Search Results - "Gottgens, B."

Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia by Sive, J I, Basilico, S, Hannah, R, Kinston, S J, Calero-Nieto, F J, Göttgens, B

“…Transcriptional dysregulation is associated with haematological malignancy. Although mutations of the key haematopoietic transcription factor PU.1 are rare in…”
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BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms by Wyspiańska, B S, Bannister, A J, Barbieri, I, Nangalia, J, Godfrey, A, Calero-Nieto, F J, Robson, S, Rioja, I, Li, J, Wiese, M, Cannizzaro, E, Dawson, M A, Huntly, B, Prinjha, R K, Green, A R, Gottgens, B, Kouzarides, T

“…Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in…”
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Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis by Lohoff, T., Ghazanfar, S., Missarova, A., Koulena, N., Pierson, N., Griffiths, J. A., Bardot, E. S., Eng, C.-H. L., Tyser, R. C. V., Argelaguet, R., Guibentif, C., Srinivas, S., Briscoe, J., Simons, B. D., Hadjantonakis, A.-K., Göttgens, B., Reik, W., Nichols, J., Cai, L., Marioni, J. C.

“…Molecular profiling of single cells has advanced our knowledge of the molecular basis of development. However, current approaches mostly rely on dissociating…”
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HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias by Calero-Nieto, F J, Joshi, A, Bonadies, N, Kinston, S, Chan, W-I, Gudgin, E, Pridans, C, Landry, J-R, Kikuchi, J, Huntly, B J, Gottgens, B

“…The Lim Domain Only 2 ( LMO2 ) leukaemia oncogene encodes an LIM domain transcriptional cofactor required for early haematopoiesis. During embryogenesis, LMO2…”
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Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In Vivo by Delabesse, E., Ogilvy, S., Chapman, M. A., Piltz, S. G., Gottgens, B., Green, A. R.

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Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors by Göttgens, Berthold, Nastos, Aristotelis, Kinston, Sarah, Piltz, Sandie, Delabesse, Eric C.M., Stanley, Maureen, Sanchez, Maria-Jose, Ciau-Uitz, Aldo, Patient, Roger, Green, Anthony R.

“…Stem cells are a central feature of metazoan biology. Haematopoietic stem cells (HSCs) represent the best‐characterized example of this phenomenon, but the…”
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Delineating MEIS1 cis-regulatory elements active in hematopoietic cells by Xiang, P, Wei, W, Lo, C, Rosten, P, Hou, J, Hoodless, P A, Bilenky, M, Bonifer, C, Cockerill, P N, Kirkpatrick, A, Gottgens, B, Hirst, M, Humphries, K R

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A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification by Edginton-White, B., Maytum, A., Kellaway, S. G., Goode, D. K., Keane, P., Pagnuco, I., Assi, S. A., Ames, L., Clarke, M., Cockerill, P. N., Göttgens, B., Cazier, J. B., Bonifer, C.

“…Developmental control of gene expression critically depends on distal cis-regulatory elements including enhancers which interact with promoters to activate…”
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The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia by Giotopoulos, G, Chan, W-I, Horton, S J, Ruau, D, Gallipoli, P, Fowler, A, Crawley, C, Papaemmanuil, E, Campbell, P J, Göttgens, B, Van Deursen, J M, Cole, P A, Huntly, B J P

“…Growing evidence links abnormal epigenetic control to the development of hematological malignancies. Accordingly, inhibition of epigenetic regulators is…”
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TFBScluster: a resource for the characterization of transcriptional regulatory networks by Donaldson, Ian John, Chapman, Michael, Göttgens, Berthold

“…One major challenge of the post-sequencing era of the human genome project will be the functional annotation of the non-coding portion of the genome, in…”
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Analysis of vertebrate SCL loci identifies conserved enhancers by Green, Anthony R, Göttgens, Berthold, Barton, Linda M, Gilbert, James G.R, Bench, Anthony J, Sanchez, Maria-José, Bahn, Sabine, Mistry, Shailesh, Grafham, Darren, McMurray, Amanda, Vaudin, Mark, Amaya, Enrique, Bentley, David R

“…The SCL gene encodes a highly conserved bHLH transcription factor with a pivotal role in hemopoiesis and vasculogenesis. We have sequenced and analyzed 320 kb…”
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Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences by Göttgens, B, Gilbert, J G, Barton, L M, Grafham, D, Rogers, J, Bentley, D R, Green, A R

“…Long-range comparative sequence analysis provides a powerful strategy for identifying conserved regulatory elements. The stem cell leukemia (SCL) gene encodes…”
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Combining single-cell tracking and omics improves blood stem cell fate regulator identification by Wehling, A., Loeffler, D., Zhang, Y., Kull, T., Donato, C., Szczerba, B., Camargo Ortega, G., Lee, M., Moor, A., Göttgens, B., Aceto, N., Schroeder, T.

“…Molecular programs initiating cell fate divergence (CFD) are difficult to identify. Current approaches usually compare cells long after CFD initiation,…”
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Lineage-Restricted Regulation of the Murine SCL/TAL-1 Promoter by Bockamp, E.-O., McLaughlin, F., Murrell, A.M., Gottgens, B., Robb, L, Begley, C.G., Green, A.R.

“…The SCL/TAL-1 gene encodes a basic helix-loop-helix transcription factor that is expressed in multipotent hematopoietic progenitors before lineage commitment…”
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PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells by Wolf, F Alexander, Hamey, Fiona K, Plass, Mireya, Solana, Jordi, Dahlin, Joakim S, Göttgens, Berthold, Rajewsky, Nikolaus, Simon, Lukas, Theis, Fabian J

“…Single-cell RNA-seq quantifies biological heterogeneity across both discrete cell types and continuous cell transitions. Partition-based graph abstraction…”
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The SCL +40 Enhancer Targets the Midbrain Together with Primitive and Definitive Hematopoiesis and Is Regulated by SCL and GATA Proteins by Ogilvy, S., Ferreira, R., Piltz, S. G., Bowen, J. M., Göttgens, B., Green, A. R.

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P1416: DNA DAMAGE TRIGGERS A P53 INDUCED AGEING RESPONSE IN HAEMATOPOIETIC STEM CELLS by Wang, M., Brandt, L., Wang, X., Garaycoechea, J., Wilson, N., Göttgens, B., Patel, K. J.

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The SCL gene specifies haemangioblast development from early mesoderm by Gering, M., Rodaway, A.R.F., Göttgens, B., Patient, R.K., Green, A.R.

“…The SCL gene encodes a basic helix–loop–helix (bHLH) transcription factor that is essential for the development of all haematopoietic lineages. SCL is also…”
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Two classes of homeodomain proteins specify the multiple A mating types of the mushroom Coprinus cinereus by Kues, U. (University of Oxford, Oxford, United Kingdom), Asante-Owusu, R.N, Mutasa, E.S, Tymon, A.M, Pardo, E.H, O'Shea, S.F, Gottgens, B, Casselton, L.A

“…The A mating type locus of the mushroom Coprinus cinereus regulates essential steps in sexual development. The locus is complex and contains several…”
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An N-terminal dimerization domain permits homeodomain proteins to choose compatible partners and initiate sexual development in the mushroom Coprinus cinereus by Banham, A.H. (University of Oxford, Oxford, UK.), Asante-Owusu, R.N, Gottgens, B, Thompson, S.A.J, Kingsnorth, C.S, Mellor, E.J.C, Casselton, L.A

“…The A mating-type locus of the mushroom Coprinus cinereus contains three or more paralogous pairs of genes encoding two families of homeodomain proteins (HD1…”
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