binding 2EF‐hand protein Phl p 7 from timothy grass pollen is a highly cross‐reactive pollen pan‐allergen that can induce severe…”
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α-Helical Coiled-Coil Stalks in the Low-Affinity Receptor for IgE (FcεRII/CD23) and Related C-Type Lectins by Beavil, Andrew J., Edmeades, Rebecca L., Gould, Hannah J., Sutton, Brian J.

“…The low-affinity receptor for IgE (FcεRII/CD23) is a cell surface glycoprotein that plays a role in both cellular immunity and allergic inflammation. Its…”
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