Search Results - "Gouget, Hélène"

UPLC–MS/MS method for the simultaneous quantification of bictegravir and 13 others antiretroviral drugs plus cobicistat and ritonavir boosters in human plasma by Gouget, Hélène, Noé, Gaëlle, Barrail-Tran, Aurélie, Furlan, Valérie

“…•New quantification method for 13 antiretroviral drugs with most recent bictegravir and two booster cobicistat and ritonavir.•Sensitive and rapid ultra-high…”
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Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells by Passaes, Caroline, Desjardins, Delphine, Chapel, Anaïs, Monceaux, Valérie, Lemaitre, Julien, Mélard, Adeline, Perdomo-Celis, Federico, Planchais, Cyril, Gourvès, Maël, Dimant, Nastasia, David, Annie, Dereuddre-Bosquet, Nathalie, Barrail-Tran, Aurélie, Gouget, Hélène, Guillaume, Céline, Relouzat, Francis, Lambotte, Olivier, Guedj, Jérémie, Müller-Trutwin, Michaela, Mouquet, Hugo, Rouzioux, Christine, Avettand-Fenoël, Véronique, Le Grand, Roger, Sáez-Cirión, Asier

“…HIV remission can be achieved in some people, called post-treatment HIV controllers, after antiretroviral treatment discontinuation. Treatment initiation close…”
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Pharmacokinetics and tissue distribution of tenofovir, emtricitabine and dolutegravir in mice by Labarthe, Laura, Gelé, Thibaut, Gouget, Hélène, Benzemrane, Mariam-Sarah, Le Calvez, Pauline, Legrand, Nicolas, Lambotte, Olivier, Le Grand, Roger, Bourgeois, Christine, Barrail-Tran, Aurélie

“…Abstract Background Studies of antiretroviral drug (ARV) tissue distribution in preclinical models, such as mice, are key to understanding viral persistence…”
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Whole-body distribution of tenofovir, emtricitabine and dolutegravir in non-human primates by Gelé, Thibaut, Gouget, Hélène, Dimant, Nastasia, Furlan, Valérie, Collins, Jon, Scholz, Erin M B, Parry, Chris M, Le Grand, Roger, Lambotte, Olivier, Desjardins, Delphine, Barrail-Tran, Aurélie

“…Abstract Background One major barrier to HIV cure is the persistence of virus, possibly linked to an insufficient antiretroviral drug (ARV) distribution into…”
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Characteristics of Dolutegravir and Bictegravir Plasma Protein Binding: a First Approach for the Study of Pharmacologic Sanctuaries by Gelé, Thibaut, Gouget, Hélène, Furlan, Valérie, Becker, Pierre-Hadrien, Taburet, Anne-Marie, Lambotte, Olivier, Barrail-Tran, Aurélie

“…This study aimed to characterize dolutegravir (DTG) and bictegravir (BIC) binding. They had a preferential binding to human serum albumin (HSA) with two…”
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Cerebrospinal fluid exposure to bictegravir/emtricitabine/tenofovir in HIV-1-infected patients with CNS impairment by Gelé, Thibaut, Chéret, Antoine, Castro Gordon, Alicia, Nkam, Lionelle, Furlan, Valérie, Pallier, Coralie, Becker, Pierre-Hadrien, Catalan, Pilartxo, Goujard, Cécile, Taburet, Anne-Marie, Gasnault, Jacques, Gouget, Hélène, Barrail-Tran, Aurélie

“…Abstract Objectives The penetration of antiretroviral drugs into deep compartments, such as the CNS, is a crucial component of strategies towards an HIV cure…”
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Preclinical development and pharmacokinetic assessment in macaques of a multipurpose long-acting injectable suspension containing medroxyprogesterone acetate for contraception and rilpivirine for HIV prevention by Haeck, Clément M., Boyd, Peter, Dimant, Nastasia, Barrail-Tran, Aurélie, Gouget, Hélène, Le Grand, Roger, Desjardins, Delphine, Malcolm, R. Karl

“…Depot injections comprising aqueous drug suspensions are widely marketed for long-acting administration of contraceptive progestins and antipsychotics. In…”
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Pharmacological Validation of Long-Term Treatment with Antiretroviral Drugs in a Model of SIV-Infected Non-Human Primates by Gelé, Thibaut, Gouget, Hélène, Dereuddre-Bosquet, Nathalie, Furlan, Valérie, Le Grand, Roger, Lambotte, Olivier, Desjardins, Delphine, Barrail-Tran, Aurélie

“…The development of animal models undergoing long-term antiretroviral treatment (ART) makes it possible to understand a number of immunological, virological,…”
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