Search Results - "Gottschall, Paul E."

ADAMTS expression and function in central nervous system injury and disorders by Gottschall, Paul E., Howell, Matthew D.

“…The components of the adult extracellular matrix in the central nervous system form a lattice-like structure that is deposited as perineuronal nets, around…”
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Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms by Phelan, Kevin D, Shwe, U Thaung, Abramowitz, Joel, Wu, Hong, Rhee, Sung W, Howell, Matthew D, Gottschall, Paul E, Freichel, Marc, Flockerzi, Veit, Birnbaumer, Lutz, Zheng, Fang

“…Seizures are the manifestation of highly synchronized burst firing of a large population of cortical neurons. Epileptiform bursts with an underlying plateau…”
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Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1 by Howell, Matthew D, Torres-Collado, Antoni X, Iruela-Arispe, M Luisa, Gottschall, Paul E

“…The chondroitin sulfate-bearing proteoglycans, also known as lecticans, are a major component of the extracellular matrix (ECM) in the central nervous system…”
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Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice by Howell, Matthew D, Bailey, Lauren A, Cozart, Michael A, Gannon, Brenda M, Gottschall, Paul E

“…Substantial data has shown that the lectican group of chondroitin sulfate proteoglycans are involved in inhibition of axonal plasticity in response to injury…”
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Pre-assembled clusters distort crystal nucleation kinetics in supersaturated lysozyme solutions by Parmar, Avanish S., Gottschall, Paul E., Muschol, Martin

“…Efficient determination of three-dimensional protein structures is critical for unraveling structure–function relationships and for supporting targeted drug…”
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Multimodal signaling by the ADAMTSs ( a disintegrin and metalloproteinase with thrombo spondin motifs) promotes neurite extension by Hamel, Michelle G., Ajmo, Joanne M., Leonardo, Christopher C., Zuo, Fengrong, Sandy, John D., Gottschall, Paul E.

“…Aggregating proteoglycans (PG) bearing chondroitin sulfate (CS) side chains associate with hyaluronan and various secreted proteins to form a complex of…”
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Discordant localization of WFA reactivity and brevican/ADAMTS-derived fragment in rodent brain by Ajmo, Joanne M, Eakin, Autumn K, Hamel, Michelle G, Gottschall, Paul E

“…Proteoglycan (PG) in the extracellular matrix (ECM) of the central nervous system (CNS) may act as a barrier for neurite elongation in a growth tract, and…”
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Activation of the Proteolytic Activity of ADAMTS4 (Aggrecanase-1) by C-terminal Truncation by Gao, Gui, Westling, Jennifer, Thompson, Vivian P., Howell, Troy D., Gottschall, Paul E., Sandy, John D.

“…Proteolysis of the hyalectans (aggrecan, versican, brevican) in vivo appears to result from the activity of ADAMTS4 (aggrecanase-1, herein referred to as an…”
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Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw by Ajmo, Joanne M, Bailey, Lauren A, Howell, Matthew D, Cortez, Lisa K, Pennypacker, Keith R, Mehta, Hina N, Morgan, Dave, Gordon, Marcia N, Gottschall, Paul E

“…J. Neurochem. (2010) 113, 784-795. Aggregation of amyloid-β (Aβ) in the forebrain of Alzheimer's disease (AD) subjects may disturb the molecular organization…”
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Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat by Leonardo, Christopher C, Eakin, Autumn K, Ajmo, Joanne M, Collier, Lisa A, Pennypacker, Keith R, Strongin, Alex Y, Gottschall, Paul E

“…Hypoxia-ischemia (H-I) can produce widespread neurodegeneration and deep cerebral white matter injury in the neonate. Resident microglia and invading…”
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Altered synaptic marker abundance in the hippocampal stratum oriens of Ts65Dn mice is associated with exuberant expression of versican by Howell, Matthew D, Gottschall, Paul E

“…DS (Down syndrome), resulting from trisomy of chromosome 21, is the most common cause of genetic mental retardation; however, the molecular mechanisms…”
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Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice by Carty, Niki C, Wilcock, Donna M, Rosenthal, Arnon, Grimm, Jan, Pons, Jaume, Ronan, Victoria, Gottschall, Paul E, Gordon, Marcia N, Morgan, Dave

“…Abstract Background Antibodies against the Aß peptide clear Aß deposits when injected intracranially. Deglycosylated antibodies have reduced effector functions…”
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Evidence for proteolytic cleavage of brevican by the ADAMTSs in the dentate gyrus after excitotoxic lesion of the mouse entorhinal cortex by Mayer, Joanne, Hamel, Michelle G, Gottschall, Paul E

“…Brevican is a member of the lectican family of aggregating extracellular matrix (ECM) proteoglycans that bear chondroitin sulfate (CS) chains. It is highly…”
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Regional and differential expression of gelatinases in rat brain after systemic kainic acid or bicuculline administration by Zhang, J. Wenjun, Deb, Suman, Gottschall, Paul E.

“…Indirect evidence from in vitro studies implicates a functional role for matrix metalloproteinases (MMPs) in the central nervous system (CNS), including…”
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Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice by Lebson, Lori, Nash, Kevin, Kamath, Siddharth, Herber, Donna, Carty, Nikisha, Lee, Daniel C, Li, Qingyou, Szekeres, Karoly, Jinwal, Umesh, Koren, John, Dickey, Chad A, Gottschall, Paul E, Morgan, Dave, Gordon, Marcia N

“…A major question for gene therapy in brain concerns methods to administer therapeutic genes in a uniform manner over major portions of the brain. A second…”
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The effect of hypoxic–ischemic brain injury in perinatal rats on the abundance and proteolysis of brevican and NG2 by Aya-ay, James, Mayer, Joanne, Eakin, Autumn K., Muffly, Barbara G., Anello, Margaret, Sandy, John D., Gottschall, Paul E.

“…Oligodendrocyte (OL) progenitor cells are particularly susceptible to perinatal hypoxia/ischemia (H–I) resulting in decreased myelination and attenuated…”
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Deglycosylated Anti-Amyloid-beta Antibodies Eliminate Cognitive Deficits and Reduce Parenchymal Amyloid with Minimal Vascular Consequences in Aged Amyloid Precursor Protein Transgenic Mice by Wilcock, Donna M, Alamed, Jennifer, Gottschall, Paul E, Grimm, Jan, Rosenthal, Arnon, Pons, Jaume, Ronan, Victoria, Symmonds, Keisha, Gordon, Marcia N, Morgan, Dave

“…Systemic administration of anti-amyloid-beta (Abeta) antibodies results in reduced parenchymal amyloid but increased vascular amyloid and microhemorrhage in…”
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Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease by Morgan, Dave, Diamond, David M, Gottschall, Paul E, Ugen, Kenneth E, Dickey, Chad, Hardy, John, Duff, Karen, Jantzen, Paul, DiCarlo, Giovanni, Wilcock, Donna, Connor, Karen, Hatcher, Jaime, Hope, Caroline, Gordon, Marcia, Arendash, Gary W

“…Vaccinations with amyloid-β peptide (AB) can dramatically reduce amyloid deposition in a transgenic mouse model of Alzheimer's disease. To determine if the…”
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Role and mechanisms of interleukin-1 in the modulation of neurotoxicity by Ma, Xiaoling C, Gottschall, Paul E, Chen, Li T, Wiranowska, Marzenna, Phelps, Christopher P

“…Recent studies on cerebral ischemia in the rat have demonstrated that administration of interleukin-1 receptor antagonist (IL-1ra) markedly reduces the volumes…”
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Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice by Carty, Niki C, Nash, Kevin, Lee, Daniel, Mercer, Mary, Gottschall, Paul E, Meyers, Craig, Muzyczka, Nicholas, Gordon, Marcia N, Morgan, Dave

“…Reduction of Aβ deposition is a major therapeutic strategy in Alzheimer's disease (AD). The concentration of Aβ in the brain is modulated not only by Aβ…”
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