Search Results - "Gough, Daniel J."

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling by Gough, Daniel J., Messina, Nicole L., Clarke, Christopher J.P., Johnstone, Ricky W., Levy, David E.

“…Interferons (IFNs) were discovered as cytokines induced during and protecting from viral infection. They have been documented to play essential roles in…”
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The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation by Gough, Daniel J, Koetz, Lisa, Levy, David E

“…Activating mutations in the RasGTPases are the most common oncogenic lesions in human cancer. Similarly, elevated STAT3 expression and/or phosphorylation are…”
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The JAK/STAT pathway in obesity and diabetes by Gurzov, Esteban N., Stanley, William J., Pappas, Evan G., Thomas, Helen E., Gough, Daniel J.

“…Diabetes mellitus are complex, multi‐organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent…”
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Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation by Gough, Daniel J, Corlett, Alicia, Schlessinger, Karni, Wegrzyn, Joanna, Larner, Andrew C, Levy, David E

“…Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor responsive to cytokine signaling and tyrosine kinase…”
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression by Balic, Jesse J., Albargy, Hassan, Luu, Kevin, Kirby, Francis J., Jayasekara, W. Samantha N., Mansell, Finbar, Garama, Daniel J., De Nardo, Dominic, Baschuk, Nikola, Louis, Cynthia, Humphries, Fiachra, Fitzgerald, Katherine, Latz, Eicke, Gough, Daniel J., Mansell, Ashley

“…Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a robust pro-inflammatory response…”
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Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages by Dowling, Jennifer K., Afzal, Remsha, Gearing, Linden J., Cervantes-Silva, Mariana P., Annett, Stephanie, Davis, Gavin M., De Santi, Chiara, Assmann, Nadine, Dettmer, Katja, Gough, Daniel J., Bantug, Glenn R., Hamid, Fidinny I., Nally, Frances K., Duffy, Conor P., Gorman, Aoife L., Liddicoat, Alex M., Lavelle, Ed C., Hess, Christoph, Oefner, Peter J., Finlay, David K., Davey, Gavin P., Robson, Tracy, Curtis, Annie M., Hertzog, Paul J., Williams, Bryan R. G., McCoy, Claire E.

“…Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10)…”
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MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat by Chen, Jasmine, Guanizo, Aleks C, Jakasekara, W Samantha N, Inampudi, Chaitanya, Luong, Quinton, Garama, Daniel J, Alamgeer, Muhammad, Thakur, Nishant, DeVeer, Michael, Ganju, Vinod, Watkins, D Neil, Cain, Jason E, Gough, Daniel J

“…Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer with an appalling overall survival of less than 5% (Zimmerman et al. J Thor Oncol…”
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Serine-Phosphorylated STAT3 Promotes Tumorigenesis via Modulation of RNA Polymerase Transcriptional Activity by Balic, Jesse J, Garama, Daniel J, Saad, Mohamed I, Yu, Liang, West, Alison C, West, Alice J, Livis, Thaleia, Bhathal, Prithi S, Gough, Daniel J, Jenkins, Brendan J

“…Deregulated activation of the latent oncogenic transcription factor STAT3 in many human epithelial malignancies, including gastric cancer, has invariably been…”
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STAT3 supports experimental K-RasG12D–induced murine myeloproliferative neoplasms dependent on serine phosphorylation by Gough, Daniel J., Marié, Isabelle J., Lobry, Camille, Aifantis, Iannis, Levy, David E.

“…Juvenile myelomonocytic leukemia, acute myeloid leukemia (AML), and other myeloproliferative neoplasms (MPNs) are genetically heterogeneous but frequently…”
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A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3 by Garama, Daniel J., Harris, Tiffany J., White, Christine L., Rossello, Fernando J., Abdul-Hay, Maher, Gough, Daniel J., Levy, David E.

“…Increased production of mitochondrion-derived reactive oxygen species (ROS) is characteristic of a metabolic shift observed during malignant transformation…”
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Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling by Cochrane, Catherine R, Vaghjiani, Vijesh, Szczepny, Anette, Jayasekara, W Samantha N, Gonzalez-Rajal, Alvaro, Kikuchi, Kazu, McCaughan, Geoffrey W, Burgess, Andrew, Gough, Daniel J, Watkins, D Neil, Cain, Jason E

“…Ligand-dependent activation of Hedgehog (Hh) signaling in cancer occurs without mutations in canonical pathway genes. Consequently, the genetic basis of Hh…”
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Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease by Balic, Jesse J., Saad, Mohamed I., Dawson, Ruby, West, Alice J., McLeod, Louise, West, Alison C., D'Costa, Kimberley, Deswaerte, Virginie, Dev, Anouk, Sievert, William, Gough, Daniel J., Bhathal, Prithi S., Ferrero, Richard L., Jenkins, Brendan J.

“…Gastric cancer is associated with chronic inflammation (gastritis) triggered by persistent Helicobacter pylori (H. pylori) infection. Elevated tyrosine…”
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Functional crosstalk between type I and II interferon through the regulated expression of STAT1 by Gough, Daniel J, Messina, Nicole L, Hii, Linda, Gould, Jodee A, Sabapathy, Kanaga, Robertson, Ashley P S, Trapani, Joseph A, Levy, David E, Hertzog, Paul J, Clarke, Christopher J P, Johnstone, Ricky W

“…Autocrine priming of cells by small quantities of constitutively produced type I interferon (IFN) is a well-known phenomenon. In the absence of type I IFN…”
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A STAT3 protein complex required for mitochondrial mRNA stability and cancer by Fernando, C. Dilanka, Jayasekara, W. Samantha N., Inampudi, Chaitanya, Kohonen-Corish, Maija R.J., Cooper, Wendy A., Beilharz, Traude H., Josephs, Tracy M., Garama, Daniel J., Gough, Daniel J.

“…Signal transducer and activator of transcription 3 (STAT3) is a potent transcription factor necessary for life whose activity is corrupted in diverse diseases,…”
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A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma by White, Christine L, Jayasekara, W Samantha N, Picard, Daniel, Chen, Jasmine, Watkins, D Neil, Cain, Jason E, Remke, Marc, Gough, Daniel J

“…Medulloblastoma is the most common malignant brain tumor in children and represents 20% of all pediatric central nervous system neoplasms. While advances in…”
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Mitochondrial STAT3 Supports RasDependent Oncogenic Transformation by GOUGH, Daniel J, CORLETT, Alicia, SCHIESSINGER, Karni, WEGRZYN, Joanna, LEARNER, Andrew C, LEVY, David E

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STAT3: a multifaceted oncoprotein by Guanizo, Aleks C., Fernando, Chamira Dilanka, Garama, Daniel J., Gough, Daniel J.

“…Signal transducer and activator of transcription (STAT) 3 is a key signalling protein engaged by a multitude of growth factors and cytokines to elicit diverse…”
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IFNγ signaling—Does it mean JAK–STAT? by Gough, Daniel J, Levy, David E, Johnstone, Ricky W, Clarke, Christopher J

“…Abstract The molecular pathways involved in the cellular response to interferon (IFN)γ have been the focus of much research effort due to their importance in…”
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Mitochondrial STAT3: Powering up a potent factor by Garama, Daniel J., White, Christine L., Balic, Jesse J., Gough, Daniel J.

“…The JAK-STAT3 signaling pathway is engaged by many cytokines and growth factor stimuli to control diverse biological processes including proliferation,…”
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MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase by Sooraj, Dhanya, Sun, Claire, Doan, Anh, Garama, Daniel J., Dannappel, Marius V., Zhu, Danxi, Chua, Hui K., Mahara, Sylvia, Wan Hassan, Wan Amir, Tay, Yeng Kwang, Guanizo, Aleks, Croagh, Daniel, Prodanovic, Zdenka, Gough, Daniel J., Wan, Chunhua, Firestein, Ron

“…Mediator kinases (CDK8/19) are transcriptional regulators broadly implicated in cancer. Despite their central role in fine-tuning gene-expression programs, we…”
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