Search Results - "Gouchoe, Doug A."

The Next Frontier in Lung Transplantation: Protecting the Endothelium and Repairing Organs for Transplant Utilizing MG53 by Gouchoe, Doug A., Whitson, Bryan A., Zhu, Hua

“…Additionally, DAMPs can initiate release of tumor necrosis factor-alpha (TNF-α), which when bound to its receptors recruits cytosolic adaptor proteins to form…”
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Improving lung allograft function in the early post-operative period through the inhibition of pyroptosis by Gouchoe, Doug A., Zhang, Zhentao, Kim, Jung-Lye, Lee, Yong Gyu, Whitson, Bryan A., Zhu, Hua

“…Lung transplantation is the only definitive therapy for end-stage pulmonary disease. Less than 20 % of offered lungs are successfully transplanted due to a…”
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Is Time Scheduling Important? An Analysis of Donor Heart Cross-clamp Times During Heart Transplantation by Gouchoe, Doug A, Ganapathi, Asvin M, Cui, Ervin Y, Henn, Matthew C, Yim, Wai Yen, Geng, Bingchuan, Whitson, Bryan A, Zhu, Hua

“…Outcomes in heart transplantation are affected by a variety of variables and patient factors. However, the impact of circadian rhythms, gene expression, and…”
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Long Survival Following Lung Transplantation: What Matters? by Zhao, Jane Y., Gouchoe, Doug A., Schwartzman, William E., Rosenheck, Justin P., Heh, Victor, Henn, Matthew C., Mokadam, Nahush A., Nunley, David R., Whitson, Bryan A., Ganapathi, Asvin M.

“…A retrospective review of the UNOS/OPTN Database was performed from 1 October 1987–31 December 2019. Recipients were classified as LSu (15+ years survival…”
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MG53 mitigates warm ischemic lung injury in a murine model of transplantation by Gouchoe, Doug A., Yi, Tai, Kim, Jung-Lye, Lee, Yong Gyu, Black, Sylvester M., Breuer, Christopher, Ma, Jianjie, Whitson, Bryan A.

“…Lung transplant warm ischemia–reperfusion injury (IRI) results in cellular injury, inflammation, and poor graft function. Mitsugumin 53 (MG53) is an endogenous…”
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Mitsugumin 53 mitigation of ischemia–reperfusion injury in a mouse model by Gouchoe, Doug A., Lee, Yong Gyu, Kim, Jung Lye, Zhang, Zhentao, Marshall, Joanna M., Ganapathi, Asvin, Zhu, Hua, Black, Sylvester M., Ma, Jianjie, Whitson, Bryan A.

“…Primary graft dysfunction is often attributed to ischemia–reperfusion injury, and prevention would be a therapeutic approach to mitigate injury. Mitsugumin 53,…”
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XPS™ Jensen lung as a low‐cost, high‐fidelity training adjunct to ex‐vivo lung perfusion by Gouchoe, Doug A., Shukrallah, Basam, Eggeman, Chad, Igoe, David, Ralston, James, Mast, David, Ganapathi, Asvin M., Whitson, Bryan A.

“…Abstract Background Ex vivo lung perfusion (EVLP) enables lung resuscitation before transplantation, and training is key, particularly in low‐volume settings…”
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Long-Term Survival Following Primary Graft Dysfunction Development in Lung Transplantation by Gouchoe, Doug A., Whitson, Bryan A., Rosenheck, Justin, Henn, Matthew C., Mokadam, Nahush A., Ramsammy, Verai, Kirkby, Stephen, Nunley, David, Ganapathi, Asvin M.

“…Primary graft dysfunction (PGD) is a known risk factor for early mortality following lung transplant (LT). However, the outcomes of patients who achieve…”
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Prime editing‐mediated correction of the leptin receptor in muscle cells of db/db mice by Lee, Kyung Eun, Xu, Yanping, Geng, Bingchuan, Kim, Jongsoo, Kellon, Natalie, He, Zhixian, Zhang, Zhentao, Li, Deqiang, Gouchoe, Doug A., Zhu, Hua

“…Genetic diseases can be caused by monogenic diseases, which result from a single gene mutation in the DNA sequence. Many innovative approaches have been…”
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Ex Vivo Lung Perfusion in Donation after Cardiac and Brain Death Donation by Gouchoe, Doug A., Cui, Ervin Y., Satija, Divyaam, Heh, Victor, Darcy, Christine E., Henn, Matthew C., Choi, Kukbin, Nunley, David R., Mokadam, Nahush A., Ganapathi, Asvin M., Whitson, Bryan A.

“…Allografts from donation after circulatory death (DCD) or brain death donors may be evaluated by ex vivo lung perfusion (EVLP) to assess quality for…”
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Does Size Matter? The Effect of Size of Distal Perfusion Catheter on Acute Limb Ischemia: A Meta-Analysis by Gouchoe, Doug A, Chaurasia, Sameer, Henn, Matthew C, Whitson, Bryan A, Mokadam, Nahush A, Mast, David, Satyapriya, Sree, Vallakati, Ajay, Ganapathi, Asvin M

“…Prevention of limb ischemia in patients with venoarterial extracorporeal membrane oxygenation (VA-ECMO) is primarily achieved through the use of distal…”
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An Unexpected Partnership: Alexis Carrel, Charles Lindbergh, and Normothermic Machine Perfusion by Cui, Ervin Y, Gouchoe, Doug A, Salmon-Rekhi, Suhavi T, Whitson, Bryan A, Black, Sylvester M

“…Organ transplantation is a triumph of modern medicine which represents a culmination of science and imagination, saving thousands of lives a year. However,…”
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Early Extubation: Who Qualifies Postoperatively in Lung Transplantation? by Habib, Alim, Gouchoe, Doug A., Rosenheck, Justin P., Mokadam, Nahush A., Henn, Matthew C., Nunley, David R., Ramsammy, Verai, Whitson, Bryan A., Ganapathi, Asvin M.

“…Early extubation has been adopted in many settings within cardiothoracic surgery, with several advantages for patients. We sought to determine the association…”
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Biometric Profiling to Quantify Lung Injury Through Ex Vivo Lung Perfusion Following Warm Ischemia by Kim, Jung-Lye, Gouchoe, Doug A., Reader, Brenda F., Dumond, Curtis, Lee, Yong Gyu, Black, Sylvester M., Whitson, Bryan A.

“…Standard physiologic assessment parameters of donor lung grafts may not accurately reflect lung injury or quality. A biometric profile of ischemic injury could…”
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Ex vivo lung perfusion in donation after circulatory death: A post hoc analysis of the Normothermic Ex Vivo Lung Perfusion as an Assessment of Extended/Marginal Donors Lungs trial by Gouchoe, Doug A., Sanchez, Pablo G., D’Cunha, Jonathan, Bermudez, Christian A., Daneshmand, Mani A., Davis, Robert D., Hartwig, Matthew G., Wozniak, Thomas C., Kon, Zachary N., Griffith, Bartley P., Lynch, William R., Machuca, Tiago N., Weyant, Michael J., Jessen, Michael E., Mulligan, Michael S., D’Ovidio, Frank, Camp, Phillip C., Cantu, Edward, Whitson, Bryan A., Sanchez, Pablo G., Ryan, John P., Davis, Robert D., Hartwig, Matthew G., Machuca, Tiago N., Daneshmand, Mani A., D’Ovidio, Frank, D’Cunha, Jonathan, Bermudez, Christian A., Weyant, Michael J., Jessen, Michael E., Mulligan, Michael S., Wozniak, Thomas, Lynch, William, Nemeh, Hassan, Caldeira, Christiano, Song, Tae, Kreisel, Daniel, Camp, Phillip C., Ramzy, Danny, Griffith, Bartley P., Cantu, Edward, Whitson, Bryan A.

“…Donation after circulatory death (DCD) donors offer the ability to expand the lung donor pool and ex vivo lung perfusion (EVLP) further contributes to this…”
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The impact of ex vivo lung perfusion location on lung transplant outcomes by Gouchoe, Doug A., Satija, Divyaam, Cui, Ervin Y., Ferrari‐Light, Dana, Henn, Matthew C., Choi, Kukbin, Mokadam, Nahush A., Ganapathi, Asvin M., Whitson, Bryan A.

“…Background Ex vivo lung perfusion (EVLP) conducted outside of the transplant center has increased in recent years to mitigate its limitation by resources and…”
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Extended ischemic times during ex vivo lung perfusion is not associated with increased mortality by Gouchoe, Doug A., Satija, Divyaam, Cui, Ervin Y., Aly, Ahmed, Henn, Matthew C., Choi, Kukbin, Nunley, David, Mokadam, Nahush A., Ganapathi, Asvin M., Whitson, Bryan A.

“…Background The purpose of this study was to identify the association of increasing ischemic times in recipients who receive lungs evaluated by ex vivo lung…”
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The role of CD38 in ischemia reperfusion injury in cardiopulmonary bypass and thoracic transplantation: a narrative review by Gouchoe, Doug A, Vijayakumar, Ammu, Aly, Ahmed H, Cui, Ervin Y, Essandoh, Michael, Gumina, Richard J, Black, Sylvester M, Whitson, Bryan A

“…Ischemia reperfusion injury (IRI) is often the underlying cause of endothelium breakdown and damage in cardiac or transplantation operations, which can lead to…”
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Is timing everything? Examining operative time in lung transplants from 2006 to 2023 by Doug A. Gouchoe, Ervin Y. Cui, Christine E. Darcy, Bryan A. Whitson, Asvin M. Ganapathi, Hua Zhu

“…Background: Several studies have tried to find a link between timing of lung transplant surgery and patient outcomes. However, there has been conflicting…”
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Racial and Ethnic Disparities in Peri-and Post-operative Cardiac Surgery by Scott, Shane S., Gouchoe, Doug A., Azap, Lovette, Henn, Matthew C., Choi, Kukbin, Mokadam, Nahush A., Whitson, Bryan A., Pawlik, Timothy M., Ganapathi, Asvin M.

“…Purpose of Review Despite efforts to curtail its impact on medical care, race remains a powerful risk factor for morbidity and mortality following cardiac…”
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