Search Results - "Gottesman, I I"

Psychiatric endophenotypes and the development of valid animal models by Gould, T. D., Gottesman, I. I.

“…Endophenotypes are quantifiable components in the genes‐to‐behaviors pathways, distinct from psychiatric symptoms, which make genetic and biological studies of…”
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Deconstructing Schizophrenia: An Overview of the Use of Endophenotypes in Order to Understand a Complex Disorder by Braff, David L., Freedman, Robert, Schork, Nicholas J., Gottesman, Irving I.

“…The genetics of schizophrenia has been approached utilizing a variety of methods. One emerging strategy is the use of endophenotypes in order to understand and…”
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Oxytocin enhances observational fear in mice by Pisansky, Marc T., Hanson, Leah R., Gottesman, Irving I., Gewirtz, Jonathan C.

“…Empathy is fundamental to human relations, but its neural substrates remain largely unknown. Here we characterize the involvement of oxytocin in the capacity…”
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The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies? by Courtet, P, Gottesman, I I, Jollant, F, Gould, T D

“…Vulnerability to suicidal behavior (SB) is likely mediated by an underlying genetic predisposition interacting with environmental and probable epigenetic…”
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The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions by Gottesman, Irving I., Gould, Todd D.

“…Endophenotypes, measurable components unseen by the unaided eye along the pathway between disease and distal genotype, have emerged as an important concept in…”
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Animal models to improve our understanding and treatment of suicidal behavior by Gould, T D, Georgiou, P, Brenner, L A, Brundin, L, Can, A, Courtet, P, Donaldson, Z R, Dwivedi, Y, Guillaume, S, Gottesman, I I, Kanekar, S, Lowry, C A, Renshaw, P F, Rujescu, D, Smith, E G, Turecki, G, Zanos, P, Zarate, C A, Zunszain, P A, Postolache, T T

“…Worldwide, suicide is a leading cause of death. Although a sizable proportion of deaths by suicide may be preventable, it is well documented that despite major…”
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Brain connectivity and gyrification as endophenotypes for schizophrenia: weight of the evidence by White, T, Gottesman, I

“…The tremendous heterogeneity in the clinical symptoms and cognitive/emotional deficits seen in patients with schizophrenia has made it challenging to determine…”
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Toward Constructing an Endophenotype Strategy for Bipolar Disorders by Hasler, Gregor, Drevets, Wayne C., Gould, Todd D., Gottesman, Irving I., Manji, Husseini K.

“…Research aimed at elucidating the underlying neurobiology and genetics of bipolar disorder, and factors associated with treatment response, have been limited…”
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Using summary data from the danish national registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorder by Wray, Naomi R, Gottesman, Irving I

“…Estimates of heritability of psychiatric disorders quantify the genetic contribution to their etiology. Estimation of these parameters requires affected status…”
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Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance? by Petronis, Arturas, Gottesman, Irving I, Kan, Peixiang, Kennedy, James L, Basile, Vincenzo S, Paterson, Andrew D, Popendikyte, Violeta

“…The goal of this pilot study was to explore the putative molecular mechanisms underlying the phenotypic discordance of monozygotic (MZ) twins. Thus, patterns…”
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Arguments for the sake of endophenotypes: Examining common misconceptions about the use of endophenotypes in psychiatric genetics by Glahn, David C., Knowles, Emma E.M., McKay, D. Reese, Sprooten, Emma, Raventós, Henriette, Blangero, John, Gottesman, Irving I, Almasy, Laura

“…Endophenotypes are measurable biomarkers that are correlated with an illness, at least in part, because of shared underlying genetic influences. Endophenotypes…”
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DNA methylation profiles in monozygotic and dizygotic twins by Petronis, Art, Kaminsky, Zachary A, Tang, Thomas, Wang, Sun-Chong, Ptak, Carolyn, Oh, Gabriel H T, Wong, Albert H C, Feldcamp, Laura A, Virtanen, Carl, Halfvarson, Jonas, Tysk, Curt, McRae, Allan F, Visscher, Peter M, Montgomery, Grant W, Gottesman, Irving I, Martin, Nicholas G

“…Twin studies have provided the basis for genetic and epidemiological studies in human complex traits. As epigenetic factors can contribute to phenotypic…”
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Attention, Memory, and Motor Skills as Childhood Predictors of Schizophrenia-Related Psychoses: The New York High-Risk Project by Erlenmeyer-Kimling, L., Rock, Donald, Roberts, Simone A., Janal, Malvin, Kestenbaum, Clarice, Cornblatt, Barbara, Adamo, Ulla Hilldoff, Gottesman, Irving I.

“…OBJECTIVE: Childhood neurobehavioral deficits in offspring of schizophrenic, affectively ill, and psychiatrically normal parents were evaluated as predictors…”
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Mice lacking the chromodomain helicase DNA-binding 5 chromatin remodeler display autism-like characteristics by Pisansky, M T, Young, A E, O'Connor, M B, Gottesman, I I, Bagchi, A, Gewirtz, J C

“…Although autism spectrum disorders (ASDs) share a core set of nosological features, they exhibit substantial genetic heterogeneity. A parsimonious hypothesis…”
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Impact of depression on quality-adjusted life expectancy (QALE) directly as well as indirectly through suicide by Jia, Haomiao, Zack, Matthew M., Thompson, William W., Crosby, Alex E., Gottesman, Irving I.

“…Purpose To estimate quality-adjusted life expectancy (QALE) loss among US adults due to depression and QALE losses associated with the increased risk of…”
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Human development: Biological and genetic processes by GOTTESMAN, Irving I, HANSON, Daniel R

“…Adaptation is a central organizing principle throughout biology, whether we are studying species, populations, or individuals. Adaptation in biological systems…”
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Phenotypic differences in genetically identical organisms: the epigenetic perspective by Wong, Albert H.C., Gottesman, Irving I., Petronis, Arturas

“…Human monozygotic twins and other genetically identical organisms are almost always strikingly similar in appearance, yet they are often discordant for…”
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Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star? by Chan, Raymond C.K., Gottesman, Irving I.

“…The crucial role of neurological indicators in schizophrenia has been recognized as among the “target features” that encompass the idea that genetic and…”
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Socioeconomic Status Modifies Heritability of IQ in Young Children by Turkheimer, Eric, Haley, Andreana, Waldron, Mary, D'Onofrio, Brian, Gottesman, Irving I.

“…Scores on the Wechsler Intelligence Scale for Children were analyzed in a sample of 7-year-old twins from the National Collaborative Perinatal Project. A…”
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Lithium's Antisuicidal Efficacy : Elucidation of Neurobiological Targets Using Endophenotype Strategies by KOVACSICS, Colleen E, GOTTESMAN, Irving I, GOULD, Todd D

“…Lithium used as a drug treatment for major mental disorders such as bipolar disorder and depression is effective in reducing the risk of both attempted and…”
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