Search Results - "Gough, Kathleen M"

Orientation Matters: Polarization Dependent IR Spectroscopy of Collagen from Intact Tendon Down to the Single Fibril Level by Bakir, Gorkem, Girouard, Benoit E, Wiens, Richard, Mastel, Stefan, Dillon, Eoghan, Kansiz, Mustafa, Gough, Kathleen M

“…Infrared (IR) spectroscopy has been used for decades to study collagen in mammalian tissues. While many changes in the spectral profiles appear under polarized…”
Get full text

Synchrotron FTIR reveals lipid around and within amyloid plaques in transgenic mice and Alzheimer's disease brain by Liao, Catherine R, Rak, Margaret, Lund, Jillian, Unger, Miriam, Platt, Eric, Albensi, Benedict C, Hirschmugl, Carol J, Gough, Kathleen M

“…While the basis of neuronal degeneration in Alzheimer's disease (AD) continues to be debated, the amyloid cascade hypothesis remains central. Amyloid plaques…”
Get more information

Carbon and nitrogen uptake rates and macromolecular compositions of bottom-ice algae and phytoplankton at Cambridge Bay in Dease Strait, Canada by Kim, Kwanwoo, Ha, Sun-Yong, Kim, Bo Kyung, Mundy, C. J., Gough, Kathleen M., Pogorzelec, Nicole M., Lee, Sang Heon

“…Our understanding of ice algal responses to the recent changes in Arctic sea ice is impeded by limited field observations. In the present study, environmental…”
Get full text

High spatial resolution (1.1 μm and 20 nm) FTIR polarization contrast imaging reveals pre-rupture disorder in damaged tendon by Wiens, Richard, Findlay, Catherine R, Baldwin, Samuel G, Kreplak, Laurent, Lee, J Michael, Veres, Samuel P, Gough, Kathleen M

“…Collagen is a major constituent in many life forms; in mammals, collagen appears as a component of skin, bone, tendon and cartilage, where it performs critical…”
Get more information

Focally Elevated Creatine Detected in Amyloid Precursor Protein (APP) Transgenic Mice and Alzheimer Disease Brain Tissue by Gallant, Meghan, Rak, Margaret, Szeghalmi, Adriana, Del Bigio, Marc R., Westaway, David, Yang, Jin, Julian, Robert, Gough, Kathleen M.

“…The creatine/phosphocreatine system, regulated by creatine kinase, plays an important role in maintaining energy balance in the brain. Energy metabolism and…”
Get full text

Fourier Transform Infrared Spectrochemical Imaging: Review of Design and Applications with a Focal Plane Array and Multiple Beam Synchrotron Radiation Source by Hirschmugl, Carol J., Gough, Kathleen M.

“…The beamline design, microscope specifications, and initial results from the new mid-infrared beamline (IRENI) are reviewed. Synchrotron-based spectrochemical…”
Get full text

Spectropathology for the next generation: quo vadis? by Byrne, Hugh J, Baranska, Malgorzata, Puppels, Gerwin J, Stone, Nick, Wood, Bayden, Gough, Kathleen M, Lasch, Peter, Heraud, Phil, Sulé-Suso, Josep, Sockalingum, Ganesh D

“…Although the potential of vibrational spectroscopy for biomedical applications has been well demonstrated, translation into clinical practice has been…”
Get more information

Widefield Super-Resolution Infrared Spectroscopy and Imaging of Autofluorescent Biological Materials and Photosynthetic Microorganisms Using Fluorescence Detected Photothermal Infrared (FL-PTIR) by Prater, Craig B, Kjoller, Kevin J, Stuart, Andrew P D, Grigg, David A, 'Limurn, Rinuk, Gough, Kathleen M

“…We have demonstrated high-speed, super-resolution infrared (IR) spectroscopy and chemical imaging of autofluorescent biomaterials and organisms using…”
Get full text

Characterization of mannitol in Curvularia protuberata hyphae by FTIR and Raman spectromicroscopy by Isenor, Merrill, Kaminskyj, Susan G W, Rodriguez, Russell J, Redman, Regina S, Gough, Kathleen M

“…FTIR and Raman spectromicroscopy were used to characterize the composition of Curvularia protuberata hyphae, and to compare a strain isolated from plants…”
Get more information

Optical diagnosis - highlighting the clinical applications of vibrational spectroscopy by Gough, Kathleen M, Leblond, Frédéric

Get more information

Saccharomyces cerevisiae CellWall Remodeling in the Absence of Knr4 and Kre6 Revealed by Nano-FourierTransform Infrared Spectroscopy by Bakir, Gorkem, Dahms, Tanya E. S., Martin-Yken, Helene, Bechtel, Hans A., Gough, Kathleen M.

“…The cell wall integrity (CWI) signaling pathway regulates yeast cell wall biosynthesis, cell division, and responses to external stress. The cell wall,…”
Get full text

Near-field infrared nanospectroscopy and super-resolution fluorescence microscopy enable complementary nanoscale analyses of lymphocyte nuclei by Ajaezi, Godwin C, Eisele, Max, Contu, Fabio, Lal, Sadhana, Rangel-Pozzo, Aline, Mai, Sabine, Gough, Kathleen M

“…Recent super-resolution fluorescence microscopy (3D-Structured Illumination Microscopy, 3D-SIM) studies have revealed significantly altered nuclear…”
Get more information

synchrotron FTIR microspectroscopy investigation of fungal hyphae grown under optimal and stressed conditions by Szeghalmi, Adriana, Kaminskyj, Susan, Gough, Kathleen M

“…Synchrotron FTIR can provide high spatial resolution (<10 μm pixel size) in situ biochemical analyses of intact biotissues, an area of increasing importance in…”
Get full text

The Art of the Loop: Analogy, Aurality, History, Performance by Gough, Kathleen M.

“…The dramaturgical aesthetic of recent postdramatic performance returns to medieval representational modes: an eye can be used as an ear, and vision can be…”
Get full text

Restoration and Spectral Recovery of Mid-Infrared Chemical Images by Mattson, Eric C, Nasse, Michael J, Rak, Margaret, Gough, Kathleen M, Hirschmugl, Carol J

“…Fourier transform infrared (FTIR) microspectroscopy is a powerful technique for label-free chemical imaging that has supplied important chemical information…”
Get full text

FTIR imaging analysis of cell content in sea-ice diatom taxa during a spring bloom in the lower Northwest Passage of the Canadian Arctic by Pogorzelec, Nicole M., Mundy, C. J., Findlay, Catherine R., Campbell, Karley, Diaz, Aura, Ehn, Jens K., Rysgaard, Søren, Gough, Kathleen M.

“…During their vernal bloom, ice algae respond to variable light and nutrient availability by changing their production of cellular lipids and proteins. Fourier…”
Get full text

FTIR autecological analysis of bottom-ice diatom taxa across a tidal strait in the Canadian Arctic by Pogorzelec, Nicole M., Gough, Kathleen M., Ha, Sun-Yong, Campbell, Karley, Else, Brent, Kim, Kwanwoo, Lee, Sang Heon, Mundy, C. J.

“…A recent study demonstrated that an Arctic tidal strait, where a shoaled and constricted waterway increases tidally driven sub-ice currents and turbulence,…”
Get full text

Association among Amyloid Plaque, Lipid, and Creatine in Hippocampus of TgCRND8 Mouse Model for Alzheimer Disease by Kuzyk, Alexandra, Kastyak, Marzena, Agrawal, Veena, Gallant, Meghan, Sivakumar, Gajjeraman, Rak, Margaret, Del Bigio, Marc R., Westaway, David, Julian, Robert, Gough, Kathleen M.

“…Amyloid peptide (Aβ) aggregation in the brain is a characteristic feature of Alzheimer disease (AD). Previously, we reported the discovery of focally elevated…”
Get full text

Time Fluctuations and Imaging in the SERS Spectra of Fungal Hypha Grown on Nanostructured Substrates by Szeghalmi, Adriana, Kaminskyj, Susan, Rösch, Petra, Popp, Jürgen, Gough, Kathleen M

“…Surface-enhanced Raman scattering (SERS) spectroscopy is an emerging technique in biomolecular analysis that can have a tremendous impact in the life sciences…”
Get full text

X-ray microfluorescence (μXRF) imaging of Aspergillus nidulans cell wall mutants reveals biochemical changes due to gene deletions by Rak, Margaret, Salome, Murielle, Kaminskyj, Susan G. W., Gough, Kathleen M.

“…We used synchrotron X-ray fluorescence to create the first semiquantitative, submicron resolution, element distribution maps of P, S, K, and Ca, in situ, in…”
Get full text