Search Results - "Gottesman, M E"

Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK by Zhu, Xiaotian, Zhao, Xun, Burkholder, William F., Gragerov, Alexander, Ogata, Craig M., Gottesman, Max E., Hendrickson, Wayne A.

“…DnaK and other members of the 70-kilodalton heat-shock protein (hsp70) family promote protein folding, interaction, and translocation, both constitutively and…”
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Disruption of the Transthyretin Gene Results in Mice with Depressed Levels of Plasma Retinol and Thyroid Hormone by Episkopou, Vasso, Maeda, Shuichiro, Nishiguchi, Seiji, Shimada, Kazunori, Gaitanaris, George A., Gottesman, Max E., Robertson, Elizabeth J.

“…Transthyretin (TTR) is thought to play a major role in vitamin A metabolism and thyroid hormone transport in mammals. To investigate the physiological role of…”
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Diethylnitrosamine-induced hepatocarcinogenesis is suppressed in lecithin:retinol acyltransferase-deficient mice primarily through retinoid actions immediately after carcinogen administration by Shirakami, Yohei, Gottesman, Max E., Blaner, William S.

“…Loss of retinoid-containing lipid droplets upon hepatic stellate cell (HSC) activation is one of the first events in the development of liver disease leading…”
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Cooperation of GroEL/GroES and DnaK/DnaJ Heat Shock Proteins in Preventing Protein Misfolding in Escherichia coli by Gragerov, Alexander, Nudler, Evgeny, Komissarova, Natalia, Gaitanaris, George A., Gottesman, Max E., Nikiforov, Vadim

“…Newly synthesized proteins aggregate extensively in Escherichia coli rpoH mutants, which are deficient in the heat shock proteins (hsp). Overproduction of…”
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Specificity of DnaK-peptide binding by Gragerov, A, Zeng, L, Zhao, X, Burkholder, W, Gottesman, M E

“…The sequence specificity of DnaK substrate binding has been studied using a peptide display library. Based on the amino acid patterns that appeared in this…”
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Analysis of amyloid deposition in a transgenic mouse model of homozygous familial amyloidotic polyneuropathy by Kohno, K, Palha, JA, Miyakawa, K, Saraiva, MJ, Ito, S, Mabuchi, T, Blaner, WS, Iijima, H, Tsukahara, S, Episkopou, V, Gottesman, ME, Shimada, K, Takahashi, K, Yamamura, K, Maeda, S

“…Amyloid fibrils derived from the Japanese, Portuguese, and Swedish types of familial amyloidotic polyneuropathy all consist of a variant transthyretin (TTR)…”
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Escherichia coli NusG protein stimulates transcription elongation rates in vivo and in vitro by Burova, E, Hung, S C, Sagitov, V, Stitt, B L, Gottesman, M E

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Requirement for cAMP-PKA Pathway Activation by M Phase-Promoting Factor in the Transition from Mitosis to Interphase by Grieco, Domenico, Porcellini, Antonio, Avvedimento, Enrico V., Gottesman, Max E.

“…Cell cycle progression in cycling Xenopus egg extracts is accompanied by fluctuations in the concentration of adenosine 3′,5′-monophosphate (cAMP) and in the…”
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Transthyretin is not essential for thyroxine to reach the brain and other tissues in transthyretin-null mice by Palha, J A, Hays, M T, Morreale de Escobar, G, Episkopou, V, Gottesman, M E, Saraiva, M J

“…As part of a study on tissue uptake of thyroxine (T4) in a transthyretin (TTR)-null mouse strain, kinetic parameters of thyroxine metabolism in wild-type mice…”
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Mechanism of retinoic acid-induced transcription: histone code, DNA oxidation and formation of chromatin loops by Zuchegna, C., Aceto, F., Bertoni, A., Romano, A., Perillo, B., Laccetti, P., Gottesman, M. E., Avvedimento, E. V., Porcellini, A.

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Translation of the prophage lambda cl transcript by Shean, C S, Gottesman, M E

“…Mutations in rpsB that reduce the levels of the ribosomal protein S2 enhance the translation of cl in lambda lysogens. Two features of the cl transcript are…”
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The biological functions of A-kinase anchor proteins by Feliciello, A, Gottesman, M E, Avvedimento, E V

“…cAMP-dependent protein kinase is targeted to discrete subcellular locations by a family of specific anchor proteins (A-kinase anchor proteins, AKAPs)…”
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Mutations in the C-Terminal Fragment of DnaK Affecting Peptide Binding by Burkholder, William F., Zhao, Xun, Zhu, Xiaotian, Hendrickson, Wayne A., Gragerov, Alexander, Gottesman, Max E.

“…Escherichia coli DnaK acts as a molecular chaperone through its ATP-regulated binding and release of polypeptide substrates. Overexpressing a C-terminal…”
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Binding of Transcription Termination Protein Nun to Nascent RNA and Template DNA by Watnick, Randolph S., Gottesman, Max E.

“…The amino-terminal arginine-rich motif of coliphage HK022 Nun binds phage λ nascent transcript, whereas the carboxyl-terminal domain interacts with RNA…”
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Effect of Escherichia coli nusG function on lambda N-mediated transcription antitermination by SULLIVAN, S. L, WARD, D. F, GOTTESMAN, M. E

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Sequence and transcriptional pattern of the essential Escherichia coli secE-nusG operon by Downing, W L, Sullivan, S L, Gottesman, M E, Dennis, P P

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v-Ras and protein kinase C dedifferentiate thyroid cells by down-regulating nuclear cAMP-dependent protein kinase A by GALLO, A, BENUSIGLIO, E, BONAPACE, I. M, FELICIELLO, A, CASSANO, S, GARBI, C, MUSTI, A. M, GOTTESMAN, M. E, AVVEDIMENTO, E. V

“…Ras proteins are membrane-associated transducers of eternal stimuli to unknown intracellular targets. The constitutively activated v-ras oncogene induces…”
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Thyroid hormone metabolism in a transthyretin-null mouse strain by Palha, J A, Episkopou, V, Maeda, S, Shimada, K, Gottesman, M E, Saraiva, M J

“…Transthyretin (TTR) is the principal carrier of thyroid hormones in rodent plasma and the major protein synthesized by the choroid plexus. Mice lacking TTR…”
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Serum amyloid P component enhances induction of murine amyloidosis by Togashi, S, Lim, S K, Kawano, H, Ito, S, Ishihara, T, Okada, Y, Nakano, S, Kinoshita, T, Horie, K, Episkopou, V, Gottesman, M E, Costantini, F, Shimada, K, Maeda, S

“…Serum amyloid P component (SAP), a common component of all known types of amyloid fibrils, protects amyloid fibrils from proteolysis in vitro. It is therefore…”
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Resistance of lambda cI translation to antibiotics that inhibit translation initiation by CHIN, K, SHEAN, C. S, GOTTESMAN, M. E

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