Search Results - "Gould, Alex P."

Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila by Bailey, Andrew P., Koster, Grielof, Guillermier, Christelle, Hirst, Elizabeth M.A., MacRae, James I., Lechene, Claude P., Postle, Anthony D., Gould, Alex P.

“…Stem cells reside in specialized microenvironments known as niches. During Drosophila development, glial cells provide a niche that sustains the proliferation…”
Get full text

The sex of specific neurons controls female body growth in Drosophila by Sawala, Annick, Gould, Alex P

“…Sexual dimorphisms in body size are widespread throughout the animal kingdom but their underlying mechanisms are not well characterized. Most models for how…”
Get full text

Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila by Obata, Fumiaki, Fons, Clara O., Gould, Alex P.

“…Environmental stresses experienced during development exert many long-term effects upon health and disease. For example, chemical oxidants or genetic…”
Get full text

The Development and Functions of Oenocytes by Makki, Rami, Cinnamon, Einat, Gould, Alex P

“…Oenocytes have intrigued insect physiologists since the nineteenth century. Many years of careful but mostly descriptive research on these cells highlights…”
Get full text

Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila by Cheng, Louise Y., Bailey, Andrew P., Leevers, Sally J., Ragan, Timothy J., Driscoll, Paul C., Gould, Alex P.

“…Developing animals survive periods of starvation by protecting the growth of critical organs at the expense of other tissues. Here, we use Drosophila to…”
Get full text

Adipose triglyceride lipase protects renal cell endocytosis in a Drosophila dietary model of chronic kidney disease by Lubojemska, Aleksandra, Stefana, M Irina, Sorge, Sebastian, Bailey, Andrew P, Lampe, Lena, Yoshimura, Azumi, Burrell, Alana, Collinson, Lucy, Gould, Alex P

“…Obesity-related renal lipotoxicity and chronic kidney disease (CKD) are prevalent pathologies with complex aetiologies. One hallmark of renal lipotoxicity is…”
Get full text

Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism by Steinhauser, Matthew L., Bailey, Andrew P., Senyo, Samuel E., Guillermier, Christelle, Perlstein, Todd S., Gould, Alex P., Lee, Richard T., Lechene, Claude P.

“…Multi-isotope imaging mass spectrometry is used to investigate the ‘immortal strand hypothesis’, Drosophila lipid metabolism and human lymphopoiesis…”
Get full text

Specialized hepatocyte-like cells regulate Drosophila lipid metabolism by Fielding, Barbara, Wiggins, David, Gould, Alex P, Gutierrez, Eugenio

“…Lipid metabolism is essential for growth and generates much of the energy needed during periods of starvation. In Drosophila, fasting larvae release large…”
Get full text

Developmental diet regulates Drosophila lifespan via lipid autotoxins by Stefana, M. Irina, Driscoll, Paul C., Obata, Fumiaki, Pengelly, Ana Raquel, Newell, Clare L., MacRae, James I., Gould, Alex P.

“…Early-life nourishment exerts long-term influences upon adult physiology and disease risk. These lasting effects of diet are well established but the…”
Get full text

Cryogenic OrbiSIMS Localizes Semi‐Volatile Molecules in Biological Tissues by Newell, Clare L., Vorng, Jean‐Luc, MacRae, James I., Gilmore, Ian S., Gould, Alex P.

“…OrbiSIMS is a recently developed instrument for label‐free imaging of chemicals with micron spatial resolution and high mass resolution. We report a cryogenic…”
Get full text

Protection of Neuronal Diversity at the Expense of Neuronal Numbers during Nutrient Restriction in the Drosophila Visual System by Lanet, Elodie, Gould, Alex P., Maurange, Cédric

“…Systemic signals provided by nutrients and hormones are known to coordinate the growth and proliferation of different organs during development. However,…”
Get full text

Functions of Stress-Induced Lipid Droplets in the Nervous System by Islimye, Eva, Girard, Victor, Gould, Alex P

“…Lipid droplets are highly dynamic intracellular organelles that store neutral lipids such as cholesteryl esters and triacylglycerols. They have recently…”
Get full text

Postmitotic specification of Drosophila insulinergic neurons from pioneer neurons by Miguel-Aliaga, Irene, Thor, Stefan, Gould, Alex P

“…Insulin and related peptides play important and conserved functions in growth and metabolism. Although Drosophila has proved useful for the genetic analysis of…”
Get full text

Temporal control of neuronal diversity: common regulatory principles in insects and vertebrates? by Jacob, John, Maurange, Cédric, Gould, Alex P

“…It is well established in species as diverse as insects and mammals that different neuronal and glial subtypes are born at distinct times during central…”
Get full text

Lipid droplet functions beyond energy storage by Welte, Michael A., Gould, Alex P.

“…Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important for energy metabolism. Their function in energy storage is…”
Get full text

Sex-lethal in neurons controls female body growth in Drosophila by Sawala, Annick, Gould, Alex P.

“…Sexual size dimorphism (SSD), a sex difference in body size, is widespread throughout the animal kingdom, raising the question of how sex influences existing…”
Get full text

Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling by Cinnamon, Einat, Makki, Rami, Sawala, Annick, Wickenberg, Leah P, Blomquist, Gary J, Tittiger, Claus, Paroush, Ze'ev, Gould, Alex P

“…Cell growth and proliferation depend upon many different aspects of lipid metabolism. One key signaling pathway that is utilized in many different anabolic…”
Get full text

Drosophila Grainyhead specifies late programmes of neural proliferation by regulating the mitotic activity and Hox-dependent apoptosis of neuroblasts by Cenci, Caterina, Gould, Alex P

“…The Drosophila central nervous system is generated by stem-cell-like progenitors called neuroblasts. Early in development, neuroblasts switch through a…”
Get full text

Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism by Breckenridge, Ross A, Piotrowska, Izabela, Ng, Keat-Eng, Ragan, Timothy J, West, James A, Kotecha, Surendra, Towers, Norma, Bennett, Michael, Kienesberger, Petra C, Smolenski, Ryszard T, Siddall, Hillary K, Offer, John L, Mocanu, Mihaela M, Yelon, Derek M, Dyck, Jason R B, Griffin, Jules L, Abramov, Andrey Y, Gould, Alex P, Mohun, Timothy J

“…Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is…”
Get full text

Quantification of fetal organ sparing in maternal low-protein dietary models by Serpente, Patricia, Zhang, Ying, Islimye, Eva, Hart-Johnson, Sarah, Gould, Alex P

“…Maternal malnutrition can lead to fetal growth restriction. This is often associated with organ sparing and long-lasting physiological dysfunctions during…”
Get full text