Search Results - "Gou, Yuanwei"
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Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae
Published in Communications biology (16-09-2021)“…Vindoline is a plant derived monoterpene indole alkaloid (MIA) with potential therapeutic applications and more importantly serves as the precursor to…”
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Intein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast
Published in Nature communications (19-06-2024)“…While sanguinarine has gained recognition for antimicrobial and antineoplastic activities, its complex conjugated structure and low abundance in plants impede…”
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Intricate Metabolic Network for Paclitaxel Biosynthesis
Published in Biodesign research (01-01-2024)“…Paclitaxel is a renowned broad-spectrum anticancer drug. With the establishment of a chromosome-level high-quality reference genome map of , recent research on…”
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Transportation engineering for enhanced production of plant natural products in microbial cell factories
Published in Synthetic and systems biotechnology (01-12-2024)“…Plant natural products (PNPs) exhibit a wide range of biological activities and have essential applications in various fields such as medicine, agriculture,…”
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De Novo Biosynthesis of Vindoline and Catharanthine in Saccharomyces cerevisiae
Published in Biodesign research (2022)“…Vinblastine has been used clinically as one of the most potent therapeutics for the treatment of several types of cancer. However, the traditional plant…”
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SgRNA engineering for improved genome editing and expanded functional assays
Published in Current opinion in biotechnology (01-06-2022)“…[Display omitted] •SgRNA engineering enables more powerful and versatile CRISPR/Cas9 systems.•The sgRNA engineering strategies are summarized in a structural…”
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Reconstitution and optimization of complex plant natural product biosynthetic pathways in microbial expression systems
Published in Current opinion in biotechnology (01-06-2024)“…Plant natural products (PNPs) are a diverse group of chemical compounds synthesized by plants for various biological purposes and play a significant role in…”
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Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast
Published in Biotechnology and bioengineering (01-05-2022)“…Yeast cell factories have been increasingly employed for producing plant‐derived natural products. Unfortunately, the stability of plant natural product…”
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Characterization and engineering of peroxisome targeting sequences for compartmentalization engineering in Pichia pastoris
Published in Biotechnology and bioengineering (01-07-2024)“…Peroxisomal compartmentalization has emerged as a highly promising strategy for reconstituting intricate metabolic pathways. In recent years, significant…”
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