Search Results - "Gottschling, Daniel E"

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast by Hughes, Adam L., Gottschling, Daniel E.

“…Vacuolar acidity in yeast is shown to decline with age, and preventing this decrease suppresses mitochondrial dysfunction and extends the lifespan of yeast…”
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The Upsides and Downsides of Organelle Interconnectivity by Gottschling, Daniel E., Nyström, Thomas

“…Interconnectivity and feedback control are hallmarks of biological systems. This includes communication between organelles, which allows them to function and…”
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Mother Enrichment Program: A Genetic System for Facile Replicative Life Span Analysis in Saccharomyces cerevisiae by Lindstrom, Derek L, Gottschling, Daniel E

“…The replicative life span (RLS) of Saccharomyces cerevisiae has been established as a model for the genetic regulation of longevity despite the inherent…”
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Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast by Henderson, Kiersten A, Hughes, Adam L, Gottschling, Daniel E

“…Replicative aging in yeast is asymmetric-mother cells age but their daughter cells are rejuvenated. Here we identify an asymmetry in pH between mother and…”
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Synthetic chromosome arms function in yeast and generate phenotypic diversity by design by Dymond, Jessica S., Richardson, Sarah M., Coombes, Candice E., Babatz, Timothy, Muller, Héloïse, Annaluru, Narayana, Blake, William J., Schwerzmann, Joy W., Dai, Junbiao, Lindstrom, Derek L., Boeke, Annabel C., Gottschling, Daniel E., Chandrasegaran, Srinivasan, Bader, Joel S., Boeke, Jef D.

“…A part-synthetic yeast genome A milestone in biology was reached in 2010, with the production of a viable bacterium with a genome that had been reassembled…”
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Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect by Veatch, Joshua R., McMurray, Michael A., Nelson, Zara W., Gottschling, Daniel E.

“…Mutations and deletions in the mitochondrial genome (mtDNA), as well as instability of the nuclear genome, are involved in multiple human diseases. Here, we…”
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Selective sorting and destruction of mitochondrial membrane proteins in aged yeast by Hughes, Adam L, Hughes, Casey E, Henderson, Kiersten A, Yazvenko, Nina, Gottschling, Daniel E

“…Mitochondrial dysfunction is a hallmark of aging, and underlies the development of many diseases. Cells maintain mitochondrial homeostasis through a number of…”
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rDNA array length is a major determinant of replicative lifespan in budding yeast by Hotz, Manuel, Thayer, Nathaniel H, Hendrickson, David G, Schinski, Elizabeth L, Xu, Jun, Gottschling, Daniel E

“…The complex processes and interactions that regulate aging and determine lifespan are not fully defined for any organism. Here, taking advantage of recent…”
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Independent regulation of age associated fat accumulation and longevity by Beas, Anthony O., Gordon, Patricia B., Prentiss, Clara L., Olsen, Carissa Perez, Kukurugya, Matthew A., Bennett, Bryson D., Parkhurst, Susan M., Gottschling, Daniel E.

“…Age-dependent changes in metabolism can manifest as cellular lipid accumulation, but how this accumulation is regulated or impacts longevity is poorly…”
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Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae by Lindstrom, Derek L, Leverich, Christina K, Henderson, Kiersten A, Gottschling, Daniel E

“…Somatic mutations contribute to the development of age-associated disease. In earlier work, we found that, at high frequency, aging Saccharomyces cerevisiae…”
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Identification of long-lived proteins retained in cells undergoing repeated asymmetric divisions by Thayer, Nathaniel H., Leverich, Christina K., Fitzgibbon, Matthew P., Nelson, Zara W., Henderson, Kiersten A., Gafken, Philip R., Hsu, Jessica J., Gottschling, Daniel E.

“…Long-lived proteins have been implicated in age-associated decline in metazoa, but they have only been identified in extracellular matrices or postmitotic…”
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Disorder Targets Misorder in Nuclear Quality Control Degradation: A Disordered Ubiquitin Ligase Directly Recognizes Its Misfolded Substrates by Rosenbaum, Joel C., Fredrickson, Eric K., Oeser, Michelle L., Garrett-Engele, Carrie M., Locke, Melissa N., Richardson, Lauren A., Nelson, Zara W., Hetrick, Elizabeth D., Milac, Thomas I., Gottschling, Daniel E., Gardner, Richard G.

“…Protein quality control (PQC) degradation systems protect the cell from the toxic accumulation of misfolded proteins. Because any protein can become misfolded,…”
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Dot1p Modulates Silencing in Yeast by Methylation of the Nucleosome Core by van Leeuwen, Fred, Gafken, Philip R., Gottschling, Daniel E.

“…DOT1 was originally identified as a gene affecting telomeric silencing in S. cerevisiae. We now find that Dot1p methylates histone H3 on lysine 79, which maps…”
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A mother’s sacrifice: what is she keeping for herself? by Henderson, Kiersten A, Gottschling, Daniel E

“…Individual cells of the budding yeast, Saccharomyces cerevisiae , have a limited life span and undergo a form of senescence termed replicative aging…”
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Degradation-Mediated Protein Quality Control in the Nucleus by Gardner, Richard G., Nelson, Zara W., Gottschling, Daniel E.

“…Protein quality control degradation systems rid the cell of aberrant proteins, preventing detrimental effects on normal cellular function. Although such…”
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The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote by Schübeler, Dirk, MacAlpine, David M, Scalzo, David, Wirbelauer, Christiane, Kooperberg, Charles, van Leeuwen, Fred, Gottschling, Daniel E, O'Neill, Laura P, Turner, Bryan M, Delrow, Jeffrey, Bell, Stephen P, Groudine, Mark

“…The covalent modification of nucleosomal histones has emerged as a major determinant of chromatin structure and gene activity. To understand the interplay…”
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An Age-Induced Switch to a Hyper-Recombinational State by McMurray, Michael A., Gottschling, Daniel E.

“…There is a strong correlation between age and cancer, but the mechanism by which this phenomenon occurs is unclear. We chose Saccharomyces cerevisiae to…”
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Recombination-induced tag exchange to track old and new proteins by Verzijlbergen, Kitty F, Menendez-Benito, Victoria, van Welsem, Tibor, van Deventer, Sjoerd J, Lindstrom, Derek L, Ovaa, Huib, Neefjes, Jacques, Gottschling, Daniel E, van Leeuwen, Fred

“…The dynamic behavior of proteins is critical for cellular homeostasis. However, analyzing dynamics of proteins and protein complexes in vivo has been…”
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Ubp10/Dot4p Regulates the Persistence of Ubiquitinated Histone H2B: Distinct Roles in Telomeric Silencing and General Chromatin by Gardner, Richard G., Nelson, Zara W., Gottschling, Daniel E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of a Small Molecule Inhibitor of Sir2p by Bedalov, Antonio, Gatbonton, Tonibelle, Irvine, William P., Gottschling, Daniel E., Simon, Julian A.

“…Sir2p is an NAD+-dependent histone deacetylase required for chromatin-dependent silencing in yeast. In a cell-based screen for inhibitors of Sir2p, we…”
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