Search Results - "Gottschalk, Laura"

Capitalizing on the heterogeneous effects of CFTR nonsense and frameshift variants to inform therapeutic strategy for cystic fibrosis by Sharma, Neeraj, Evans, Taylor A, Pellicore, Matthew J, Davis, Emily, Aksit, Melis A, McCague, Allison F, Joynt, Anya T, Lu, Zhongzhu, Han, Sangwoo T, Anzmann, Arianna F, Lam, Anh-Thu N, Thaxton, Abigail, West, Natalie, Merlo, Christian, Gottschalk, Laura B, Raraigh, Karen S, Sosnay, Patrick R, Cotton, Calvin U, Cutting, Garry R

“…CFTR modulators have revolutionized the treatment of individuals with cystic fibrosis (CF) by improving the function of existing protein. Unfortunately, almost…”
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The perilipin homologue, lipid storage droplet 2, regulates sleep homeostasis and prevents learning impairments following sleep loss by Thimgan, Matthew S, Suzuki, Yasuko, Seugnet, Laurent, Gottschalk, Laura, Shaw, Paul J

“…Extended periods of waking result in physiological impairments in humans, rats, and flies. Sleep homeostasis, the increase in sleep observed following sleep…”
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D1 Receptor Activation in the Mushroom Bodies Rescues Sleep-Loss-Induced Learning Impairments in Drosophila by Seugnet, Laurent, Suzuki, Yasuko, Vine, Lucy, Gottschalk, Laura, Shaw, Paul J.

“…Extended wakefulness disrupts acquisition of short-term memories in mammals. However, the underlying molecular mechanisms triggered by extended waking and…”
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Improving the Performance of Lithium‐Ion Batteries Using a Two‐Layer, Hard Carbon‐Containing Silicon Anode for Use in High‐Energy Electrodes by Gottschalk, Laura, Oertel, Christine, Strzelczyk, Nanny, Müller, Jannes, Krüger, Jannik, Haselrieder, Wolfgang, Kwade, Arno

“…Lithium‐ion battery cells with high‐energy density and good fast charging properties are subject of current research. One approach to achieve high‐energy…”
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Diversity in Medical Device Clinical Trials: Do We Know What Works for Which Patients? by FOX-RAWLINGS, STEPHANIE R., GOTTSCHALK, LAURA B., DOAMEKPOR, LAURÉN A., ZUCKERMAN, DIANA M.

“…Context: Demographic differences can influence the safety and effectiveness of medical devices; however, clinical trials of devices for adults have…”
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Spherical Graphite Anodes: Influence of Particle Size Distribution and Multilayer Structuring in Lithium-Ion Battery Cells by Gottschalk, Laura, Müller, Jannes, Schoo, Alexander, Baasch, Ernesto, Kwade, Arno

“…Current research focuses on lithium-ion battery cells with a high energy density and efficient fast-charging capabilities. However, transport limitations, and,…”
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Experimental Assessment of Splicing Variants Using Expression Minigenes and Comparison with In Silico Predictions by Sharma, Neeraj, Sosnay, Patrick R., Ramalho, Anabela S., Douville, Christopher, Franca, Arianna, Gottschalk, Laura B., Park, Jeenah, Lee, Melissa, Vecchio-Pagan, Briana, Raraigh, Karen S., Amaral, Margarida D., Karchin, Rachel, Cutting, Garry R.

“…ABSTRACT Assessment of the functional consequences of variants near splice sites is a major challenge in the diagnostic laboratory. To address this issue, we…”
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Notch Signaling Modulates Sleep Homeostasis and Learning after Sleep Deprivation in Drosophila by Seugnet, Laurent, Suzuki, Yasuko, Merlin, Gabriel, Gottschalk, Laura, Duntley, Stephen P., Shaw, Paul J.

“…The role of the transmembrane receptor Notch in the adult brain is poorly understood. Here, we provide evidence that bunched, a negative regulator of Notch, is…”
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Creation and characterization of an airway epithelial cell line for stable expression of CFTR variants by Gottschalk, Laura B, Vecchio-Pagan, Briana, Sharma, Neeraj, Han, Sangwoo T, Franca, Arianna, Wohler, Elizabeth S, Batista, Denise A.S, Goff, Loyal A, Cutting, Garry R

“…Abstract Background Analysis of the functional consequences and treatment response of rare CFTR variants is challenging due to the limited availability of…”
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A sequence upstream of canonical PDZ-binding motif within CFTR COOH-terminus enhances NHERF1 interaction by Sharma, Neeraj, LaRusch, Jessica, Sosnay, Patrick R, Gottschalk, Laura B, Lopez, Andrea P, Pellicore, Matthew J, Evans, Taylor, Davis, Emily, Atalar, Melis, Na, Chan-Hyun, Rosson, Gedge D, Belchis, Deborah, Milewski, Michal, Pandey, Akhilesh, Cutting, Garry R

“…The development of cystic fibrosis transmembrane conductance regulator (CFTR) targeted therapy for cystic fibrosis has generated interest in maximizing…”
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Identification of a biomarker for sleep drive in flies and humans by Seugnet, L, Boero, J, Gottschalk, L, Duntley, S.P, Shaw, P.J

“…It is a common experience to sacrifice sleep to meet the demands of our 24-h society. Current estimates reveal that as a society, we sleep on average 2 h less…”
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Cross-translational studies in human and Drosophila identify markers of sleep loss by Thimgan, Matthew S, Gottschalk, Laura, Toedebusch, Cristina, McLeland, Jennifer, Rechtschaffen, Allan, Gilliland-Roberts, Marcia, Duntley, Stephen P, Shaw, Paul J

“…Inadequate sleep has become endemic, which imposes a substantial burden for public health and safety. At present, there are no objective tests to determine if…”
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Inducing Sleep by Remote Control Facilitates Memory Consolidation in Drosophila by Donlea, Jeffrey M., Thimgan, Matthew S., Suzuki, Yasuko, Gottschalk, Laura, Shaw, Paul J.

“…Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel…”
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Influence of different anode active materials and blends on the performance and fast-charging capability of lithium-ion battery cells by Gottschalk, Laura, Strzelczyk, Nanny, Adam, Alexander, Kwade, Arno

“…To further extent the driving range of battery electric vehicles, an increase of the energy density of lithium-ion battery cells is necessary. One way to…”
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Structuring Electrodes for Lithium‐Ion Batteries: A Novel Material Loss‐Free Process Using Liquid Injection by Bredekamp, Michael, Gottschalk, Laura, Peter, Michalowski, Kwade, Arno

“…One possible approach to improve the fast charging performance of lithium‐ion batteries (LIBs) is to create diffusion channels in the electrode coating. Laser…”
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The Influence of Calendering on the Fast Charging Performance and Lithium Plating of Hard Carbon Blend Anodes by Strzelczyk, Nanny, Gottschalk, Laura, Müller, Jannes, Kwade, Arno

“…Lithium‐ion batteries ensuring high energy densities are the focus of ongoing research. The main challenge is the fast charging capability, which is restricted…”
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US Food and Drug Administration and Off-Label Use of Metal Expandable Biliary Stents within the Peripheral Vasculature—Update by Marrone, April K., Gottschalk, Laura, Chen, Allen L.

“…In the past, some medical device manufacturers were obtaining marketing clearance for metallic stents indicated for biliary use; however, these devices were…”
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Research-practice partnership: supporting rural cancer survivors in Montana by Gordon, Janna R., Yack, Melissa, Kikuchi, Kara, Stevens, Leticia, Merchant, Leah, Buys, Courtney, Gottschalk, Laura, Frame, Melanie, Mussetter, Jessica, Younkin, Stephanie, Zimmerman, Heather, Kirchhoff, Anne C., Wetter, David W.

“…The objective of this Research-Practice Partnership was to disseminate and implement strategies to assist Community Health Centers in improving the care of…”
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Food and Drug Administration insights on clinical study of weight‐loss devices intended for adolescent patients by Marrone, April K., Venkataraman‐Rao, Priya, Gottschalk, Laura

“…Summary Background Medical devices intended for weight loss may provide clinically meaningful benefit to children who are overweight and have obesity; however,…”
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Sleep deprivation during early-adult development results in long-lasting learning deficits in adult Drosophila by Seugnet, Laurent, Suzuki, Yasuko, Donlea, Jeff M, Gottschalk, Laura, Shaw, Paul J

“…Multiple lines of evidence indicate that sleep is important for the developing brain, although little is known about which cellular and molecular pathways are…”
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