Search Results - "Gotter, Anthony"

The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia by Coleman, Paul J, Gotter, Anthony L, Herring, W. Joseph, Winrow, Christopher J, Renger, John J

“…Historically, pharmacological therapies have used mechanisms such as γ-aminobutyric acid A (GABA A ) receptor potentiation to drive sleep through broad…”
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Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors by Yin, Jie, Babaoglu, Kerim, Brautigam, Chad A, Clark, Lindsay, Shao, Zhenhua, Scheuermann, Thomas H, Harrell, Charles M, Gotter, Anthony L, Roecker, Anthony J, Winrow, Christopher J, Renger, John J, Coleman, Paul J, Rosenbaum, Daniel M

“…Human orexin receptors (hOX 1 R and hOX 2 R) are GPCRs involved in sleep regulation. Structures of hOX 1 R bound to a selective antagonist or to a dual…”
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International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology by Gotter, Anthony L, Webber, Andrea L, Coleman, Paul J, Renger, John J, Winrow, Christopher J

“…Orexin signaling is essential for normal regulation of arousal and behavioral state control and represents an attractive target for therapeutics combating…”
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Orexin 2 receptor regulation of the hypothalamic-pituitary-adrenal (HPA) response to acute and repeated stress by Grafe, Laura A, Eacret, Darrell, Luz, Sandra, Gotter, Anthony L, Renger, John J, Winrow, Chris J, Bhatnagar, Seema

“…Highlights • Orexin activation and levels in csf decrease throughout repeated restraint. • OX2 R promotes HPA response to acute stress. • When orexin levels…”
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Orexin signaling during social defeat stress influences subsequent social interaction behaviour and recognition memory by Eacret, Darrell, Grafe, Laura A., Dobkin, Jane, Gotter, Anthony L., Renger, John J., Winrow, Christopher J., Bhatnagar, Seema

“…•Orexins were stimulated via DREADDs during repeated social defeat.•This stimulation produced a passive coping phenotype and deficits in social interaction and…”
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The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold by Gotter, Anthony L, Winrow, Christopher J, Brunner, Joseph, Garson, Susan L, Fox, Steven V, Binns, Jacquelyn, Harrell, Charles M, Cui, Donghui, Yee, Ka Lai, Stiteler, Mark, Stevens, Joanne, Savitz, Alan, Tannenbaum, Pamela L, Tye, Spencer J, McDonald, Terrence, Yao, Leon, Kuduk, Scott D, Uslaner, Jason, Coleman, Paul J, Renger, John J

“…Drugs targeting insomnia ideally promote sleep throughout the night, maintain normal sleep architecture, and are devoid of residual effects associated with…”
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Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study by van den Berg, Leonard H, Rothstein, Jeffrey D, Shaw, Pamela J, Babu, Suma, Benatar, Michael, Bucelli, Robert C, Genge, Angela, Glass, Jonathan D, Hardiman, Orla, Libri, Vincenzo, Mobach, Theodore, Oskarsson, Björn, Pattee, Gary L, Ravits, John, Shaw, Christopher E, Weber, Markus, Zinman, Lorne, Jafar-nejad, Paymaan, Rigo, Frank, Lin, Luan, Ferguson, Toby A, Gotter, Anthony L, Graham, Danielle, Monine, Michael, Inra, Jennifer, Sinks, Susie, Eraly, Satish, Garafalo, Steve, Fradette, Stephanie

“…Hexanucleotide repeat expansion of C9orf72 is a common genetic cause of amyotrophic lateral sclerosis (ALS). No C9orf72-targeted treatments are available…”
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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man by Gotter, Anthony L., Forman, Mark S., Harrell, Charles M., Stevens, Joanne, Svetnik, Vladimir, Yee, Ka Lai, Li, Xiaodong, Roecker, Anthony J., Fox, Steven V., Tannenbaum, Pamela L., Garson, Susan L., Lepeleire, Inge De, Calder, Nicole, Rosen, Laura, Struyk, Arie, Coleman, Paul J., Herring, W. Joseph, Renger, John J., Winrow, Christopher J.

“…Orexin neuropeptides regulate sleep/wake through orexin receptors (OX 1 R, OX 2 R); OX 2 R is the predominant mediator of arousal promotion. The potential for…”
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Orexin receptors as therapeutic drug targets by Gotter, Anthony L, Roecker, Anthony J, Hargreaves, Richard, Coleman, Paul J, Winrow, Christopher J, Renger, John J

“…Orexin (hypocretin) receptor antagonists stand as a model for the development of targeted CNS small-molecule therapeutics. The identification of mutations in…”
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Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys by Tannenbaum, Pamela L, Tye, Spencer J, Stevens, Joanne, Gotter, Anthony L, Fox, Steven V, Savitz, Alan T, Coleman, Paul J, Uslaner, Jason M, Kuduk, Scott D, Hargreaves, Richard, Winrow, Christopher J, Renger, John J

“…In addition to enhancing sleep onset and maintenance, a desirable insomnia therapeutic agent would preserve healthy sleep's ability to wake and respond to…”
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Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia by Winrow, Christopher J., Gotter, Anthony L., Cox, Christopher D., Tannenbaum, Pamela L., Garson, Susan L., Doran, Scott M., Breslin, Michael J., Schreier, John D., Fox, Steven V., Harrell, Charles M., Stevens, Joanne, Reiss, Duane R., Cui, Donghui, Coleman, Paul J., Renger, John J.

“…Orexin (hypocretin) neuropeptides promote wakefulness by signaling through two G-protein coupled receptors, Orexin 1 Receptor (OX 1R) and Orexin 2 Receptor (OX…”
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Mammalian TIMELESS and Tipin are Evolutionarily Conserved Replication Fork-associated Factors by Gotter, Anthony L., Suppa, Christine, Emanuel, Beverly S.

“…The function of the mammalian TIMELESS protein (TIM) has been enigmatic. TIM is essential for early embryonic development, but little is known regarding its…”
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Promotion of Sleep by Suvorexant-A Novel Dual Orexin Receptor Antagonist by Winrow, Christopher J., Gotter, Anthony L., Cox, Christopher D., Doran, Scott M., Tannenbaum, Pamela L., Breslin, Michael J., Garson, Susan L., Fox, Steven V., Harrell, Charles M., Stevens, Joanne, Reiss, Duane R., Cui, Donghui, Coleman, Paul J., Renger, John J.

“…Orexins/hypocretins are key neuropeptides responsible for regulating central arousal and reward circuits. Two receptors respond to orexin signaling, orexin 1…”
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Timeless links replication termination to mitotic kinase activation by Dheekollu, Jayaraju, Wiedmer, Andreas, Hayden, James, Speicher, David, Gotter, Anthony L, Yen, Tim, Lieberman, Paul M

“…The mechanisms that coordinate the termination of DNA replication with progression through mitosis are not completely understood. The human Timeless protein…”
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Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators by Gotter, Anthony L, Garson, Susan L, Stevens, Joanne, Munden, Regina L, Fox, Steven V, Tannenbaum, Pamela L, Yao, Lihang, Kuduk, Scott D, McDonald, Terrence, Uslaner, Jason M, Tye, Spencer J, Coleman, Paul J, Winrow, Christopher J, Renger, John J

“…The current standard of care for insomnia includes gamma-aminobutyric acid receptor A (GABAA) activators, which promote sleep as well as general central…”
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In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice by Kraus, Richard L, Li, Yuxing, Gregan, Yun, Gotter, Anthony L, Uebele, Victor N, Fox, Steven V, Doran, Scott M, Barrow, James C, Yang, Zhi-Qiang, Reger, Thomas S, Koblan, Kenneth S, Renger, John J

“…T-type calcium channels have been implicated in many behaviorally important neurophysiological processes, and altered channel activity has been linked to the…”
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Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology by Stump, Craig A., Cooke, Andrew J., Bruno, Joseph, Cabalu, Tamara D., Gotter, Anthony L., Harell, C. Meacham, Kuduk, Scott D., McDonald, Terrence P., O’Brien, Julie, Renger, John J., Williams, Peter D., Winrow, Christopher J., Coleman, Paul J.

“…[Display omitted] While a correlation between blockade of the orexin 2 receptor (OX2R) with either a dual orexin receptor antagonist (DORA) or a selective…”
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The dual orexin receptor antagonist, DORA‐22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine by Yao, Lihang, Ramirez, Andres D., Roecker, Anthony J., Fox, Steven V., Uslaner, Jason M., Smith, Sean M., Hodgson, Robert, Coleman, Paul J., Renger, John J., Winrow, Christopher J., Gotter, Anthony L.

“…Chronic insomnia is defined as a persistent difficulty with sleep initiation maintenance or non‐restorative sleep. The therapeutic standard of care for this…”
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A Timeless debate: resolving TIMʼs noncircadian roles with possible clock function by Gotter, Anthony L

“…Mammalian TIMELESS (TIM) was identified due to its sequence similarity to Drosophila TIM, an essential circadian clock protein in flies. Published literature…”
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Altered sleep and affect in the neurotensin receptor 1 knockout mouse by Fitzpatrick, Karrie, Winrow, Christopher J, Gotter, Anthony L, Millstein, Joshua, Arbuzova, Janna, Brunner, Joseph, Kasarskis, Andrew, Vitaterna, Martha H, Renger, John J, Turek, Fred W

“…Sleep and mood disorders have long been understood to have strong genetic components, and there is considerable comorbidity of sleep abnormalities and mood…”
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