Search Results - "Gouda, Ahmed M"

Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism by Abourehab, Mohammed A S, Alqahtani, Alaa M, Youssif, Bahaa G M, Gouda, Ahmed M

“…Targeting the EGFR with small-molecule inhibitors is a confirmed valid strategy in cancer therapy. Since the FDA approval of the first EGFR-TKI, erlotinib,…”
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A Comprehensive Overview of Globally Approved JAK Inhibitors by Shawky, Ahmed M, Almalki, Faisal A, Abdalla, Ashraf N, Abdelazeem, Ahmed H, Gouda, Ahmed M

“…Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce…”
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Icotinib, Almonertinib, and Olmutinib: A 2D Similarity/Docking-Based Study to Predict the Potential Binding Modes and Interactions into EGFR by Almalki, Faisal A, Shawky, Ahmed M, Abdalla, Ashraf N, Gouda, Ahmed M

“…In the current study, a 2D similarity/docking-based study was used to predict the potential binding modes of icotinib, almonertinib, and olmutinib into EGFR…”
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Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities by Shawky, Ahmed M., Ibrahim, Nashwa A., Abourehab, Mohammed A. S., Abdalla, Ashraf N., Gouda, Ahmed M.

“…In the current study, virtual screening of a small library of 1302 pyrrolizines bearing urea/thiourea moieties was performed. The top-scoring hits were…”
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Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives by Shaykoon, Montaser Sh, Marzouk, Adel A., Soltan, Osama M., Wanas, Amira S., Radwan, Mohamed M., Gouda, Ahmed M., Youssif, Bahaa G.M., Abdel-Aziz, Mohamed

“…[Display omitted] •Two series of 1,2,4-triazole and 1,3,4-oxadiazole derivatives were designed and synthesized.•3a-b and 4a-b showed higher antitrypanosomal…”
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Synergistic Anti Leukemia Effect of a Novel Hsp90 and a Pan Cyclin Dependent Kinase Inhibitors by Abdalla, Ashraf N, Abdallah, Mohamed E, Aslam, Akhmed, Bader, Ammar, Vassallo, Antonio, Tommasi, Nunziatina De, Malki, Waleed H, Gouda, Ahmed M, Mukhtar, Mohammed H, El-Readi, Mahmoud Zaki, Alkahtani, Hamad M, Abdel-Aziz, Alaa A-M, El-Azab, Adel S

“…Acute myeloid leukemia (AML) is among the top four malignancies in Saudi nationals, and it is the top leukemia subtype worldwide. Resistance to available AML…”
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In Silico Approach Using Free Software to Optimize the Antiproliferative Activity and Predict the Potential Mechanism of Action of Pyrrolizine-Based Schiff Bases by Almalki, Faisal A., Abdalla, Ashraf N., Shawky, Ahmed M., El Hassab, Mahmoud A., Gouda, Ahmed M.

“…In the current study, a simple in silico approach using free software was used with the experimental studies to optimize the antiproliferative activity and…”
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Pyrrolizine/Indolizine-NSAID Hybrids: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies by Abourehab, Mohammed A S, Alqahtani, Alaa M, Almalki, Faisal A, Zaher, Dana M, Abdalla, Ashraf N, Gouda, Ahmed M, Beshr, Eman A M

“…In the current study, eight new hybrids of the NSAIDs, ibuprofen and ketoprofen with five pyrrolizine/indolizine derivatives were designed and synthesized. The…”
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Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents by Shawky, Ahmed M., Ibrahim, Nashwa A., Abdalla, Ashraf N., Abourehab, Mohammed A. S., Gouda, Ahmed M.

“…In the present study, two new series of pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety were designed, synthesised, and evaluated for their cytotoxic…”
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Carprofen: a theoretical mechanistic study to investigate the impact of hydrophobic interactions of alkyl groups on modulation of COX-1/2 binding selectivity by Gouda, Ahmed M., Almalki, Faisal A.

“…Development of selective COX-1 and COX-2 was successfully used to overcome GIT side effects of the classical NSAIDs. Currently, virtual screening and docking…”
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Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities by Gouda, Ahmed M., Abdelazeem, Ahmed H., Abdalla, Ashraf N., Ahmed, Muhammad

“…Towards optimization of the pyrrolizine-5-carboxamide scaffold, a novel series of six derivatives ( and ) was prepared and evaluated for their…”
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Computational Analysis of Deleterious SNPs in NRAS to Assess Their Potential Correlation With Carcinogenesis by Behairy, Mohammed Y., Soltan, Mohamed A., Adam, Mohamed S., Refaat, Ahmed M., Ezz, Ehab M., Albogami, Sarah, Fayad, Eman, Althobaiti, Fayez, Gouda, Ahmed M., Sileem, Ashraf E., Elfaky, Mahmoud A., Darwish, Khaled M., Alaa Eldeen, Muhammad

“…The NRAS gene is a well-known oncogene that acts as a major player in carcinogenesis. Mutations in the NRAS gene have been linked to multiple types of human…”
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Design, Synthesis, and Biological Evaluation of Some Novel Pyrrolizine Derivatives as COX Inhibitors with Anti-Inflammatory/Analgesic Activities and Low Ulcerogenic Liability by Gouda, Ahmed M, Ali, Hamed I, Almalki, Waleed H, Azim, Mohamed A, Abourehab, Mohammed A S, Abdelazeem, Ahmed H

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed anti-inflammatory and pain relief medications. However, their use is associated…”
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Exploring Ventilator-Associated Pneumonia: Microbial Clues and Biomarker Insights from a Retrospective Study by Gouda, Ahmed M, Sileem, Ashraf E, Elnahas, Hanan M, Tawfik, Ahmed E, Eid, Refaat A, Shati, Ayed A, Al-Qahtani, Saleh M, Dawood, Samy A, Alshehri, Mohammed A, Eissa, Mohamed, Soltan, Mohamed A, Noreldin, Ahmed E, Elwishahy, Amir Helmy, Negm, Essamedin M

“…: Ventilator-associated pneumonia (VAP) is a common complication in critically ill patients receiving mechanical ventilation. The incidence rates of VAP vary,…”
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In Silico Designing of a Multitope Vaccine against Rhizopus microsporus with Potential Activity against Other Mucormycosis Causing Fungi by Soltan, Mohamed A, Eldeen, Muhammad Alaa, Elbassiouny, Nada, Kamel, Hasnaa L, Abdelraheem, Kareem M, El-Gayyed, Hanaa Abd, Gouda, Ahmed M, Sheha, Mohammed F, Fayad, Eman, Ali, Ola A Abu, Ghany, Khalid Abd El, El-Damasy, Dalia A, Darwish, Khaled M, Elhady, Sameh S, Sileem, Ashraf E

“…During the current era of the COVID-19 pandemic, the dissemination of Mucorales has been reported globally, with elevated rates of infection in India, and…”
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Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases by Mohassab, Aliaa M., Hassan, Heba A., Abdelhamid, Dalia, Gouda, Ahmed M., Youssif, Bahaa G.M., Tateishi, Hiroshi, Fujita, Mikako, Otsuka, Masami, Abdel-Aziz, Mohamed

“…[Display omitted] •A series of quinoline/chalcone/1,2,4-triazole hybrids was synthesized and tested by NCI for their anticancer activity.•7b, 7d, 9b, and 9d…”
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Integration of immunoinformatics and cheminformatics to design and evaluate a multitope vaccine against Klebsiella pneumoniae and Pseudomonas aeruginosa coinfection by Gouda, Ahmed M, Soltan, Mohamed A, Abd-Elghany, Khalid, Sileem, Ashraf E, Elnahas, Hanan M, Ateya, Marwa Abdel-Monem, Elbatreek, Mahmoud H, Darwish, Khaled M, Bogari, Hanin A, Lashkar, Manar O, Aldurdunji, Mohammed M, Elhady, Sameh S, Ahmad, Tarek A, Said, Ahmed Mohamed

“…( ) and ( ) are the most common Gram-negative bacteria associated with pneumonia and coinfecting the same patient. Despite their high virulence, there is no…”
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Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency by Shawky, Ahmed M., Abourehab, Mohammed A.S., Abdalla, Ashraf N., Gouda, Ahmed M.

“…Two new series of pyrrolizine-5-carboxamides were synthesized and evaluated for their anticancer and anti-inflammatory activities. The new compounds exhibited…”
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Discovery of new pyrimidopyrrolizine/indolizine-based derivatives as P-glycoprotein inhibitors: Design, synthesis, cytotoxicity, and MDR reversal activities by Shawky, Ahmed M., Abdalla, Ashraf N., Ibrahim, Nashwa A., Abourehab, Mohammed A.S., Gouda, Ahmed M.

“…Targeting P-glycoprotein (P-gp, ABCB1 transporter), which plays an essential role in multi-drug resistance (MDR) in cancers, with new cytotoxic agents is a…”
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An integrated overview on pyrrolizines as potential anti-inflammatory, analgesic and antipyretic agents by Gouda, Ahmed M., Abdelazeem, Ahmed H.

“…Despite the existence of huge number of NSAIDs, the quest for safer drugs is still in the focus of several drug discovery programs. Pyrrolizine heterocyclic…”
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