Search Results - "Gould, David J"

Metabolic requirements of Th17 cells and of B cells: Regulation and defects in health and in inflammatory diseases by Bystrom, Jonas, Taher, Taher E., Henson, Sian M., Gould, David J., Mageed, Rizgar A.

“…The immune system protects from infections and cancer through complex cellular networks. For this purpose, immune cells require well-developed mechanisms of…”
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Polylactic Acid-Based Patterned Matrixes for Site-Specific Delivery of Neuropeptides On-Demand: Functional NGF Effects on Human Neuronal Cells by Sindeeva, Olga A, Kopach, Olga, Kurochkin, Maxim A, Sapelkin, Andrei, Gould, David J, Rusakov, Dmitri A, Sukhorukov, Gleb B

“…The patterned microchamber arrays based on biocompatible polymers are a versatile cargo delivery system for drug storage and site-/time-specific drug release…”
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Glaucoma-causing ADAMTS17 mutations are also reproducibly associated with height in two domestic dog breeds: selection for short stature may have contributed to increased prevalence of glaucoma by Jeanes, Emily C, Oliver, James A C, Ricketts, Sally L, Gould, David J, Mellersh, Cathryn S

“…In humans, mutations are known to cause Weill-Marchesani-like syndrome, which is characterised by lenticular myopia, ectopia lentis, glaucoma, spherophakia,…”
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Local and Sustained Activity of Doxycycline Delivered with Layer-by-Layer Microcapsules by Luo, Dong, Gould, David J, Sukhorukov, Gleb B

“…Achieving localized delivery of small molecule drugs has the potential to increase efficacy and reduce off target and side effects associated with systemic…”
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Gene therapy for autoimmune diseases: quo vadis ? by Chernajovsky, Yuti, Gould, David J, Podhajcer, Osvaldo L

“…Biological therapies using antibodies and cytokines are becoming widespread for the treatment of chronic inflammatory autoimmune diseases. However, these…”
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Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated P. pyralis Luciferase by Popov, Anton L, Popova, Nelli, Gould, David J, Shcherbakov, Alexander B, Sukhorukov, Gleb B, Ivanov, Vladimir K

“…The design of novel, effective drug delivery systems is one of the most promising ways to improve the treatment of socially important diseases. This article…”
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Biodegradable Defined Shaped Printed Polymer Microcapsules for Drug Delivery by Kudryavtseva, Valeriya, Boi, Stefania, Read, Jordan, Guillemet, Raphael, Zhang, Jiaxin, Udalov, Andrei, Shesterikov, Evgeny, Tverdokhlebov, Sergei, Pastorino, Laura, Gould, David J, Sukhorukov, Gleb B

“…This work describes the preparation and characterization of printed biodegradable polymer (polylactic acid) capsules made in two different shapes: pyramid and…”
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In-situ NIR-laser mediated bioactive substance delivery to single cell for EGFP expression based on biocompatible microchamber-arrays by Gai, Meiyu, Kurochkin, Maxim A., Li, Danyang, Khlebtsov, Boris N., Dong, Luo, Tarakina, Nadja, Poston, Robin, Gould, David J., Frueh, Johannes, Sukhorukov, Gleb B.

“…Controlled drug delivery and gene expression is required for a large variety of applications including cancer therapy, wound healing, cell migration, cell…”
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Improved and targeted delivery of bioactive molecules to cells with magnetic layer-by-layer assembled microcapsules by Pavlov, Anton M, Gabriel, Samantha A, Sukhorukov, Gleb B, Gould, David J

“…Despite our increasing knowledge of cell biology and the recognition of an increasing repertoire of druggable intracellular therapeutic targets, there remain a…”
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Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production by Read, Jordan E, Luo, Dong, Chowdhury, Tina T, Flower, Rod J, Poston, Robin N, Sukhorukov, Gleb B, Gould, David J

“…Nanoengineered vehicles have the potential to deliver cargo drugs directly to disease sites, but can potentially be cleared by immune system cells or lymphatic…”
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Melting corneal ulcers (keratomalacia) in dogs: A 5‐year clinical and microbiological study (2014–2018) by Tsvetanova, Agata, Powell, Roger M., Tsvetanov, Kamen A., Smith, Kerry M., Gould, David J.

“…Objectives To identify bacterial microorganisms associated with canine keratomalacia, review their antimicrobial sensitivity, and evaluate clinical outcomes…”
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Investigation of the allele frequency of the G>A intron 10 ADAMTS17 mutation causing primary lens luxation in the Portuguese Podengo breed by Tzouganakis, Ioannis, Tsvetanova, Agata, Jeanes, Emily C., Mellersh, Cathryn S., Gould, David J.

“…Objective To establish the allele frequency of the PLL‐causing G>A intron 10 ADAMTS17 mutation in the Portuguese Podengo population in the UK and investigate a…”
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A comparison of CAT Doppler and oscillometric Memoprint machines for non-invasive blood pressure measurement in conscious cats by Jepson, Rosanne E., Hartley, Vivien, Mendl, Michael, Caney, Sarah M.E., Gould, David J.

“…Indirect blood pressure measurements were compared in 28 conscious cats using Doppler and oscillometric blood pressure-measuring devices. Ten cats were used to…”
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Electrospun poly(lactic acid) fibers containing novel chlorhexidine particles with sustained antibacterial activity by Luo, Dong, Zhang, Xi, Shahid, Saroash, Cattell, Michael J, Gould, David J, Sukhorukov, Gleb B

“…The treatment of persistent infections often requires a high local drug concentration and sustained release of antimicrobial agents. This paper proposes the…”
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Location of molecules in layer-by-layer assembled microcapsules influences activity, cell delivery and susceptibility to enzyme degradation by Pavlov, Anton M., Sukhorukov, Gleb B., Gould, David J

“…Layer-by-layer assembled microcapsules have the potential to be versatile cell delivery systems incorporating multiple activities and functions. However, it is…”
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Survey of the incidence of pectinate ligament dysplasia and glaucoma in the UK Leonberger population by Fricker, Georgina V., Smith, Kerry, Gould, David J.

“…Objective To determine the prevalence of pectinate ligament dysplasia (PLD) in UK Leonbergers and identify cases affected by glaucoma. Also, to define the…”
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immunohistochemical study of uveodermatologic syndrome in two Japanese Akita dogs by Carter, W.J, Crispin, S.M, Gould, D.J, Day, M.J

“…Materials Ocular and cutaneous tissues from two Japanese Akita dogs with uveodermatologic syndrome (UVD) were subjected to immunohistochemical analysis…”
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Lessons in Microcapsule Assembly from Imaging Delivery of a Bioluminescent Enzyme by Pavlov, Anton M, Sukhorukov, Gleb B, Gould, David J

“…Layer-by-layer assembled microcapsules have potential applications as delivery and biosensing systems, which make them attractive tools for use in various…”
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An ADAMTS17 splice donor site mutation in dogs with primary lens luxation by Farias, Fabiana H G, Johnson, Gary S, Taylor, Jeremy F, Giuliano, Elizabeth, Katz, Martin L, Sanders, Douglas N, Schnabel, Robert D, McKay, Stephanie D, Khan, Shahnawaz, Gharahkhani, Puya, O'Leary, Caroline A, Pettitt, Louise, Forman, Oliver P, Boursnell, Mike, McLaughlin, Bryan, Ahonen, Saija, Lohi, Hannes, Hernandez-Merino, Elena, Gould, David J, Sargan, David R, Mellersh, Cathryn

“…To identify the genetic cause of isolated canine ectopia lentis, a well-characterized veterinary disease commonly referred to as primary lens luxation (PLL)…”
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Validity of aqueocentesis as a component of anterior uveitis investigation in dogs and cats by Linn-Pearl, Rose N., Powell, Roger M., Newman, Hayley A., Gould, David J.

“…OBJECTIVE: To describe aqueocentesis cytopathology results from dogs and cats presenting for uveitis investigation and to determine whether this is a useful…”
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