Search Results - "Gouin, Sébastien G"

Multivalent Inhibitors for Carbohydrate-Processing Enzymes: Beyond the "Lock-and-Key" Concept by Gouin, Sébastien G.

“…During the last decades, tremendous chemical efforts have been dedicated to design monovalent inhibitors of carbohydrate‐processing enzymes, with comparatively…”
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Tyrosine Conjugation Methods for Protein Labelling by Alvarez Dorta, Dimitri, Deniaud, David, Mével, Mathieu, Gouin, Sébastien G.

“…Over the last two decades, the development of chemical biology and the need for more defined protein conjugates have fostered active research on new…”
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Electrochemically Promoted Tyrosine-Click-Chemistry for Protein Labeling by Alvarez-Dorta, Dimitri, Thobie-Gautier, Christine, Croyal, Mikael, Bouzelha, Mohammed, Mével, Mathieu, Deniaud, David, Boujtita, Mohammed, Gouin, Sébastien G

“…The development of new bio-orthogonal ligation methods for the conjugation of native proteins is of particular importance in the field of chemical biology and…”
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Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands by Deniaud, David, Julienne, Karine, Gouin, Sébastien G

“…Much effort has been made during the last decade to design lectin inhibitors as therapeutics against viral and bacterial adhesion or to control biological…”
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Click-electrochemistry for the rapid labeling of virus, bacteria and cell surfaces by Depienne, Sébastien, Bouzelha, Mohammed, Courtois, Emmanuelle, Pavageau, Karine, Lalys, Pierre-Alban, Marchand, Maia, Alvarez-Dorta, Dimitri, Nedellec, Steven, Marín-Fernández, Laura, Grandjean, Cyrille, Boujtita, Mohammed, Deniaud, David, Mével, Mathieu, Gouin, Sébastien G.

“…Methods for direct covalent ligation of microorganism surfaces remain poorly reported, and mostly based on metabolic engineering for bacteria and cells…”
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Luminol anchors improve the electrochemical-tyrosine-click labelling of proteins by Depienne, Sébastien, Alvarez-Dorta, Dimitri, Croyal, Mikael, Temgoua, Ranil C. T, Charlier, Cathy, Deniaud, David, Mével, Mathieu, Boujtita, Mohammed, Gouin, Sébastien G

“…New methods for chemo-selective modifications of peptides and native proteins are important in chemical biology and for the development of therapeutic…”
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Recent advances in cancer treatment by iron chelators by Corcé, Vincent, Gouin, Sébastien G., Renaud, Stéphanie, Gaboriau, François, Deniaud, David

“…[Display omitted] The development of new therapeutic alternatives for cancers is a major public health priority. Among the more promising approaches, the iron…”
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Multivalency To Inhibit and Discriminate Hexosaminidases by Alvarez‐Dorta, Dimitri, King, Dustin T., Legigan, Thibaut, Ide, Daisuke, Adachi, Isao, Deniaud, David, Désiré, Jérôme, Kato, Atsushi, Vocadlo, David, Gouin, Sébastien G., Blériot, Yves

“…A set of multivalent polyhydroxylated acetamidoazepanes based on ethylene glycol, glucoside, or cyclodextrin scaffolds was prepared. The compounds were…”
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Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases by Brissonnet, Yoan, Ortiz Mellet, Carmen, Morandat, Sandrine, Garcia Moreno, M. Isabel, Deniaud, David, Matthews, Susan E, Vidal, Sébastien, Šesták, Sergej, El Kirat, Karim, Gouin, Sébastien G

“…Multivalent iminosugars have been recently explored for glycosidase inhibition. Affinity enhancements due to multivalency have been reported for specific…”
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Multivalent Fucosides with Nanomolar Affinity for the Aspergillus fumigatus Lectin FleA Prevent Spore Adhesion to Pneumocytes by Lehot, Victor, Brissonnet, Yoan, Dussouy, Christophe, Brument, Sami, Cabanettes, Aurore, Gillon, Emilie, Deniaud, David, Varrot, Annabelle, Le Pape, Patrice, Gouin, Sébastien G.

“…FleA (or AFL), a fucose lectin, was recently identified in the opportunistic mold Aspergillus fumigatus, which causes fatal lung infections in…”
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Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts by Yang, Hyungjun, Mirsepasi-Lauridsen, Hengameh Chloé, Struve, Carsten, Allaire, Joannie M., Sivignon, Adeline, Vogl, Wayne, Bosman, Else S., Ma, Caixia, Fotovati, Abbas, Reid, Gregor S., Li, Xiaoxia, Petersen, Andreas Munk, Gouin, Sébastien G., Barnich, Nicolas, Jacobson, Kevan, Yu, Hong Bing, Krogfelt, Karen Angeliki, Vallance, Bruce A.

“…Ulcerative colitis (UC) is a chronic inflammatory condition linked to intestinal microbial dysbiosis, including the expansion of E. coli strains related to…”
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Chemical modification of the adeno-associated virus capsid to improve gene delivery by Mével, Mathieu, Bouzelha, Mohammed, Leray, Aurélien, Pacouret, Simon, Guilbaud, Mickael, Penaud-Budloo, Magalie, Alvarez-Dorta, Dimitri, Dubreil, Laurence, Gouin, Sébastien G., Combal, Jean Philippe, Hommel, Mirja, Gonzalez-Aseguinolaza, Gloria, Blouin, Véronique, Moullier, Philippe, Adjali, Oumeya, Deniaud, David, Ayuso, Eduard

“…Gene delivery vectors based on adeno-associated virus (AAV) are highly promising due to several desirable features of this parent virus, including a lack of…”
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Polyvalent Transition‐State Analogues of Sialyl Substrates Strongly Inhibit Bacterial Sialidases by Assailly, Coralie, Bridot, Clarisse, Saumonneau, Amélie, Lottin, Paul, Roubinet, Benoit, Krammer, Eva‐Maria, François, Francesca, Vena, Federica, Landemarre, Ludovic, Alvarez Dorta, Dimitri, Deniaud, David, Grandjean, Cyrille, Tellier, Charles, Pascual, Sagrario, Montembault, Véronique, Fontaine, Laurent, Daligault, Franck, Bouckaert, Julie, Gouin, Sébastien G.

“…Bacterial sialidases (SA) are validated drug targets expressed by common human pathogens such as Streptococcus pneumoniae, Vibrio cholerae, or Clostridium…”
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Polymeric Iminosugars Improve the Activity of Carbohydrate-Processing Enzymes by Brissonnet, Yoan, Ladevèze, Simon, Tezé, David, Fabre, Emeline, Deniaud, David, Daligault, Franck, Tellier, Charles, Šesták, Sergej, Remaud-Simeon, Magali, Potocki-Veronese, Gabrielle, Gouin, Sébastien G

“…Multivalent iminosugars have recently emerged as powerful tools to inhibit the activities of specific glycosidases. In this work, biocompatible dextrans were…”
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Thiazolylaminomannosides As Potent Antiadhesives of Type 1 Piliated Escherichia coli Isolated from Crohn’s Disease Patients by Brument, Sami, Sivignon, Adeline, Dumych, Tetiana I, Moreau, Nicolas, Roos, Goedele, Guérardel, Yann, Chalopin, Thibaut, Deniaud, David, Bilyy, Rostyslav O, Darfeuille-Michaud, Arlette, Bouckaert, Julie, Gouin, Sébastien G

“…Adherent-invasive Escherichia coli (AIEC) have previously been shown to induce gut inflammation in patients with Crohn’s disease (CD). We developed a set of…”
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Glycopolymers as Antiadhesives of E. coli Strains Inducing Inflammatory Bowel Diseases by Yan, Xibo, Sivignon, Adeline, Yamakawa, Nao, Crepet, Agnes, Travelet, Christophe, Borsali, Redouane, Dumych, Tetiana, Li, Zhaoli, Bilyy, Rostyslav, Deniaud, David, Fleury, Etienne, Barnich, Nicolas, Darfeuille-Michaud, Arlette, Gouin, Sébastien G, Bouckaert, Julie, Bernard, Julien

“…n-Heptyl α-d-mannose (HM) is a nanomolar antagonist of FimH, a virulence factor of E. coli. Herein we report on the construction of multivalent HM-based…”
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ROMP-based Glycopolymers with High Affinity for Mannose-Binding Lectins by Gonnot, Clément, Scalabrini, Mathieu, Roubinet, Benoit, Ziane, Célia, Boeda, Fabien, Deniaud, David, Landemarre, Ludovic, Gouin, Sébastien G., Fontaine, Laurent, Montembault, Véronique

“…Well-defined, highly reactive poly­(norbornenyl azlactone)­s of controlled length (number-average degree of polymerization D P n ̅ = 10 to 1,000) were made by…”
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Multivalent inhibition of the Aspergillus fumigatus KDNase by Scalabrini, Mathieu, Loquet, Denis, Rochard, Camille, Baudin Marie, Mélyne, Assailly, Coralie, Brissonnet, Yoan, Daligault, Franck, Saumonneau, Amélie, Lambert, Annie, Grandjean, Cyrille, Deniaud, David, Lottin, Paul, Pascual, Sagrario, Fontaine, Laurent, Balloy, Viviane, Gouin, Sébastien G

“…is a saprophytic fungus and opportunistic pathogen often causing fatal infections in immunocompromised patients. Recently KDNAse, an exoglycosidase hydrolyzing…”
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Clustering of Escherichia coli Type-1 Fimbrial Adhesins by Using Multimeric Heptyl α-D-Mannoside Probes with a Carbohydrate Core by Almant, Mehdi, Moreau, Vincent, Kovensky, José, Bouckaert, Julie, Gouin, Sébastien G.

“…Heptyl α‐D‐mannoside (HM) is a strong inhibitor of the FimH lectin that mediates the initial adhesion of the uropathogenic Escherichia coli (E. coli) to the…”
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Novel chemical tyrosine functionalization of adeno-associated virus improves gene transfer efficiency in liver and retina by Leray, Aurélien, Lalys, Pierre-Alban, Varin, Juliette, Bouzelha, Mohammed, Bourdon, Audrey, Alvarez-Dorta, Dimitri, Pavageau, Karine, Depienne, Sébastien, Marchand, Maia, Mellet, Anthony, Demilly, Joanna, Ducloyer, Jean-Baptiste, Girard, Tiphaine, Fraysse, Bodvaël, Ledevin, Mireille, Guilbaud, Mickaël, Gouin, Sébastien G., Ayuso, Eduard, Adjali, Oumeya, Larcher, Thibaut, Cronin, Thérèse, Le Guiner, Caroline, Deniaud, David, Mével, Mathieu

“…Decades of biological and clinical research have led to important advances in recombinant adeno-associated viruses rAAV-based gene therapy gene therapy…”
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