Search Results - "Gotthardt, D. N."

Reduction in alkaline phosphatase is associated with longer survival in primary sclerosing cholangitis, independent of dominant stenosis by Rupp, C., Rössler, A., Halibasic, E., Sauer, P., Weiss, K.‐H., Friedrich, K., Wannhoff, A., Stiehl, A., Stremmel, W., Trauner, M., Gotthardt, D. N.

“…Summary Background Alkaline phosphatase (ALP) is an important serum marker in primary sclerosing cholangitis (PSC). Patients with obstruction of the large bile…”
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Fut2 genotype is a risk factor for dominant stenosis and biliary candida infections in primary sclerosing cholangitis by Rupp, C., Friedrich, K., Folseraas, T., Wannhoff, A., Bode, K. A., Weiss, K.‐H., Schirmacher, P., Sauer, P., Stremmel, W., Gotthardt, D. N.

“…Summary Background A recent genome‐wide association study identified the FUT2 secretor status and genotype defined by the single‐nucleotide polymorphism…”
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In PSC with Colitis Treated with UDCA, Most Colonic Carcinomas Develop in the First Years After the Start of Treatment by Rudolph, G., Gotthardt, D. N., Kloeters-Plachky, P., Kulaksiz, H., Schirmacher, P., Stiehl, A.

“…Background Patients with PSC and IBD have a high incidence of colonic carcinomas (CRC), and the annual incidence of CRC increases with duration of disease…”
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Letter: cardiovascular complications in patients with transjugular intrahepatic portosystemic shunt – the necessity for regular cardiac surveillance. Authors' reply by Wannhoff, A., Gotthardt, D. N.

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Pathological features of primary sclerosing cholangitis identified by bile proteomic analysis by Rupp, C., Bode, K.A., Leopold, Y., Sauer, P., Gotthardt, D.N.

“…Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown origin. Previous bile proteomic analyses in patients with PSC have…”
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Editorial: cardiac volume overload and pulmonary hypertension in long‐term follow‐up of TIPSS patients – authors’ reply by Wannhoff, A., Hippchen, T., Gotthardt, D. N.

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Cardiac volume overload and pulmonary hypertension in long‐term follow‐up of patients with a transjugular intrahepatic portosystemic shunt by Wannhoff, A., Hippchen, T., Weiss, C. S., Friedrich, K., Rupp, C., Neumann‐Haefelin, C., Dollinger, M., Antoni, C., Stampfl, U., Schemmer, P., Stremmel, W., Weiss, K. H., Radeleff, B., Katus, H. A., Gotthardt, D. N.

“…Summary Background Transjugular intrahepatic portosystemic shunt (TIPSS) cause haemodynamic changes in patients with cirrhosis, yet little is known about…”
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Editorial: further evidence for the role of serum alkaline phosphatase as a useful surrogate marker of prognosis in PSC – authors' reply by Rupp, C., Stiehl, A., Trauner, M., Gotthardt, D. N.

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Comment re: “Optimize CA19-9 in detecting pancreatic cancer by Lewis and Secretor genotyping” by Wannhoff, A, Weiss, K.H, Hackert, T, Gotthardt, D.N

“…Genotyping for FUT2 and FUT3 as well as CA19-9 measurement was performed in samples from 50 patients with chronic pancreatitis (control group) and 51 patients…”
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HLA haplotypes in primary sclerosing cholangitis patients of admixed and non‐European ancestry by Henriksen, E. K. K., Viken, M. K., Wittig, M., Holm, K., Folseraas, T., Mucha, S., Melum, E., Hov, J. R., Lazaridis, K. N., Juran, B. D., Chazouillères, O., Färkkilä, M., Gotthardt, D. N., Invernizzi, P., Carbone, M., Hirschfield, G. M., Rushbrook, S. M., Goode, E., Ponsioen, C. Y., Weersma, R. K., Eksteen, B., Yimam, K. K., Gordon, S. C., Goldberg, D., Yu, L., Bowlus, C. L., Franke, A., Lie, B. A., Karlsen, T. H.

“…Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and…”
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Expert recommendations: Hepatitis C and transplantation by Zimmermann, T, Beckebaum, S, Berg, C, Berg, T, Braun, F, Eurich, D, Herzer, K, Neumann, U, Rupp, C, Sterneck, M, Strassburg, C, Welker, M-W, Zachoval, R, Gotthardt, D N, Weigand, K, Schmidt, H, Wedemeyer, H, Galle, P R, Zeuzem, S, Sarrazin, C

“…With the approval of new direct acting antiviral agents (DAA), therapeutic options for patients with chronic hepatitis C virus (HCV) infection are now…”
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Complication management after liver transplantation. Increasing patient safety by standardized approach and interdisciplinary cooperation by Houben, P, Gotthardt, D N, Radeleff, B, Sauer, P, Büchler, M W, Schemmer, P

“…The interdisciplinary management of postoperative complications in liver transplantation is of extreme importance. Due to organ shortage and prioritization of…”
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Methanobactin reverses acute liver failure in a rat model of Wilson disease by Lichtmannegger, Josef, Leitzinger, Christin, Wimmer, Ralf, Schmitt, Sabine, Schulz, Sabine, Kabiri, Yaschar, Eberhagen, Carola, Rieder, Tamara, Janik, Dirk, Neff, Frauke, Straub, Beate K, Schirmacher, Peter, DiSpirito, Alan A, Bandow, Nathan, Baral, Bipin S, Flatley, Andrew, Kremmer, Elisabeth, Denk, Gerald, Reiter, Florian P, Hohenester, Simon, Eckardt-Schupp, Friedericke, Dencher, Norbert A, Adamski, Jerzy, Sauer, Vanessa, Niemietz, Christoph, Schmidt, Hartmut H J, Merle, Uta, Gotthardt, Daniel Nils, Kroemer, Guido, Weiss, Karl Heinz, Zischka, Hans

“…In Wilson disease (WD), functional loss of ATPase copper-transporting β (ATP7B) impairs biliary copper excretion, leading to excessive copper accumulation in…”
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Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci by Folseraas, Trine, Melum, Espen, Rausch, Philipp, Juran, Brian D, Ellinghaus, Eva, Shiryaev, Alexey, Laerdahl, Jon K, Ellinghaus, David, Schramm, Christoph, Weismüller, Tobias J, Gotthardt, Daniel Nils, Hov, Johannes Roksund, Clausen, Ole Petter, Weersma, Rinse K, Janse, Marcel, Boberg, Kirsten Muri, Björnsson, Einar, Marschall, Hanns-Ulrich, Cleynen, Isabelle, Rosenstiel, Philip, Holm, Kristian, Teufel, Andreas, Rust, Christian, Gieger, Christian, Wichmann, H-Erich, Bergquist, Annika, Ryu, Euijung, Ponsioen, Cyriel Y, Runz, Heiko, Sterneck, Martina, Vermeire, Severine, Beuers, Ulrich, Wijmenga, Cisca, Schrumpf, Erik, Manns, Michael P, Lazaridis, Konstantinos N, Schreiber, Stefan, Baines, John F, Franke, Andre, Karlsen, Tom H

“…Background & Aims A limited number of genetic risk factors have been reported in primary sclerosing cholangitis (PSC). To discover further genetic…”
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Genome‐wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4 by Ellinghaus, David, Folseraas, Trine, Holm, Kristian, Ellinghaus, Eva, Melum, Espen, Balschun, Tobias, Laerdahl, Jon K., Shiryaev, Alexey, Gotthardt, Daniel N., Weismüller, Tobias J., Schramm, Christoph, Wittig, Michael, Bergquist, Annika, Björnsson, Einar, Marschall, Hanns‐Ulrich, Vatn, Morten, Teufel, Andreas, Rust, Christian, Gieger, Christian, Wichmann, H‐Erich, Runz, Heiko, Sterneck, Martina, Rupp, Christian, Braun, Felix, Weersma, Rinse K., Wijmenga, Cisca, Ponsioen, Cyriel Y., Mathew, Christopher G., Rutgeerts, Paul, Vermeire, Séverine, Schrumpf, Erik, Hov, Johannes R., Manns, Michael P., Boberg, Kirsten M., Schreiber, Stefan, Franke, Andre, Karlsen, Tom H.

“…Approximately 60%‐80% of patients with primary sclerosing cholangitis (PSC) have concurrent ulcerative colitis (UC). Previous genome‐wide association studies…”
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Endoscopic dilation of dominant stenoses in primary sclerosing cholangitis: outcome after long-term treatment by Gotthardt, Daniel N., MD, Rudolph, Gerda, Klöters-Plachky, Petra, Kulaksiz, Hasan, MD, Stiehl, Adolf, MD

“…Background Primary sclerosing cholangitis is characterized by progressive fibrotic inflammation and obliteration of intra- and/or extrahepatic bile ducts…”
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Genotype-phenotype analysis across 130 422 genetic variants identifies RSPO3 as the first genome-wide significant modifier gene in primary sclerosing cholangitis by Alberts, R, de Vries, EM, Alexander, G, Alvaro, D, Bergquist, A, Beuers, U, Bjornsson, E, Boberg, KM, Bowlus, CL, Chapman, RW, Chazouilleres, O, Cheung, A, Dalekos, G, Eksteen, B, Ellinghaus, D, Farkkila, M, Festen, EA, Floreani, A, Folseraas, T, Goode, E, Gotthardt, DN, Hirschfield, GM, van Hoek, B, Holm, K, Hohenester, S, Hov, JR, Imhann, F, Invernizzi, P, Jiang, X, Eaton, J, Juran, BD, Lazaridis, KN, Leppa, V, Liu, JZ, Lofberg, J, Manns, MP, Marschall, HU, Marzioni, M, Mason, AL, Melum, E, Milkiewicz, P, Muller, T, Pares, A, Rupp, C, Rushbrook, SM, Rust, C, Sampaziotis, F, Sandford, RN, Schramm, C, Schreiber, S, Schrumpf, E, Silverberg, M, Srivastava, B, Sterneck, M, Teufel, A, Tittmann, L, Vallier, L, Vila, AV, de Vries, B, Weismuller, TJ, Wijmenga, C, Zachou, K, Franke, A, Anderson, CA, Karlsen, TH, Ponsioen, CY, Weersma, RK

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Komplikationsmanagement nach Lebertransplantation: Erhöhung der Patientensicherheit durch standardisiertes Vorgehen und interdisziplinäre Kooperation by Houben, P., Gotthardt, D.N., Radeleff, B., Sauer, P., Büchler, M.W., Schemmer, P.

“…Zusammenfassung Nach Lebertransplantation ist das interdisziplinäre Komplikationsmanagement von großer Bedeutung. Unter dem Gesichtspunkt der derzeit…”
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PRIMARY SCLEROSING CHOLANGITIS FROM A GLOBAL PERSPECTIVE - A MULTICENTER, RETROSPECTIVE, OBSERVATIONAL STUDY OF THE INTERNATIONAL PSC STUDY GROUP by Weismuller, TJ, Talwalkar, JA, Ponsioen, CY, Gotthardt, DN, Marschall, HU, Naess, S, Holm, K, Weersma, RK, Lazaridis, KN, Fevery, J, Trivedi, PJ, Schramm, C, Chazouilleres, O, Muller, T, Farkkila, M, Almer, S, Pereira, S, Mason, AL, Floreani, A, Milkiewicz, P, Harley, H, Pares, A, de Vries, L, Manser, C, Gatselis, N, Berg, C, Lenzen, H, de Valle, MB, Imam, M, Kirchner, G, de Leuw, P, Zimmer, V, Fabris, L, Braun, F, Hirschfield, GM, Marzioni, M, Juran, BD, Strassburg, CP, Beuers, U, Manns, MP, Schrumpf, E, Karlsen, TH, Bergquist, A, Boberg, KM

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