Search Results - "Gottardis, Marco M."

Castration-Resistant Prostate Cancer: Locking Up the Molecular Escape Routes by ATTAR, Ricardo M, TAKIMOTO, Chris H, GOTTARDIS, Marco M

“…The understanding of the key role that androgens play on the normal and pathological physiology of the prostate guided the development of different therapies…”
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Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes by NOVOSYADLYY, Ruslan, LANN, Danielle E, KURSHAN, Naamit, MEJIA, Wilson, SANTOPIETRO, Stefania, YAKAR, Shoshana, WOOD, Teresa L, LEROITH, Derek, VIJAYAKUMAR, Archana, ROWZEE, Anne, LAZZARINO, Deborah A, FIERZ, Yvonne, CARBONI, Joan M, GOTTARDIS, Marco M, PENNISI, Patricia A, MOLINOLO, Alfredo A

“…Epidemiologic studies suggest that type 2 diabetes (T2D) increases breast cancer risk and mortality, but there is limited experimental evidence supporting this…”
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BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR by Carboni, Joan M, Wittman, Mark, Yang, Zheng, Lee, Francis, Greer, Ann, Hurlburt, Warren, Hillerman, Stephen, Cao, Carolyn, Cantor, Glenn H, Dell-John, Janet, Chen, Cliff, Discenza, Lorell, Menard, Krista, Li, Aixin, Trainor, George, Vyas, Dolatrai, Kramer, Robert, Attar, Ricardo M, Gottardis, Marco M

“…BMS-754807 is a potent and reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases (Ki, <2 nmol/L). It is currently…”
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Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithelial-to-Mesenchymal Transition Mediated by NF-κB and Snail by Kim, Hyun-Jung, Litzenburger, Beate C., Cui, Xiaojiang, Delgado, David A., Grabiner, Brian C., Lin, Xin, Lewis, Michael T., Gottardis, Marco M., Wong, Tai W., Attar, Ricardo M., Carboni, Joan M., Lee, Adrian V.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Drug safety is a barrier to the discovery and development of new androgen receptor antagonists by Foster, William R., Car, Bruce D., Shi, Hong, Levesque, Paul C., Obermeier, Mary T., Gan, Jinping, Arezzo, Joseph C., Powlin, Stephanie S., Dinchuk, Joseph E., Balog, Aaron, Salvati, Mark E., Attar, Ricardo M., Gottardis, Marco M.

“…BACKGROUND Androgen receptor (AR) antagonists are part of the standard of care for prostate cancer. Despite the almost inevitable development of resistance in…”
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HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924 by Haluska, Paul, Carboni, Joan M, TenEyck, Cynthia, Attar, Ricardo M, Hou, Xiaonan, Yu, Chunrong, Sagar, Malvika, Wong, Tai W, Gottardis, Marco M, Erlichman, Charles

“…We have reported previously the activity of the insulin-like growth factor-I (IGF-IR)/insulin receptor (InsR) inhibitor, BMS-554417, in breast and ovarian…”
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Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development by Wittman, Mark D, Carboni, Joan M, Yang, Zheng, Lee, Francis Y, Antman, Melissa, Attar, Ricardo, Balimane, Praveen, Chang, Chiehying, Chen, Cliff, Discenza, Lorell, Frennesson, David, Gottardis, Marco M, Greer, Ann, Hurlburt, Warren, Johnson, Walter, Langley, David R, Li, Aixin, Li, Jianqing, Liu, Peiying, Mastalerz, Harold, Mathur, Arvind, Menard, Krista, Patel, Karishma, Sack, John, Sang, Xiaopeng, Saulnier, Mark, Smith, Daniel, Stefanski, Kevin, Trainor, George, Velaparthi, Upender, Zhang, Guifen, Zimmermann, Kurt, Vyas, Dolatrai M

“…This report describes the biological activity, characterization, and SAR leading to 9d (BMS-754807) a small molecule IGF-1R kinase inhibitor in clinical…”
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ETV6-NTRK3―Mediated Breast Epithelial Cell Transformation Is Blocked by Targeting the IGF1R Signaling Pathway by TOGNON, Cristina E, SOMASIRI, Aruna M, SORENSEN, Poul H. B, EVDOKIMOVA, Valentina E, TRIGO, Genny, UY, Evett E, MELNYK, Nataliya, CARBONI, Joan M, GOTTARDIS, Marco M, ROSKELLEY, Calvin D, POLLAK, Michael

“…The insulin-like growth factor (IGF) 1 receptor (IGF1R) is an important therapeutic target under study in many cancers. Here, we describe a breast cancer model…”
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Molecular markers for novel therapies in neuroendocrine (carcinoid) tumors by Gilbert, Judith A, Adhikari, Laura J, Lloyd, Ricardo V, Rubin, Joseph, Haluska, Paul, Carboni, Joan M, Gottardis, Marco M, Ames, Matthew M

“…Neuroendocrine (carcinoid) tumors (NETs) are endocrine neoplasms occurring most frequently in gastrointestinal and bronchopulmonary (BP) systems. The majority…”
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Combined Inhibition of IGF-1R/IR and Src family kinases enhances antitumor effects in prostate cancer by decreasing activated survival pathways by Dayyani, Farshid, Parikh, Nila U, Varkaris, Andreas S, Song, Jian H, Moorthy, Shhyam, Chatterji, Tanushree, Maity, Sankar N, Wolfe, Adam R, Carboni, Joan M, Gottardis, Marco M, Logothetis, Christopher J, Gallick, Gary E

“…Treatment of metastatic prostate cancer (PCa) with single agents has shown only modest efficacy. We hypothesized dual inhibition of different pathways in PCa…”
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BMS-536924 Reverses IGF-IR-Induced Transformation of Mammary Epithelial Cells and Causes Growth Inhibition and Polarization of MCF7 Cells by Litzenburger, Beate C, Kim, Hyun-Jung, Kuiatse, Isere, Carboni, Joan M, Attar, Ricardo M, Gottardis, Marco M, Fairchild, Craig R, Lee, Adrian V

“…Purpose: This study aimed to test the ability of a new insulin-like growth factor receptor ( IGF-IR ) tyrosine kinase inhibitor, BMS-536924, to reverse the…”
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A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor by Emanuel, Stuart L., Engle, Linda J., Chao, Ginger, Zhu, Rong-Rong, Cao, Carolyn, Lin, Zheng, Yamniuk, Aaron P., Hosbach, Jennifer, Brown, Jennifer, Fitzpatrick, Elizabeth, Gokemeijer, Jochem, Morin, Paul, Morse, Brent A., Carvajal, Irvith M., Fabrizio, David, Wright, Martin C., Das Gupta, Ruchira, Gosselin, Michael, Cataldo, Daniel, Ryseck, Rolf P., Doyle, Michael L., Wong, Tai W., Camphausen, Raymond T., Cload, Sharon T., Marsh, H. Nicholas, Gottardis, Marco M., Furfine, Eric S.

“…Engineered domains of human fibronectin (Adnectins™) were used to generate a bispecific Adnectin targeting epidermal growth factor receptor (EGFR) and…”
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Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer by Huang, Audris, Jayaraman, Lata, Fura, Aberra, Vite, Gregory D, Trainor, George L, Gottardis, Marco M, Spires, Thomas E, Spires, Vanessa M, Rizzo, Cheryl A, Obermeier, Mary T, Elzinga, Paul A, Todderud, Gordon, Fan, Yi, Newitt, John A, Beyer, Sophie M, Zhu, Yongxin, Warrack, Bethanne M, Goodenough, Angela K, Tebben, Andrew J, Doweyko, Arthur M, Gold, David L, Balog, Aaron

“…Efforts to identify a potent, reversible, nonsteroidal CYP17A1 lyase inhibitor with good selectivity over CYP17A1 hydroxylase and CYPs 11B1 and 21A2 for the…”
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GREB1 is a novel androgen-regulated gene required for prostate cancer growth by Rae, James M., Johnson, Michael D., Cordero, Kevin E., Scheys, Joshua O., Larios, José M., Gottardis, Marco M., Pienta, Kenneth J., Lippman, Marc E.

“…BACKGROUND Gene regulated in breast cancer 1 (GREB1) is a novel estrogen‐regulated gene shown to play a pivotal role in hormone‐stimulated breast cancer…”
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Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC) by Zhang, Zhuming, Connolly, Peter J, Lim, Heng Keang, Pande, Vineet, Meerpoel, Lieven, Teleha, Christopher, Branch, Jonathan R, Ondrus, Janine, Hickson, Ian, Bush, Tammy, Luistro, Leopoldo, Packman, Kathryn, Bischoff, James R, Ibrahim, Salam, Parrett, Christopher, Chong, Yolanda, Gottardis, Marco M, Bignan, Gilles

“…Persistent androgen receptor (AR) activation drives therapeutic resistance to second-generation AR pathway inhibitors and contributes to the progression of…”
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The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer by Padmakar Darne, Chetan, Velaparthi, Upender, Saulnier, Mark, Frennesson, David, Liu, Peiying, Huang, Audris, Tokarski, John, Fura, Aberra, Spires, Thomas, Newitt, John, Spires, Vanessa M., Obermeier, Mary T., Elzinga, Paul A., Gottardis, Marco M., Jayaraman, Lata, Vite, Gregory D., Balog, Aaron

“…[Display omitted] We report herein, the discovery of BMS-737 (compound 33) as a potent, non-steroidal, reversible small molecule inhibitor demonstrating…”
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Phase I Trial of Weekly Paclitaxel and BMS-214662 in Patients with Advanced Solid Tumors by BAILEY, Howard H, ALBERTI, Dona B, THOMAS, James P, MULKERIN, Daniel L, BINGER, Kimberly A, GOTTARDIS, Marco M, MARTELL, Robert E, WILDING, George

“…Purpose: To assess the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacodynamics, and antitumor activity of continuous weekly-administered…”
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Differential Mechanisms of Acquired Resistance to Insulin-like Growth Factor-I Receptor Antibody Therapy or to a Small-Molecule Inhibitor, BMS-754807, in a Human Rhabdomyosarcoma Model by FEI HUANG, HURLBURT, Warren, GREER, Ann, REEVES, Karen A, HILLERMAN, Stephen, HAN CHANG, FARGNOLI, Joseph, GRAF FINCKENSTEIN, Friedrich, GOTTARDIS, Marco M, CARBONI, Joan M

“…Agents targeting insulin-like growth factor-I receptor (IGF-IR), including antibodies and small-molecule inhibitors, are currently in clinical development for…”
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Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer by Branch, Jonathan R, Bush, Tammy L, Pande, Vineet, Connolly, Peter J, Zhang, Zhuming, Hickson, Ian, Ondrus, Janine, Jaensch, Steffen, Bischoff, James R, Habineza, Georges, Van Hecke, Geert, Meerpoel, Lieven, Packman, Kathryn, Parrett, Christopher J, Chong, Yolanda T, Gottardis, Marco M, Bignan, Gilles

“…Numerous mechanisms of resistance arise in response to treatment with second-generation androgen receptor (AR) pathway inhibitors in metastatic…”
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High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy by LITZENBURGER, Beate C, CREIGHTON, Chad J, LEWIS, Michael T, RIMAWI, Mothaffar F, LEE, Adrian V, TSIMELZON, Anna, CHAN, Bonita T, HILSENBECK, Susan G, TAO WANG, CARBONI, Joan M, GOTTARDIS, Marco M, FEI HUANG, CHANG, Jenny C

“…We previously reported an insulin-like growth factor (IGF) gene expression signature, based on genes induced or repressed by IGF-I, which correlated with poor…”
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