Search Results - "Gottlieb, Tanya"

Validation of a Novel Assay to Distinguish Bacterial and Viral Infections by Srugo, Isaac, Klein, Adi, Stein, Michal, Golan-Shany, Orit, Kerem, Nogah, Chistyakov, Irina, Genizi, Jacob, Glazer, Oded, Yaniv, Liat, German, Alina, Miron, Dan, Shachor-Meyouhas, Yael, Bamberger, Ellen, Oved, Kfir, Gottlieb, Tanya M, Navon, Roy, Paz, Meital, Etshtein, Liat, Boico, Olga, Kronenfeld, Gali, Eden, Eran, Cohen, Robert, Chappuy, Helène, Angoulvant, François, Lacroix, Laurence, Gervaix, Alain

“…Reliably distinguishing bacterial from viral infections is often challenging, leading to antibiotic misuse. A novel assay that integrates measurements of…”
Get full text

Host biomarkers and combinatorial scores for the detection of serious and invasive bacterial infection in pediatric patients with fever without source by Lacroix, Laurence, Papis, Sebastien, Mardegan, Chiara, Luterbacher, Fanny, L'Huillier, Arnaud, Sahyoun, Cyril, Keitel, Kristina, Mastboim, Niv, Etshtein, Liat, Shani, Liran, Simon, Einav, Barash, Eran, Navon, Roy, Gottlieb, Tanya M, Oved, Kfir, Eden, Eran, Combescure, Christophe, Galetto-Lacour, Annick, Gervaix, Alain

“…Background Improved tools are required to detect bacterial infection in children with fever without source (FWS), especially when younger than 3 years old. The…”
Get full text

Observational cohort study of IP-10's potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19 by Lev, Shaul, Gottesman, Tamar, Sahaf Levin, Gal, Lederfein, Doron, Berkov, Evgeny, Diker, Dror, Zaidman, Aliza, Nutman, Amir, Ilan Ber, Tahel, Angel, Alon, Kellerman, Lior, Barash, Eran, Navon, Roy, Boico, Olga, Israeli, Yael, Rosenberg, Michal, Gelman, Amir, Kalfon, Roy, Simon, Einav, Avni, Noa, Hainrichson, Mary, Zarchin, Oren, Gottlieb, Tanya M, Oved, Kfir, Eden, Eran, Tadmor, Boaz

“…Treatment of severely ill COVID-19 patients requires simultaneous management of oxygenation and inflammation without compromising viral clearance. While…”
Get full text

A host-protein signature is superior to other biomarkers for differentiating between bacterial and viral disease in patients with respiratory infection and fever without source: a prospective observational study by Ashkenazi-Hoffnung, Liat, Oved, Kfir, Navon, Roy, Friedman, Tom, Boico, Olga, Paz, Meital, Kronenfeld, Gali, Etshtein, Liat, Cohen, Asi, Gottlieb, Tanya M., Eden, Eran, Chistyakov, Irina, Srugo, Isaac, Klein, Adi, Ashkenazi, Shai, Scheuerman, Oded

“…Bacterial and viral infections often present with similar symptoms. Etiologic misdiagnosis can alter the trajectory of patient care, including antibiotic…”
Get full text

A host signature based on TRAIL, IP-10, and CRP for reducing antibiotic overuse in children by differentiating bacterial from viral infections: a prospective, multicentre cohort study by Papan, Cihan, Argentiero, Alberto, Porwoll, Marian, Hakim, Ummaya, Farinelli, Edoardo, Testa, Ilaria, Pasticci, Maria Bruna, Mezzetti, Daniele, Perruccio, Katia, Etshtein, Liat, Mastboim, Niv, Moscoviz, Einat, Ber, Tahel Ilan, Cohen, Asi, Simon, Einav, Boico, Olga, Shani, Liran, Gottlieb, Tanya M., Navon, Roy, Barash, Eran, Oved, Kfir, Eden, Eran, Simon, Arne, Liese, Johannes G., Knuf, Markus, Stein, Michal, Yacobov, Renata, Bamberger, Ellen, Schneider, Sven, Esposito, Susanna, Tenenbaum, Tobias

“…Identifying infection aetiology is essential for appropriate antibiotic use. Previous studies have shown that a host-protein signature consisting of…”
Get full text

Unlocking the power of the host response to improve the management of infectious diseases by Oved, Kfir, Eden, Eran, Gottlieb, Tanya M

“…[...]the test must overcome the challenge of ‘false’ findings due to colonization and carriage of ‘bystander’ microbes that are not related to the acute…”
Get full text

The diagnostic value of nasal microbiota and clinical parameters in a multi-parametric prediction model to differentiate bacterial versus viral infections in lower respiratory tract infections by Li, Yunlei, van Houten, Chantal B, Boers, Stefan A, Jansen, Ruud, Cohen, Asi, Engelhard, Dan, Kraaij, Robert, Hiltemann, Saskia D, Ju, Jie, Fernández, David, Mankoc, Cristian, González, Eva, de Waal, Wouter J, de Winter-de Groot, Karin M, Wolfs, Tom F W, Meijers, Pieter, Luijk, Bart, Oosterheert, Jan Jelrik, Sankatsing, Sanjay U C, Bossink, Aik W J, Stein, Michal, Klein, Adi, Ashkar, Jalal, Bamberger, Ellen, Srugo, Isaac, Odeh, Majed, Dotan, Yaniv, Boico, Olga, Etshtein, Liat, Paz, Meital, Navon, Roy, Friedman, Tom, Simon, Einav, Gottlieb, Tanya M, Pri-Or, Ester, Kronenfeld, Gali, Oved, Kfir, Eden, Eran, Stubbs, Andrew P, Bont, Louis J, Hays, John P

“…The ability to accurately distinguish bacterial from viral infection would help clinicians better target antimicrobial therapy during suspected lower…”
Get full text

A point-of-need platform for rapid measurement of a host-protein score that differentiates bacterial from viral infection: Analytical evaluation by Hainrichson, Mary, Avni, Noa, Eden, Eran, Feigin, Paul, Gelman, Amir, Halabi, Salim, Hartog-David, Efrat, Hulten, Kristina G., Jalal, Ashkar, Kalfon, Roy, Lamberth, Linda, Lewis, Shawna, Navon, Roy, Oved, Kfir, Raz-Pasteur, Ayelet, Senderovich, Naftalie, Shaham, Oded, Shraga, Meytal, Simon, Einav, Sommer, Lauren M., Zarchin, Oren, Carroll, Karen C., Gottlieb, Tanya M.

“…The objective was to evaluate the analytical performance of a new point-of-need platform for rapid and accurate measurement of a host-protein score that…”
Get full text

Antibiotic misuse in respiratory tract infections in children and adults—a prospective, multicentre study (TAILORED Treatment) by van Houten, Chantal B., Cohen, Asi, Engelhard, Dan, Hays, John P., Karlsson, Roger, Moore, Edward, Fernández, David, Kreisberg, Racheli, Collins, Laurence V., de Waal, Wouter, de Winter-de Groot, Karin M., Wolfs, Tom F. W., Meijers, Pieter, Luijk, Bart, Oosterheert, Jan Jelrik, Heijligenberg, Rik, Sankatsing, Sanjay U. C., Bossink, Aik W. J., Stubbs, Andrew, Stein, Michal, Reisfeld, Sharon, Klein, Adi, Rachmilevitch, Ronit, Ashkar, Jalal, Braverman, Itzhak, Kartun, Valery, Chistyakov, Irena, Bamberger, Ellen, Srugo, Isaac, Odeh, Majed, Schiff, Elad, Dotan, Yaniv, Boico, Olga, Navon, Roy, Friedman, Tom, Etshtein, Liat, Paz, Meital, Gottlieb, Tanya M., Pri-Or, Ester, Kronenfeld, Gali, Simon, Einav, Oved, Kfir, Eden, Eran, Bont, Louis J.

“…Respiratory tract infections (RTI) are more commonly caused by viral pathogens in children than in adults. Surprisingly, little is known about antibiotic use…”
Get full text

An immune-protein score combining TRAIL, IP-10 and CRP for predicting severe COVID-19 disease by Mastboim, Niv Samuel, Angel, Alon, Shaham, Oded, Ber, Tahel Ilan, Navon, Roy, Simon, Einav, Rosenberg, Michal, Israeli, Yael, Hainrichson, Mary, Avni, Noa, Reiner, Eran, Feigin, Paul, Oved, Kfir, Tadmor, Boaz, Singer, Pierre, Kagan, Ilya, Lev, Shaul, Diker, Dror, Jarjou'I, Amir, Kurd, Ramzi, Ben-Chetrit, Eli, Danziger, Guy, Tegethoff, Sina A., Papan, Cihan, Motov, Sergey, Shapira, Ma'anit, Stein, Michal, Gottlieb, Tanya M., Eden, Eran, Klein, Adi

“…•The levels of TRAIL, IP-10, and CRP are integrated into a single numeric score.•This host score is an early indicator of severe outcome for COVID-19…”
Get full text

A novel host-protein assay outperforms routine parameters for distinguishing between bacterial and viral lower respiratory tract infections by Stein, Michal, Lipman-Arens, Shelly, Oved, Kfir, Cohen, Asi, Bamberger, Ellen, Navon, Roy, Boico, Olga, Friedman, Tom, Etshtein, Liat, Paz, Meital, Gottlieb, Tanya M., Kriger, Or, Fonar, Yura, Pri-Or, Ester, Yacobov, Renata, Dotan, Yaniv, Hochberg, Amit, Grupper, Moti, Chistyakov, Irina, Potasman, Israel, Srugo, Isaac, Eden, Eran, Klein, Adi

“…Bacterial and viral lower respiratory tract infections (LRTIs) are often clinically indistinguishable, leading to antibiotic overuse. We compared the…”
Get full text

Expert panel diagnosis demonstrated high reproducibility as reference standard in infectious diseases by van Houten, Chantal B., Naaktgeboren, Christiana A., Ashkenazi-Hoffnung, Liat, Ashkenazi, Shai, Avis, Wim, Chistyakov, Irena, Corigliano, Teresa, Galetto, Annick, Gangoiti, Iker, Gervaix, Alain, Glikman, Daniel, Ivaskeviciene, Inga, Kuperman, Amir A., Lacroix, Laurence, Loeffen, Yvette, Luterbacher, Fanny, Meijssen, Clemens B., Mintegi, Santiago, Nasrallah, Basheer, Papan, Cihan, van Rossum, Annemarie M.C., Rudolph, Henriette, Stein, Michal, Tal, Roie, Tenenbaum, Tobias, Usonis, Vytautas, de Waal, Wouter, Weichert, Stefan, Wildenbeest, Joanne G., de Winter-de Groot, Karin M., Wolfs, Tom F.W., Mastboim, Niv, Gottlieb, Tanya M., Cohen, Asi, Oved, Kfir, Eden, Eran, Feigin, Paul D., Shani, Liran, Bont, Louis J.

“…If a gold standard is lacking in a diagnostic test accuracy study, expert diagnosis is frequently used as reference standard. However, interobserver and…”
Get full text

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis by GOTTLIEB, Tanya M, MARTINEZ LEAL, Juan Fernando, SEGER, Rony, TAYA, Yoichi, OREN, Moshe

“…The p53 tumor suppressor protein and the Akt/PKB kinase play important roles in the transduction of pro-apoptotic and anti-apoptotic signals, respectively. We…”
Get full text

Differential Serum and Urine CRP, IP-10, and TRAIL Levels in Pediatric Urinary Tract Infection by Ashkenazi-Hoffnung, Liat, Livni, Gilat, Scheuerman, Oded, Berger, Itay, Eden, Eran, Oved, Kfir, Shani, Liran, Kronenfeld, Gali, Simon, Einav, Boico, Olga, Navon, Roy, Gottlieb, Tanya M, Barash, Eran, Paz, Meital, Yuhas, Yael, Berent, Eva, Ashkenazi, Shai

“…It is estimated that clinical evaluation and urinalysis are unable to diagnose >10% of urinary tract infections (UTI) in young children. TNF-related apoptosis…”
Get full text

Rapid ATM-Dependent Phosphorylation of MDM2 Precedes p53 Accumulation in Response to DNA Damage by Khosravi, Rami, Maya, Ruth, Gottlieb, Tanya, Oren, Moshe, Shiloh, Yosef, Shkedy, Dganit

“…The p53 tumor-suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. This process is…”
Get full text

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation by Blunt, Tracy, Finnie, Nicholas J, Taccioli, Guillermo E, Smith, Graeme C.M, Demengeot, Jocelyne, Gottlieb, Tanya M, Mizuta, Ryushin, Varghese, A.J, Alt, Frederick W, Jeggo, Penny A, Jackson, Stephen P

“…Murine cells homozygous for the severe combined immune deficiency mutation ( scid) and V3 mutant hamster cells fall into the same complementation group and…”
Get full text

DNA-Dependent Protein Kinase Activity is Absent in xrs-6 Cells: Implications for Site-Specific Recombination and DNA Double-Strand Break Repair by Finnie, Nicholas J., Gottlieb, Tanya M., Blunt, Tracy, Jeggo, Penny A., Jackson, Stephen P.

“…DNA-dependent protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase composed of a catalytic subunit called p350 and a DNA binding component…”
Get full text

Epitope-based approaches to a universal influenza vaccine by Gottlieb, Tanya, Ben-Yedidia, Tamar

“…Abstract The development of vaccines has been one of the most important contributions of immunology to public health to date. Although several infectious…”
Get full text

Potential genetic variance and the domestication of maize by Gottlieb, Tanya M., Wade, Michael J., Rutherford, Suzanne L.

“…Since Darwin, there has been a long and arduous struggle to understand the source and maintenance of natural genetic variation and its relationship to…”
Get full text

Priming by a novel universal influenza vaccine (Multimeric-001)—A gateway for improving immune response in the elderly population by Atsmon, Jacob, Caraco, Yoseph, Ziv-Sefer, Sagit, Shaikevich, Dimitry, Abramov, Ester, Volokhov, Inna, Bruzil, Svetlana, Haima, Kirsten Y, Gottlieb, Tanya, Ben-Yedidia, Tamar

“…Highlights • Phase II clinical trial in elderly population (65+) of M-001, a broad specificity peptide-based recombinant vaccine against influenza. • M-001…”
Get full text